An update on the role of ferroptosis in ischemic stroke: from molecular pathways to Neuroprotection DOI

A Gowtham,

Chandan Chauhan,

Vikrant Rahi

et al.

Expert Opinion on Therapeutic Targets, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 27

Published: Dec. 23, 2024

Introduction Ischemic stroke (IS), a major cause of mortality and disability worldwide, remains significant healthcare challenge due to limited therapeutic options. Ferroptosis, distinct iron-dependent form regulated cell death characterized by lipid peroxidation oxidative stress, has emerged as crucial mechanism in IS pathophysiology. This review explores the role ferroptosis its potential for driving innovative strategies.

Language: Английский

Exploring the Nexus: How Ferroptosis, Microglia, and Neuroinflammation Converge in Ischemic Stroke Pathogenesis DOI Creative Commons

Zhiyan Liu,

Xueyang Shen,

Mingming Li

et al.

Molecular Neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: March 10, 2025

Language: Английский

Citations

0
SIRT5-mediated BCAT1 desuccinylation and stabilization leads to ferroptosis insensitivity and promotes cell proliferation in glioma DOI Creative Commons
Tao Wang,

Xin-Hao Han,

Junjun Chen

et al.

Cell Death and Disease, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 7, 2025

Language: Английский

Citations

0
Role of sirtuins in cerebral ischemia-reperfusion injury: Mechanisms and therapeutic potential DOI Creative Commons
Zheng Li, Jihong Xing

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 310, P. 143591 - 143591

Published: April 27, 2025

The high incidence and mortality rate of cardiac arrest (CA) establishes it as a critical clinical challenge in emergency medicine globally. Despite continuous advances advanced life support (ALS) technology, the prognosis for patients experiencing remains poor, with cerebral ischemia reperfusion injury (CIRI) being significant determinant adverse neurological outcomes increased mortality. Sirtuins (SIRTs) are class highly evolutionarily conserved NAD+-dependent histone deacylenzymes capable regulating expression various cytoprotective genes to play neuroprotective role CIRI. SIRTs mainly regulate levels downstream proteins such PGC 1-α, Nrf 2, NLRP 3, FoxOs, PINK 1 inhibit inflammatory response, attenuate oxidative stress, improve mitochondrial dysfunction, promote angiogenesis, apoptosis while reducing Natural active ingredients widely used protein level body because their multi-components, multi-pathway, multi-target, minimal toxic side effects. However, these naturally still face many challenges related drug targeting, pharmacokinetic properties, delivery. emergence vigorous development new delivery systems, nanoparticles, micromilk, exosomes, provide strong solving above problems. In context rapid molecular biology non-coding RNA (NcRNA), represented by miRNA LncRNA, offers great potential achieving gene-level precision medicine. multidisciplinary integration, combining biotechnology, omics technologies, artificial intelligence, material science will strongly deepening basic research expand application. This review describes major signaling pathways targeting mitigate CIRI, well current status Chinese Western medical means intervention SIRTs. Meanwhile, possible solutions application targeted drugs summarized. industrial crossover, direction future is discussed valuable reference researchers clinicians diagnosis treatment effects

Language: Английский

Citations

0
Potential therapeutic targets for ischemic stroke in pre-clinical studies: Epigenetic-modifying enzymes DNMT/TET and HAT/HDAC DOI Creative Commons

Yurou Guo,

Jing Li,

Xiaodan Liu

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Ischemic stroke (IS) remains a leading cause of mortality and disability worldwide, driven by genetic predispositions environmental interactions, with epigenetics playing pivotal role in mediating these processes. Specific modifying enzymes that regulate epigenetic changes have emerged as promising targets for IS treatment. DNA methyltransferases (DNMTs), ten-eleven translocation (TET) dioxygenases, histone acetyltransferases (HATs), deacetylases (HDACs) are central to regulation. These maintain dynamic balance between methylation/demethylation acetylation/deacetylation, which critically influences gene expression neuronal survival IS. This review is based on both vivo vitro experimental studies, exploring the roles DNMT/TET HAT/HDAC IS, evaluating their potential therapeutic targets, discussing use natural compounds modulators develop novel treatment strategies.

Language: Английский

Citations

0
Recent advances in potential therapeutic targets of ferroptosis‑associated pathways for the treatment of stroke (Review) DOI
Hao Dong, Yaping Ma,

Mei-Mei Cui

et al.

Molecular Medicine Reports, Journal Year: 2024, Volume and Issue: 30(1)

Published: May 22, 2024

Stroke is a severe neurological disease that associated with high rates of morbidity and mortality, the underlying pathological processes are complex. Ferroptosis fulfills significant role in progression treatment stroke. It well established ferroptosis type programmed cell death distinct from other forms or types death. The process involves multiple signaling pathways regulatory mechanisms interact inherent to stroke development. Inducers inhibitors have been shown exert onset this process. Furthermore, it has interfering affects occurrence stroke, indicating targeting may offer promising therapeutic approach for treating patients Hence, present review aimed summarize latest progress made terms using interventions as targets cases provides an overview relevant molecular investigated recent years, highlighting roles inducers Additionally, intervention potential various Traditional Chinese Medicine also summarized. In conclusion, comprehensive afforded by ferroptosis‑associated offering new insights into how be exploited

Language: Английский

Citations

2
Methane saline suppresses ferroptosis via the Nrf2/HO-1 signaling pathway to ameliorate intestinal ischemia–reperfusion injury DOI Creative Commons
Qingrui Fan, Hulin Chang,

Lifei Tian

et al.

Redox Report, Journal Year: 2024, Volume and Issue: 29(1)

Published: July 18, 2024

Objectives Intestinal ischemia-reperfusion (I/R) injury is a multifactorial and complex clinical pathophysiological process. Current research indicates that the pathogenesis of intestinal I/R involves various mechanisms, including ferroptosis. Methane saline (MS) has been demonstrated to primarily exert anti-inflammatory antioxidant effects in injury. In this study, we mainly investigated effect MS on ferroptosis determined its potential mechanism.

Language: Английский

Citations

2
SIRT5 safeguards against T-2 toxin induced liver injury by repressing iron accumulation, oxidative stress, and the activation of NLRP3 inflammasome DOI

Jing Huang,

Y. Wang,

Han Hu

et al.

Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 492, P. 117084 - 117084

Published: Sept. 4, 2024

Language: Английский

Citations

2
Nuclear factor erythroid 2-related factor-mediated signaling alleviates ferroptosis during cerebral ischemia-reperfusion injury DOI Open Access
Zheng Li, Jihong Xing

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 180, P. 117513 - 117513

Published: Sept. 27, 2024

Language: Английский

Citations

2
Ferroptosis: a new perspective on the pathogenesis of radiation-induced cataracts DOI Creative Commons

Yufu Tang,

Hongying Liang,

Lixia Su

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Aug. 16, 2024

Ionizing radiation is a significant risk factor for cataracts, but the pathogenesis of radiation-induced cataracts remains incompletely understood. Ferroptosis, an iron-dependent form programmed cell death discovered in recent years, has gained increasing attention its role various diseases. This article systematically reviews research progress on ionizing radiation, ferroptosis, age-related and cataracts. It proposes “ferroptosis hypothesis” Through ionization oxidative stress effects, leads to elevated free iron levels exacerbated lipid peroxidation lens cells, activating ferroptosis pathway resulting opacity. The involvement development suggests that it may also be important pathogenic mechanism Targeting novel strategy preventing treating Furthermore, developing new ferroptosis-specific inhibitors with improved targeting pharmacokinetic properties essential direction study provides insights into management potentially transforming from “inevitable” “preventable treatable.”

Language: Английский

Citations

1
Cerebroprotective action of butylphthalide in acute ischemic stroke: Potential role of Nrf2/HO-1 signaling pathway DOI Creative Commons

Rakesh B. Patel,

Anil K. Chauhan

Neurotherapeutics, Journal Year: 2024, Volume and Issue: 21(6), P. e00461 - e00461

Published: Oct. 1, 2024

Language: Английский

Citations

1