Foam 3D Printing of Thermoplastics: A Symbiosis of Additive Manufacturing and Foaming Technology DOI
Mohammadreza Nofar, Julia Utz, Nico Geis

et al.

Advanced Science, Journal Year: 2022, Volume and Issue: 9(11)

Published: Feb. 20, 2022

Due to their light-weight and cost-effectiveness, cellular thermoplastic foams are considered as important engineering materials. On the other hand, additive manufacturing or 3D printing is one of emerging fastest growing technologies due its advantages such design freedom tool-less production. Nowadays, polymer compounds mostly limited solid parts. In this context, a merged foaming technology can introduce great alternative for currently used foam injection molding. This perspective review article tackles attempts taken toward initiating novel simultaneously print thermoplastics. After explaining basics manufacturing, classifies different that have been made generating foamed printed structures while highlighting challenges. These clustered into 1) architected porous structures, 2) syntactic foaming, 3) post-foaming parts, eventually 4) blowing agents saturated filaments. Among these, latest approach most practical route although it has not thoroughly studied yet. A filament free be introduced potential strategy unlock difficulties produce also proposed.

Language: Английский

3D printing: Principles and pharmaceutical applications of selective laser sintering DOI
Atheer Awad, Fabrizio Fina, Álvaro Goyanes

et al.

International Journal of Pharmaceutics, Journal Year: 2020, Volume and Issue: 586, P. 119594 - 119594

Published: July 2, 2020

Language: Английский

Citations

302

Polymers for Extrusion-Based 3D Printing of Pharmaceuticals: A Holistic Materials–Process Perspective DOI Creative Commons
Mohammad Azad,

Deborah Olawuni,

Georgia Kimbell

et al.

Pharmaceutics, Journal Year: 2020, Volume and Issue: 12(2), P. 124 - 124

Published: Feb. 3, 2020

Three dimensional (3D) printing as an advanced manufacturing technology is progressing to be established in the pharmaceutical industry overcome traditional regime of 'one size fits for all'. Using 3D printing, it possible design and develop complex dosage forms that can suitable tuning drug release. Polymers are key materials necessary printing. Among all processes, extrusion-based (both fused deposition modeling (FDM) pressure-assisted microsyringe (PAM)) well researched manufacturing. It important understand which polymers pharmaceuticals how their properties, behavior polymer–active ingredient (API) combinations, impact process. Especially, understanding rheology polymer API–polymer mixtures successful or printed structures. This review has summarized a holistic materials–process perspective on The main focus herein will both FDM PAM processes. elaborates discussion comparison with direct compression process, necessity rheology, characterization techniques required structure, drug, excipients. current technological challenges, regulatory aspects, direction toward moving, especially personalized multi-drug also briefly discussed.

Language: Английский

Citations

293

3D printing technology; methods, biomedical applications, future opportunities and trends DOI Creative Commons
Yahya Bozkurt, Elif Karayel

Journal of Materials Research and Technology, Journal Year: 2021, Volume and Issue: 14, P. 1430 - 1450

Published: July 16, 2021

3D printer technology is one of the innovations brought by industrial age. It has been in our lives for many years. rapidly developing and used sectors like aviation defence industry. This miracle manufacturing method frequently preferred medical applications recent In this study, introduced, various printing are mentioned use biomedical referred. The surgery, pharmaceutical industry, disease modelling, development customized implants prostheses, organ printing, vet medicine tissue engineering have explained new compared with traditional methods that field. addition, study includes future opportunities expected to become widespread developed future.

Language: Английский

Citations

267

Antioxidant PLA Composites Containing Lignin for 3D Printing Applications: A Potential Material for Healthcare Applications DOI Creative Commons
Juan Domínguez‐Robles,

Niamh K. Martin,

Mun Leon Fong

et al.

Pharmaceutics, Journal Year: 2019, Volume and Issue: 11(4), P. 165 - 165

Published: April 4, 2019

Lignin (LIG) is a natural biopolymer with well-known antioxidant capabilities. Accordingly, in the present work, method to combine LIG poly(lactic acid) (PLA) for fused filament fabrication applications (FFF) proposed. For this purpose, PLA pellets were successfully coated powder and biocompatible oil (castor oil). The resulting placed into an extruder at 200 °C. filaments contained loadings ranging from 0% 3% (w/w). obtained used FFF applications. content affected mechanical surface properties of overall material. inclusion yielded materials lower resistance fracture higher wettabilities. Moreover, 3D printed showed By using 2,2-diphenyl-1-picrylhydrazyl (DPPH) method, capable reducing concentration compound up ca. 80% 5 h. This radical scavenging activity could be potentially beneficial healthcare applications, especially wound care. PLA/LIG design meshes different designs dressing purposes. A healing model compound, curcumin (CUR), was applied mesh its diffusion studied. It observed that dimensions permeation rate CUR. modified according patient's needs.

Language: Английский

Citations

247

An overview of modern metal additive manufacturing technology DOI Creative Commons
Mark Armstrong, Hamid Mehrabi, Nida Naveed

et al.

Journal of Manufacturing Processes, Journal Year: 2022, Volume and Issue: 84, P. 1001 - 1029

Published: Nov. 4, 2022

There has been significant development in metal additive manufacturing (MAM) technology over the past few decades, and considerable progress made understanding how various processes their parameters influence properties of printed metallic parts. Despite this, knowledge concerning its characteristics dispersed across a variety publications sources, making it difficult to gain comprehensive entire field, especially for businesses interested (AM). In order bridge this gap, periodic reviews encompassing state-of-the-art as whole are necessary. Therefore, article provides overview essential features MAM techniques based on most recent scientific knowledge. It explores emerging research four technologies, including material extrusion (ME), binder jetting (BJ), powder bed fusion (PBF), directed energy deposition (DED). As well providing an outline fundamental process characteristics, ongoing efforts optimize them current challenges, also highlights gaps future needs. A feature review is provision substantial documentation regarding mechanical materials processed by commercial systems, novel hybrid (HAM) machines. This accompanied investigation into works done characterize environmental impact along with conceptual framework improving efficiency (EE) process. result reporting both several sustainability one integrated article, anticipated that information will serve valuable resource academic communities better appreciate understand what differentiates from traditional (TM) processes, thus facilitating advancement adoption.

Language: Английский

Citations

224

A review of fabrication polymer scaffolds for biomedical applications using additive manufacturing techniques DOI
Patrycja Szymczyk‐Ziółkowska, Magdalena B. Łabowska, Jerzy Detyna

et al.

Journal of Applied Biomedicine, Journal Year: 2020, Volume and Issue: 40(2), P. 624 - 638

Published: Feb. 20, 2020

Language: Английский

Citations

214

Advances in powder bed fusion 3D printing in drug delivery and healthcare DOI
Atheer Awad, Fabrizio Fina, Álvaro Goyanes

et al.

Advanced Drug Delivery Reviews, Journal Year: 2021, Volume and Issue: 174, P. 406 - 424

Published: May 2, 2021

Language: Английский

Citations

182

The Digital Pharmacies Era: How 3D Printing Technology Using Fused Deposition Modeling Can Become a Reality DOI Creative Commons

Maisa R. P. Araújo,

Lívia Cristina Lira de Sá Barreto, Taís Gratieri

et al.

Pharmaceutics, Journal Year: 2019, Volume and Issue: 11(3), P. 128 - 128

Published: March 19, 2019

The pharmaceutical industry is set to join the fourth industrial revolution with 3D printing of medicines. application printers in compounding pharmacies will turn them into digital pharmacies, wrapping up telemedicine care cycle and definitively modifying pharmacotherapeutic treatment patients. Fused deposition modeling technology melts extruded drug-loaded filaments any dosage form; allows obtainment flexible dosages different shapes, multiple active ingredients modulated drug release kinetics—in other words, offering customized medicine. This work aimed present an update on this technology, discussing its challenges. co-participation seems be best way reality. can produce a large scale necessary quality safety guarantees; while transform personalized medicine according specific prescriptions. For occur, adaptations commercial need meet health requirements for products preparation, it make advances regulatory gaps discussions patent protection. Thus, despite conservatism sector, has potential become biggest technological leap ever seen segment, most optimistic prognostics, soon within reach.

Language: Английский

Citations

167

Trends in 3D Printing Processes for Biomedical Field: Opportunities and Challenges DOI Open Access

Alina Ghilan,

Aurica P. Chiriac, Loredana E. Niţă

et al.

Journal of Polymers and the Environment, Journal Year: 2020, Volume and Issue: 28(5), P. 1345 - 1367

Published: March 31, 2020

Language: Английский

Citations

165

Recent advances in high-strength and elastic hydrogels for 3D printing in biomedical applications DOI
Cancan Xu, Guohao Dai, Yi Hong

et al.

Acta Biomaterialia, Journal Year: 2019, Volume and Issue: 95, P. 50 - 59

Published: May 22, 2019

Language: Английский

Citations

160