AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(8)
Published: Oct. 30, 2024
Language: Английский
Drug Delivery and Translational Research, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 21, 2024
Abstract Transdermal drug delivery (TDD) using electrically assisted microneedle (MN) systems has emerged as a promising alternative to traditional administration routes. This review explores recent advancements in this technology across various therapeutic applications. Integrating iontophoresis (IP) and electroporation (EP) with MN shown significant potential improving treatment outcomes for conditions. Studies demonstrate their effectiveness enhancing vaccine DNA delivery, diabetes management, increasing efficacy dermatological The also exhibited promise delivering nonsteroidal anti-inflammatory drugs (NSAIDs), treating multiple sclerosis, advancing obesity cancer therapy. These offer improved permeation, targeted enhanced effects. While challenges remain, including safety concerns technological limitations, ongoing research focuses on optimizing these broader clinical future of technologies TDD appears promising, personalized medicine, smart monitoring systems, expanded Graphical
Language: Английский
Citations
6
Molecules, Journal Year: 2025, Volume and Issue: 30(3), P. 512 - 512
Published: Jan. 23, 2025
The rise of antibiotic-resistant Staphylococcus aureus strains, particularly MRSA, complicates the management skin and soft tissue infections. This review highlights ultrasonic methodologies as adjunctive therapies to combat S. aureus-driven infections prevent progression biofilm formation chronic wounds. Low- high-frequency ultrasound (LFU HFU) demonstrate potential in disrupting biofilms, enhancing drug delivery, promoting repair through cavitation microbubble activity. These approaches integrate frequencies with microbubbles therapeutics, such antibiotics affimers, minimize resistance improve healing. Tailoring bioeffects on structures localized delivery technologies, including microneedle patches piezoelectric systems, presents promising solutions for early intervention structure (SSSIs).
Language: Английский
Citations
0
Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(2), P. 248 - 248
Published: Feb. 13, 2025
Obesity has become a major public health threat, as it can cause various complications such diabetes, cardiovascular disease, sleep apnea, cancer, and osteoarthritis. The primary anti-obesity therapies include dietary control, physical exercise, surgical interventions, drug therapy; however, these treatments often have poor therapeutic efficacy, significant side effects, unavoidable weight rebound. As revolutionized transdermal delivery system, microneedles (MNs) been increasingly used to deliver therapeutics subcutaneous adipose tissue or targeted absorption sites, significantly enhancing anti-obese effects. Nevertheless, there is still lack of review comprehensively summarize the latest progress MN-mediated treatment obesity. This provides an overview application MN technology in obesity, focusing on promote browning white (WAT), suppress adipogenesis, improve metabolic function. In addition, this presents detailed examples integration with iontophoresis (INT) photothermal therapy (PTT) penetration into deeper dermis exert synergistic Furthermore, challenges prospects for obesity are also discussed, which helps guide design optimization MNs. Overall, insight development clinical translation
Language: Английский
Citations
0
Expert Opinion on Drug Delivery, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
Iontophoresis has been extensively studied for topical and transdermal drug delivery to stimulate the absorption of molecules that would hardly pass through outermost layer skin passively. Recent research focused on its combination with nanoparticle-based systems or microneedles expand therapeutic applications. This review explores fundamental principles iontophoresis, focusing key factors influencing transport mechanisms, provides a discussion field's current state. A comprehensive analysis articles published available online in 2024 was conducted, categorizing studies by their application areas, systems, iontophoretic conditions, experimental limitations. The findings reveal recent focus wound healing repair, advancements treating inflammation, pain, cancer. Market translation requires standardized protocols, particularly parameters preclinical models, along development cost-effective commercial devices. Additionally, while cutaneous have increasingly benefited from machine learning approaches, iontophoresis remains underexplored. With growing interest associating Internet Things, such an integration, if combined AI tools, could offer promising opportunities personalized, real-time treatments modern dermatology, systems.
Language: Английский
Citations
0
AAPS PharmSciTech, Journal Year: 2024, Volume and Issue: 25(8)
Published: Oct. 30, 2024
Language: Английский
Citations
1