Role of Glutathione in Parkinson's Disease Pathophysiology and Therapeutic Potential of Polyphenols DOI
Chengu Niu, Miaoxian Dong,

Yingcai Niu

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

ABSTRACT Oxidative stress is recognized to have a central role in the initiation and progression of Parkinson's disease (PD). Within brain, neurons are particularly sensitive oxidation due part their weak intrinsic antioxidant defense. Theoretically, mostly depend on neighboring astrocytes provide protection by supplying cysteine‐containing products for glutathione (GSH) synthesis. Astrocytes possess several amino acid transport systems GSH its precursors. Indeed, most abundant nervous system. The depletion and/or alterations metabolism brain contribute pathogenesis PD. Noteworthy, polyphenols potent activity can augment redox Numerous vitro vivo studies indicated that exhibit neuroprotective effects Epidemiological found an association between consumption dietary lower PD risk. In this review, we summarize current knowledge biosynthesis with emphasis contribution therapeutic potential particular, focus increase levels against Furthermore, some challenges future perspectives polyphenol‐based therapies also discussed.

Language: Английский

Polysaccharides with antioxidant activity: Extraction, beneficial roles, biological mechanisms, structure-function relationships, and future perspectives: A review DOI
Xiao‐fei Liu, Liufang Huang,

Xuewu Zhang

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 300, P. 140221 - 140221

Published: Jan. 22, 2025

Language: Английский

Citations

1
Prolactin protects hippocampal neurons against H2O2-induced neurotoxicity by suppressing BAX and NOX4 via the NF-κB signaling pathway DOI Creative Commons
Fernando Macías,

Miriam Ulloa,

Carmen Clapp

et al.

PLoS ONE, Journal Year: 2024, Volume and Issue: 19(11), P. e0313328 - e0313328

Published: Nov. 5, 2024

Reactive oxygen species (ROS) are physiological byproducts of neuronal metabolism. However, an imbalance between ROS generation and antioxidant capacity, often driven by dysregulated pro-oxidant enzymes like nicotinamide adenine dinucleotide phosphate oxidases (NOX), can result in deleterious oxidative stress. This stress is a critical factor the pathogenesis neurodegenerative diseases. While interventions with broad-spectrum antioxidants have demonstrated limited efficacy, modulation endogenous mechanisms presents promising therapeutic avenue. Here, we investigated potential neuroprotective hormone prolactin to mitigate subsequent cell death. Prolactin protected primary mouse hippocampal neurons from hydrogen peroxide (H 2 O )-induced damage. reduced levels, lipid peroxidation, apoptosis, its effects were occluded specific receptor antagonist (G129R-hPRL). Mechanistically, suppressed H -induced mRNA upregulation pro-oxidative Nox4 pro-apoptotic Bax . Moreover, induced nuclear kappa B (NF-κB) translocation, inhibition NF-κB signaling pathway abolished transcriptional prolactin, indicating central role prolactin-mediated protection. Our findings indicate that exerts potent modulating expression , thereby reducing apoptosis. study underscores attenuating suggests possible treatment

Language: Английский

Citations

1
Traumatic brain injury and prolactin DOI
Ayşa Hacıoğlu, Fatih Tanrıverdi

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Language: Английский

Citations

0
Role of Glutathione in Parkinson's Disease Pathophysiology and Therapeutic Potential of Polyphenols DOI
Chengu Niu, Miaoxian Dong,

Yingcai Niu

et al.

Phytotherapy Research, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 17, 2024

ABSTRACT Oxidative stress is recognized to have a central role in the initiation and progression of Parkinson's disease (PD). Within brain, neurons are particularly sensitive oxidation due part their weak intrinsic antioxidant defense. Theoretically, mostly depend on neighboring astrocytes provide protection by supplying cysteine‐containing products for glutathione (GSH) synthesis. Astrocytes possess several amino acid transport systems GSH its precursors. Indeed, most abundant nervous system. The depletion and/or alterations metabolism brain contribute pathogenesis PD. Noteworthy, polyphenols potent activity can augment redox Numerous vitro vivo studies indicated that exhibit neuroprotective effects Epidemiological found an association between consumption dietary lower PD risk. In this review, we summarize current knowledge biosynthesis with emphasis contribution therapeutic potential particular, focus increase levels against Furthermore, some challenges future perspectives polyphenol‐based therapies also discussed.

Language: Английский

Citations

0