International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(20), P. 10909 - 10909
Published: Oct. 10, 2024
Multiple
sclerosis
(MS)
is
an
immune-mediated
disease
characterized
by
inflammation,
demyelination,
and
neurodegeneration
within
the
central
nervous
system.
Brain
plasticity,
brain’s
ability
to
adapt
its
structure
function,
plays
a
crucial
role
in
mitigating
MS’s
impact.
This
paper
explores
potential
benefits
of
lifestyle
changes
nutraceuticals
on
brain
plasticity
MS
population.
Lifestyle
modifications,
including
physical
activity
dietary
adjustments,
can
enhance
upregulating
neurotrophic
factors,
promoting
synaptogenesis,
reducing
oxidative
stress.
Nutraceuticals,
such
as
vitamin
D,
omega-3
fatty
acids,
antioxidants
like
alpha
lipoic
acid,
have
shown
promise
supporting
health
through
anti-inflammatory
neuroprotective
mechanisms.
Regular
has
been
linked
increased
levels
brain-derived
factor
improved
cognitive
function.
Dietary
interventions,
caloric
restriction
intake
polyphenols,
also
positively
influence
plasticity.
Integrating
these
into
management
provide
complementary
approach
traditional
therapies,
potentially
improving
neurological
outcomes
enhancing
quality
life
for
Journal of Clinical Medicine,
Journal Year:
2025,
Volume and Issue:
14(2), P. 386 - 386
Published: Jan. 9, 2025
The
blood-brain
barrier
(BBB)
is
a
crucial
structure
that
maintains
brain
homeostasis
by
regulating
the
entry
of
molecules
and
cells
from
bloodstream
into
central
nervous
system
(CNS).
Neurodegenerative
diseases
such
as
Alzheimer's
Parkinson's
disease,
well
ischemic
stroke,
compromise
integrity
BBB.
This
leads
to
increased
permeability
infiltration
harmful
substances,
thereby
accelerating
neurodegeneration.
In
this
review,
we
explore
mechanisms
underlying
BBB
disruption,
including
oxidative
stress,
neuroinflammation,
vascular
dysfunction,
loss
tight
junction
integrity,
in
patients
with
neurodegenerative
diseases.
We
discuss
how
breakdown
contributes
neurotoxicity,
abnormal
accumulation
pathological
proteins,
all
which
exacerbate
neuronal
damage
facilitate
disease
progression.
Furthermore,
potential
therapeutic
strategies
aimed
at
preserving
or
restoring
function,
anti-inflammatory
treatments,
antioxidant
therapies,
approaches
enhance
integrity.
Given
role
neurodegeneration,
maintaining
its
represents
promising
approach
slow
prevent
progression
Plants,
Journal Year:
2024,
Volume and Issue:
13(13), P. 1815 - 1815
Published: July 1, 2024
Rumex
vesicarius
L.
Polygonaceae
is
a
wildly
grown
plant
in
Egypt,
North
Africa,
and
Asia
with
wide
traditional
uses.
Several
studies
reported
its
biological
activities
richness
phytochemicals.
This
research
addresses
comprehensive
metabolic
profiling
of
the
flowers,
leaves,
stems,
roots
via
RP-HPLC-QTOF-MS
MS/MS
chemometrics.
A
total
60
metabolites
were
observed
grouped
into
phenolic
acids,
flavonoids,
phenols,
terpenes,
amino
fatty
organic
sugars.
Principal
component
analysis
hierarchal
cluster
showed
segregation
different
parts.
Moreover,
antioxidant
capacity
was
determined
several
methods
agreed
previous
results.
Additionally,
an
silico
approach
molecular
docking
predominant
bioactive
employed
against
two
targets,
NADPH
oxidase
human
peroxiredoxin
5
enzyme
(PDB
ID:
2CDU
1HD2)
receptors,
alongside
ADME
predictions.
The
modelling
revealed
that
most
approached
molecules
specifically
binding
tested
enzymes,
achieving
high
affinities.
results
confirmed
R.
stems
are
rich
sources
components.
To
our
knowledge,
this
first
giving
prospect
relevance
development
new
naturally
based
antioxidants.
Antioxidants,
Journal Year:
2025,
Volume and Issue:
14(3), P. 272 - 272
Published: Feb. 26, 2025
Currently,
nutraceuticals
and
functional
food/cosmeceutical
sectors
are
seeking
natural
molecules
to
develop
various
types
of
phytopharmaceutical
products.
Flavonoids
have
been
reported
in
antioxidant
many
medical/pharmacological
activities.
Monochoria
angustifolia
or
Siam
violet
pearl
medicinal
plant
is
the
newest
species
genus
C.
Presl,
which
long
consumed
as
food
herbal
medicines.
Though
previous
work
showed
that
apigenin-7-O-glucoside
most
abundant
phytochemical
found
this
plant,
report
on
anti-aging
activity
still
lacking
needs
be
filled
in.
The
objective
explore
capacities
using
both
silico
vitro
assessments.
In
addition,
pharmacokinetic
properties
were
predicted.
Interestingly,
results
from
analysis
a
similar
trend
potential
agent
against
three
enzymes.
properties,
such
adsorption,
distribution,
metabolism,
excretion
toxicity
(ADMET),
compound
also
provided
work.
current
study
first
Thai
plant.
However,
safety
efficacy
future
developed
products
clinical
should
determined
future.
Pharmacology Research & Perspectives,
Journal Year:
2025,
Volume and Issue:
13(3)
Published: April 25, 2025
ABSTRACT
Parkinson's
disease
(PD)
is
the
most
prevalent
neurodegenerative
disease.
Previously,
it
was
believed
that
aberrant
iron
metabolism,
leading
to
ferroptosis
due
glutathione
(GSH)
depletion,
excessive
Ca
2+
influx,
mitochondrial
(mROS),
and
cytosolic
(cROS)
free
reactive
oxygen
species
in
brain,
a
contributing
factor
PD.
ADP‐ribose
(ADPR),
mROS,
cROS
activate
TRPM2
cation
channel.
It
yet
unclear
how
contributes
development
of
neuronal
damage
induced
by
rise
Our
aim
this
study
examine
function
protective
effect
GSH
dopaminergic
human
SH‐SY5Y
cells
had
been
exposed
1‐methyl
4‐phenylpyridinium
(MPP)
produce
parkinsonism.
The
were
divided
into
six
groups:
control,
MPP,
MPP
+
erastin,
erastin
ferrostatin‐1,
(GSH),
blocker
(ACA).
In
groups,
concentrations
,
ADPR‐induced
current
density,
membrane
dysfunction,
cROS,
lipid
peroxidation,
Zn
Fe
increased,
although
peroxidase,
GSH,
cell
viability,
number
decreased.
changes
higher
group
than
only.
However,
their
modulated
ACA
groups.
conclusion,
increase
death
parkinsonism
(MPP)‐induced
attributed
activation.
By
regulating
oxidant/antioxidant
balance,
regulates
channel
activity
lowers
ferroptosis.
Frontiers in Nutrition,
Journal Year:
2025,
Volume and Issue:
12
Published: May 16, 2025
Objectives
Dietary
flavonoids,
known
for
their
antioxidant
and
anti-inflammatory
properties,
may
play
a
role
in
frailty
prevention,
but
comprehensive
population-based
studies
are
lacking.
This
study
aimed
to
examine
the
associations
between
dietary
flavonoid
intakes
prevalence
of
nationally
representative
sample
U.S.
adults,
identify
predominant
subclasses
contributing
these
associations.
Methods
Cross-sectional
data
from
12,152
adults
aged
≥20
years
participating
National
Health
Nutrition
Examination
Survey
(NHANES)
2007–2010
2017–2018
were
analyzed.
intake
was
assessed
using
two
24-h
recalls.
Frailty
defined
49-item
index.
Weighted
multivariate
logistic
regression
models
restricted
cubic
spline
analyses
employed
investigate
relationships
prevalence.
quantile
sum
(WQS)
g-computation
(qgcomp)
used
assess
mixed
effects
subclasses.
Results
Higher
total
flavonoids
(OR:0.79,
95%
CI:0.65–0.95),
anthocyanidins
(OR:0.71,
CI:0.58–0.88),
flavanones
(OR:0.74,
CI:0.59–0.92),
flavones
(OR:0.76,
CI:0.59–0.97),
flavonols
(OR:0.67,
CI:0.56–0.81)
significantly
associated
with
lower
after
adjusting
confounders.
Non-linear
inverse
observed
flavonols.
The
WQS
model
revealed
that
mixture
inversely
odds
(OR:
0.58,
CI:
0.48–0.71,
p
<
0.001),
flavones,
flavonols,
as
top
contributors.
qgcomp
confirmed
findings
highlighted
potential
opposing
among
Conclusion
analysis
provides
evidence
higher
intakes,
particularly
anthocyanidins,
adults.
These
suggest
flavonoid-rich
diets
be
promising
strategy
warranting
further
investigation
through
prospective
cohort
randomized
controlled
trials.
Multiple
sclerosis
(MS)
is
an
immune-mediated
disease
characterized
by
inflammation,
demyelination,
and
neurodegeneration
within
the
central
nervous
system.
Brain
plasticity,
brain's
ability
to
adapt
its
structure
function,
plays
a
crucial
role
in
mitigating
MS's
impact.
This
paper
explores
potential
benefits
of
lifestyle
changes
nutraceuticals
on
brain
plasticity
MS
patients.
Lifestyle
modifications,
including
physical
activity
dietary
adjustments,
can
enhance
upregulating
neurotrophic
factors,
promoting
synaptogenesis,
reducing
oxidative
stress.
Nutraceuticals,
such
as
vitamin
D,
omega-3
fatty
acids,
antioxidants
like
alpha-lipoic
acid,
have
shown
promise
supporting
health
through
anti-inflammatory
neuroprotective
mechanisms.
Regular
has
been
linked
increased
levels
brain-derived
factor
(BDNF)
improved
cognitive
function.
Dietary
interventions,
caloric
restriction
intake
polyphenols,
also
positively
influence
plasticity.
Integrating
these
into
management
could
provide
complementary
approach
traditional
therapies,
potentially
improving
neurological
outcomes
enhancing
quality
life
for
