Antibacterial Properties of Polyphenols: Characterization and QSAR (Quantitative Structure–Activity Relationship) Models

Frontiers in Microbiology, Journal Year: 2019, Volume and Issue: 10

Published: April 18, 2019

Besides their established antioxidant activity, many phenolic compounds may exhibit significant antibacterial activity. Here, the effect of a large dataset 35 polyphenols on growth 6 foodborne pathogenic or food-spoiling bacterial strains, three Gram-positive ones (Staphylococcus aureus, Bacillus subtilis, and Listeria monocytogenes) Gram-negative (Escherichia coli, Pseudomonas aeruginosa, Salmonella Enteritidis), have been characterized. As expected, effects were highly heterogeneous ranging from stimulation to activity depended strains. The each was expressed as relative Bacterial Load Difference (BLD) between culture with without (control) at 1 g L-1 concentration after 24 h incubation 37°C. Reliable Quantitative Structure-Activity Relationship (QSAR) models developed (regardless polyphenol class mechanism action involved) predict BLD for E. S. Enteritidis, B. unlike L. monocytogenes P. aeruginosa. generally sensitive whereas aeruginosa not. No satisfactory predicting obtained due specific quite constant behavior toward polyphenols. main descriptors involved in reliable QSAR lipophilicity electronic charge properties two bacteria (E. Enteritidis) comparable suggesting similar mechanisms toxic action. This not clearly observed (S. aureus subtilis). Interestingly, preliminary evaluation by Microbial Adhesion To Solvents (MATS) measurements surface which based physico-chemical descriptors, revealed that MATS results also similar. Moreover, strains subtilis QSARs strongly differed. These observations suggest most likely depends interactions cells surface, although should be further investigated other techniques than MATS.

Language: Английский

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Bioactivity of dietary polyphenols: The role of metabolites

Critical Reviews in Food Science and Nutrition, Journal Year: 2019, Volume and Issue: 60(4), P. 626 - 659

Published: Jan. 7, 2019

A polyphenol-rich diet protects against chronic pathologies by modulating numerous physiological processes, such as cellular redox potential, enzymatic activity, cell proliferation and signaling transduction pathways. However, polyphenols have a low oral bioavailability mainly due to an extensive biotransformation mediated phase I II reactions in enterocytes liver but also gut microbiota. Despite bioavailability, most proved significant biological effects which brought into attention the bioavailability/high bioactivity paradox. In recent years, polyphenol metabolites attracted great interest many of them showed similar or higher intrinsic comparison parent compounds. There is huge body literature reporting on functions generated metabolic microbiota-mediated biotransformation. this respect, review highlights pharmacokinetic fate major dietary (resveratrol, curcumin, quercetin, rutin, genistein, daidzein, ellagitannins, proanthocyanidins) order further address efficacy biometabolites compared molecules. The present work strongly supports contribution health benefits polyphenols, thus offering better perspective understanding role played human health.

Language: Английский

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Probiotic: conceptualization from a new approach

Current Opinion in Food Science, Journal Year: 2020, Volume and Issue: 32, P. 103 - 123

Published: April 1, 2020

Language: Английский

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Catechins and Their Therapeutic Benefits to Inflammatory Bowel Disease

Molecules, Journal Year: 2017, Volume and Issue: 22(3), P. 484 - 484

Published: March 19, 2017

Catechins are natural polyphenolic phytochemicals that exist in food and medicinal plants, such as tea, legume rubiaceae. An increasing number of studies have associated the intake catechins-rich foods with prevention treatment chronic diseases humans, inflammatory bowel disease (IBD). Some demonstrated catechins could significantly inhibit excessive oxidative stress through direct or indirect antioxidant effects promote activation antioxidative substances glutathione peroxidases (GPO) (GSH), reducing damages to colon. In addition, can also regulate infiltration proliferation immune related-cells, neutrophils, colonic epithelial cells, macrophages, T lymphocytes, helping reduce relations provide benefits IBD. Perhaps further deterioration intestinal lesions regulating cell gap junctions. Furthermore, exert their significant anti-inflammatory properties by deactivation inflammation-related stress-related signaling pathways, nuclear factor-kappa B (NF-κB), mitogen activated protein kinases (MAPKs), transcription factor (erythroid-derived 2)-like 2 (Nrf2), signal transducer activator 1/3 (STAT1/3) pathways. Finally, stabilize structure gastrointestinal micro-ecological environment via promoting beneficial bacteria balance flora, so relieve may tight junctions (TJ) epithelium. This paper elaborates currently known possible molecular mechanisms favor

Language: Английский

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Role of the small intestine, colon and microbiota in determining the metabolic fate of polyphenols

Biochemical Pharmacology, Journal Year: 2017, Volume and Issue: 139, P. 24 - 39

Published: March 18, 2017

Language: Английский

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Interaction of dietary polyphenols and gut microbiota: Microbial metabolism of polyphenols, influence on the gut microbiota, and implications on host health

Food Frontiers, Journal Year: 2020, Volume and Issue: 1(2), P. 109 - 133

Published: June 1, 2020

Abstract The human gastrointestinal tract is inhabited by a vast number of microorganisms that are called as the microbiota. Each individual harbors unique gut microbial composition, this composition evolves throughout host's lifetime and it easily affected internal or external changes. It has been shown microbiota plays crucial role in health complex community ability to interact with each other immune system, presence absence some major species can affect homeostasis. Diet be considered one pivotal factors modulating functionality, integrity, first organ exposed components diet. In review, we have focused on effects polyphenols, key compounds healthy diet several biological activities, their biotransformation microbiota, effect reciprocal interactions disease.

Language: Английский

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An in vitro batch fermentation protocol for studying the contribution of food to gut microbiota composition and functionality

Nature Protocols, Journal Year: 2021, Volume and Issue: 16(7), P. 3186 - 3209

Published: June 4, 2021

Language: Английский

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The mechanism(s) of action of antioxidants: From scavenging reactive oxygen/nitrogen species to redox signaling and the generation of bioactive secondary metabolites

Medicinal Research Reviews, Journal Year: 2019, Volume and Issue: 39(6), P. 2505 - 2533

Published: May 10, 2019

Abstract Small molecule, dietary antioxidants exert a remarkably broad range of bioactivities, and many these can be explained by the influence on redox homeostasis. Such compounds help to modulate levels harmful reactive oxygen/nitrogen species, therefore participate in regulation various signaling pathways. However, upon ingestion, usually undergo extensive metabolism that generate wide bioactive metabolites. This makes it difficult, but otherwise need, identify ones responsible for different activities antioxidants. By better understanding their ways action, use therapy improved. review provides summary role vivo metabolic changes oxidized metabolites mechanisms behind bioactivity A special attention is given described as products biomimetic oxidative chemical reactions, which considered models free radical scavenging. During such reactions variety are formed, they completely specific bioactivities compared parent implies exploring scavenging‐related metabolite fingerprint each antioxidant collectively defined here scavengome, will lead deeper compounds. Furthermore, this paper aims working tool systematic studies fingerprints antioxidants, certainly reveal an often‐neglected segment space treasury

Language: Английский

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Caffeoylquinic acids: chemistry, biosynthesis, occurrence, analytical challenges, and bioactivity

The Plant Journal, Journal Year: 2021, Volume and Issue: 107(5), P. 1299 - 1319

Published: June 25, 2021

Caffeoylquinic acids (CQAs) are specialized plant metabolites we encounter in our daily life. Humans consume CQAs mg-to-gram quantities through dietary consumption of products. considered beneficial for human health, mainly due to their anti-inflammatory and antioxidant properties. Recently, new biosynthetic pathways via a peroxidase-type p-coumaric acid 3-hydroxylase enzyme were discovered. More recently, GDSL lipase-like able transform monoCQAs into diCQA was identified Ipomoea batatas. recently linked memory improvement; they seem be strong indirect antioxidants Nrf2 activation. However, there is prevalent confusion the designation nomenclature different CQA isomers. Such inconsistencies critical complicate bioactivity assessment since isomers differ potency. A detailed explanation regarding origin such provided, recommendation unify suggested. Furthermore, studies on bioactivity, plant-based laboratory animal diets contain CQAs, which makes it difficult include proper control groups comparison. Therefore, synthetic diet free advised avoid interferences some may produce even at nanomolar levels. Biotransformation by gut microbiota, discovery enzymatic metabolic pathways, assessment, biological properties with potential drug development areas active, ongoing research. This review focused chemistry, biosynthesis, occurrence, analytical challenges, reported mono-, di-, tri-, tetraCQAs.

Language: Английский

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Gut microbiota in phytopharmacology: A comprehensive overview of concepts, reciprocal interactions, biotransformations and mode of actions

Pharmacological Research, Journal Year: 2019, Volume and Issue: 147, P. 104367 - 104367

Published: July 22, 2019

Language: Английский

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