Protective effects of harpagoside on mitochondrial functions in rotenone‑induced cell models of Parkinson's disease

Biomedical Reports, Journal Year: 2025, Volume and Issue: 22(4)

Published: Feb. 11, 2025

Parkinson's disease (PD) is the second most common neurodegenerative after Alzheimer's disease. Currently, no radical treatment available for this Harpagoside a proposed neuroprotective iridoid active ingredient that can be derived from Scrophulariae buergeriana, Scrophularia striata and Harpagophytum procumbens. The present study aimed to investigate effects of harpagoside on mitochondrial functions in rotenone-induced cell models (PD). Neuro-2A (N2A) cells were treated with rotenone establish vitro PD. Cell viability survival measured using Counting Kit-8 assay. Biochemical assays spectrophotometry used measure complex I activity, swelling caspase 3 activity. rate was first found significantly decreased by (20 nmol/l) treatment. However, intervention (10 µmol/l) increase N2A differentiated 1 mmol/l dibutyryl-cAMP. At ≥0.1 µmol/l concentration, alleviated swelling, whereas at it counteracted inhibitory 10 inhibited activation. These results suggest has potential protect against injury

Language: Английский

Betanin: A potent antioxidant molecule and its therapeutic implications

International Immunopharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 114257 - 114257

Published: Feb. 1, 2025

Language: Английский