A Levodopa-Encapsulated Poly-ε-Caprolactone Nanocomposite Improves the Motor Symptoms and Neurochemical Changes in a Rotenone-Induced Mouse Model of Parkinson’s Disease DOI Creative Commons
Ramesha Hanumanthappa,

Geetha B. Heggannavar,

Aishwarya Banakar

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(19), P. 19682 - 19696

Published: May 6, 2025

Parkinson's disease (PD) is the most common neurodegenerative disorder; in this condition, patients lose dopamine (DA), which leads to abnormal motor functions. Levodopa (LD) effective drug used for treatment of PD; however, LD shows poor plasma bioavailability and limited brain uptake induces peripheral side effects. Due its availability short half-life, prolonged must be repeated with a dosing schedule, long-term effects, including dyskinesia, stomatitis, anxiety, depression. An LD-encapsulated polymer nanocomposite has been reported overcome these problems. The present study aims improve efficiency an strategy PD. Herein, we report newly synthesized poly-ε-caprolactone (PCL) (LD-PCL-PVA NC), chemical physical properties were analyzed. LD-PCL-PVA NC exhibits no toxicity on SH-SY5Y cell line improved mouse plasma. Furthermore, found that showed significant improvement symptoms rotenone (RT)-induced PD model compared treatment. In addition, significantly increased DA homovanillic acid restored total glutathione level malonaldehyde catalase activity brain. histopathology studies reveal did not exhibit treated mice. suggested can promising

Language: Английский

JAK/STAT3 signaling promotes pain and depression-like behaviors in rats with bone cancer pain by regulating Th17 cell differentiation DOI Creative Commons

Shuyan Wu,

Jundan Jiang, Danfeng Wang

et al.

Brain Research Bulletin, Journal Year: 2025, Volume and Issue: unknown, P. 111218 - 111218

Published: Jan. 1, 2025

Language: Английский

Citations

0
Targeting the sigma-1 receptor with pridopidine induces functional neurorestoration in spinal cord ischemia-reperfusion injury DOI Creative Commons
Eman Sweed, Suzan A Khodir, Shaimaa M. Motawea

et al.

Naunyn-Schmiedeberg s Archives of Pharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Language: Английский

Citations

0
Uncovering the therapeutic potentials of marine-derived natural compounds with small amounts for neurological disorders DOI

Yirui Hong,

Xinyu Zhang,

Wenni Rong

et al.

Gene, Journal Year: 2025, Volume and Issue: unknown, P. 149465 - 149465

Published: April 1, 2025

Language: Английский

Citations

0
A Levodopa-Encapsulated Poly-ε-Caprolactone Nanocomposite Improves the Motor Symptoms and Neurochemical Changes in a Rotenone-Induced Mouse Model of Parkinson’s Disease DOI Creative Commons
Ramesha Hanumanthappa,

Geetha B. Heggannavar,

Aishwarya Banakar

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(19), P. 19682 - 19696

Published: May 6, 2025

Parkinson's disease (PD) is the most common neurodegenerative disorder; in this condition, patients lose dopamine (DA), which leads to abnormal motor functions. Levodopa (LD) effective drug used for treatment of PD; however, LD shows poor plasma bioavailability and limited brain uptake induces peripheral side effects. Due its availability short half-life, prolonged must be repeated with a dosing schedule, long-term effects, including dyskinesia, stomatitis, anxiety, depression. An LD-encapsulated polymer nanocomposite has been reported overcome these problems. The present study aims improve efficiency an strategy PD. Herein, we report newly synthesized poly-ε-caprolactone (PCL) (LD-PCL-PVA NC), chemical physical properties were analyzed. LD-PCL-PVA NC exhibits no toxicity on SH-SY5Y cell line improved mouse plasma. Furthermore, found that showed significant improvement symptoms rotenone (RT)-induced PD model compared treatment. In addition, significantly increased DA homovanillic acid restored total glutathione level malonaldehyde catalase activity brain. histopathology studies reveal did not exhibit treated mice. suggested can promising

Language: Английский

Citations

0