Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
2024, P. 1 - 19
Published: Jan. 4, 2024
Aegiceras
corniculatum,
commonly
referred
to
as
Khalsi,
is
a
member
of
the
mangrove
Myrsinaceae
family.
The
various
parts
this
plant
have
been
used
in
traditional
medicinal
systems
for
their
potential
therapeutic
effects
conditions
such
asthma,
microbial
infections,
diabetes,
pain
relief,
inflammation,
cancer,
and
arthritis.
A
diverse
array
bioactive
phytochemicals
flavonoids,
benzoquinones,
triterpenes,
polyphenolic
acids,
stilbenes,
tannins,
macrolides
identified
different
plant.
aim
review
was
summarize
phytoconstituents
reported
from
that
are
accountable
observed
pharmacological
further
elucidate
possible
underlying
mechanisms
by
which
these
chemicals
exert
actions.
search
conducted
on
widely
database
platforms,
including
Google
Scholar,
Scopus,
Web
Science,
SciFinder,
PubMed.
Articles
published
until
July
2023
were
extracted
all
information
sorted
based
inclusion
exclusion
criteria.
data
revealed
anti-inflammatory
compounds
suppress
iNOS,
myeloperoxidase,
COX,
LOX,
cytokines
(like
TNF-alpha,
IL-1ß,
LTB4,
IL-12,
IL-6)
reduce
inflammation.
5-O-Butyl-embelin,
2-hydroxy-5-ethoxy-3-nonyl1,
4-benzoquinone,
5-O-methylembelin,
5-O-methyl-rapanone,
s-saponin,
5-O-ethylembelin
some
A.
corniculatum
with
anticancer
properties,
although
mechanism
unclear.
has
antibacterial,
parasitic,
antifungal
effects,
but
no
antiviral
reported.
plant-isolated
coumaric
acid
fatty
acids
interact
bacterial
DNA/RNA
limit
protein
formation,
making
them
antibacterial.
Gallocatechin,
epicatechin,
epigallocatechin-3-O-gallate,
epigallocatechin,
other
well
flavonoids
like
kaempferol,
quercetin,
isorhamnetin,
may
depolarize
change
membranes,
showing
antibacterial
effect.
These
phenolic
also
oxidative
stress
help
treat
cancer
inflammatory
diseases.
extract
activates
κ-opioid
receptor,
causing
central
antinociception.
Catechol
components,
protect
against
CNS
illnesses
Parkinson’s
disease
amnesia.
Despite
numerous
studies
demonstrating
advantages
its
constituents,
number
clinical
trials
humans
remains
significantly
limited.
Molecules,
Journal Year:
2025,
Volume and Issue:
30(5), P. 1088 - 1088
Published: Feb. 27, 2025
Calenduloside
E
(CE)
and
chikusetsusaponin
IVa
(ChIVa)
are
triterpene
saponins
with
multidirectional
bioactivity.
In
this
study,
the
contents
of
CE
ChIVa
were
determined
in
roots,
stems,
leaves,
fruits
ten
wild-growing
species
Amaranthaceae.
To
achieve
optimal
extraction
conditions
for
both
saponins,
maceration,
shaking-assisted
ultrasound-assisted
heat
reflux
compared.
A
sensitive,
specific,
rapid
UPLC-MS/MS
method
was
developed
validated
simultaneous
quantification
ChIVa.
The
results
showed
that
coexisted
most
analyzed,
except
Ch.
hybridum.
For
first
time,
presence
noted
L.
polysperma,
A.
patula,
B.
bonus-henricus,
O.
rubra,
glauca.
Of
highest
content
found
fruit
sagittata
(13.15
mg/g
dw),
polysperma
(12.20
album
(10.0
roots
strictum
(5.52
7.77
dw,
respectively).
amount
(7.84
dw)
(6.54
dw).
These
saponin-abundant
plant
parts
Amaranthaceae
spp.
may
be
considered
convenient
sources
these
bioactive
saponins.
Frontiers in Pharmacology,
Journal Year:
2023,
Volume and Issue:
14
Published: June 21, 2023
Background:Sarcocephalus
pobeguinii
(Hua
ex
Pobég)
is
used
in
folk
medicine
to
treat
oxidative-stress
related
diseases,
thereby
warranting
the
investigation
of
its
anticancer
and
anti-inflammatory
properties.
In
our
previous
study,
leaf
extract
S.
induced
significant
cytotoxic
effect
against
several
cancerous
cells
with
high
selectivity
indexes
towards
non-cancerous
cells.
Aim:
The
current
study
aims
isolate
natural
compounds
from
pobeguinii,
evaluate
their
cytotoxicity,
effects
as
well
searching
for
potential
target
proteins
bioactive
compounds.
Methods:
Natural
were
isolated
leaf,
fruit
bark
extracts
chemical
structures
elucidated
using
appropriate
spectroscopic
methods.
antiproliferative
was
determined
on
four
human
(MCF-7,
HepG2,
Caco-2
A549
cells)
Vero
Additionally,
activity
these
by
evaluating
nitric
oxide
(NO)
production
inhibitory
15-lipoxygenase
(15-LOX)
activity.
Furthermore,
molecular
docking
studies
carried
out
six
putative
found
common
signaling
pathways
inflammation
cancer.
Results:
Hederagenin
(2),
quinovic
acid
3-O-[α-D-quinovopyranoside]
(6)
3-O-[β-D-quinovopyranoside]
(9)
exhibited
all
cells,
they
apoptosis
MCF-7
increasing
caspase-3/-7
showed
highest
efficacy
poor
(except
cells;
while
(2)
safety
a
chemotherapeutic
agent.
Moreover,
significantly
inhibited
NO
LPS-stimulated
RAW
264.7
which
could
mainly
be
attributed
effect.
Besides,
mixture
nauclealatifoline
G
naucleofficine
D
(1),
hederagenin
chletric
(3)
active
15-LOX
compared
quercetin.
Docking
results
that
JAK2
COX-2,
binding
scores,
are
targets
involved
Conclusion:
Overall,
selectively
killed
cancer
additional
effect,
most
prominent
lead
compound
may
further
investigated
drug
candidate
tackle
progression.
BMC Complementary Medicine and Therapies,
Journal Year:
2025,
Volume and Issue:
25(1)
Published: April 24, 2025
Cancer
cases
have
been
on
the
rise
globally
and
several
treatment
strategies
developed
but
mortality
rates
remain
high.
Zimbabwe,
like
many
other
countries,
has
also
experienced
a
surge
in
cancer
cases.
In
medicinal
plants
widely
used
to
treat
for
centuries.
However,
there
limited
research
effectiveness,
safety,
chemical
composition
of
these
plants.
The
current
study
assessed
antiproliferative,
cytotoxic
phytochemical
properties
selected
Zimbabwean
Cytotoxic
activity
Agelenthus
pungu,
Carissa
edulis,
Dombeya
rotundifolia,
Flacourtia
indica,
Lannea
discolor,
Leonotis
ocymifolia,
Leucas
martinicensis,
Plicosepalus
kalachariensis,
Pseudolachnostylis
maproneifolia,
Solanum
incanum,
Strychnos
cocculoides,
spinosa
Viscum
verrucosum
extracts
were
evaluated
normal
murine
peritoneal
cells
sheep
erythrocytes
while
antiproliferative
was
Jurkat
T
HL60
cell
lines.
Cell
viability
determined
using
trypan
blue
exclusion
sulforhodamine
B
assay.
Additionally,
effect
reduced
glutathione
examined.
phytochemicals
methanolic
qualitatively
standard
methods.
cells.
indica
verruscosum
caused
haemolysis
at
concentration
250
µg/mL
both
plant
125
verrucosum.
increased
addition
25
considered
most
extracts,
pungu
martinicensis
significantly
inhibited
proliferation.
potent
with
lowest
half-maximum
inhibitory
(IC50)
values
33
34
lines
respectively.
dominant
classes
alkaloids,
flavonoids
saponins.
This
demonstrates
that
against
potent.
These
findings
emphasise
importance
as
well
their
potential
use
sources
novel
compounds
anticancer
drug
discovery.
