Efficacy of Sodium Channel-Selective Analgesics in Postoperative, Neuralgia, and Neuropathy-Related Pain Management: A Systematic Review and Literature Review

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2460 - 2460

Published: March 10, 2025

Postoperative pain is a prevalent problem, often lasting from days to years. To minimize opioid use and associated risks of dependency, Enhanced Recovery After Surgery (ERAS) protocols increasingly incorporate multimodal analgesics. Sodium channel-selective blockers are promising non-opioid alternative, yet their application in postoperative remains underexplored. This systematic review evaluates efficacy managing postoperative, neuropathic, neuralgia-related pain. A was conducted using controlled keywords across multiple databases identify studies on sodium published up 2024. Eligible included clinical trials, observational studies, case series, reports involving patients aged 18 or older. Data were extracted therapeutic outcomes, dosages, complications, comparisons with other Five met the inclusion criteria, 804 patients, 81.58% whom women. One study addressed pain, while remaining five focused neuropathy- All reported significant reduction at least one treatment group compared placebo. In blocker significantly reduced scores without requiring analgesia. Across all only two needed concomitant therapy, discontinued due adverse effects. Dosages varied, no severe complications. Comparative analyses showed that as effective, if not superior, traditional medications reducing intensity. demonstrate potential management minimal reliance. While effective for neuropathic further essential validate role acute settings refine analgesia regimens.

Language: Английский

Significance of NMDA receptor-targeting compounds in neuropsychological disorders: An In-depth Review

European Journal of Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 177690 - 177690

Published: April 1, 2025

Language: Английский