Recent advancement of novel marine fungi derived secondary metabolite fibrinolytic compound FGFC in biomedical applications: a review DOI Creative Commons

Lakshmi Jeevithan,

Xiaozhen Diao,

Jiudong Hu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 18, 2024

For several decades, products derived from marine natural sources (PMN) have been widely identified for therapeutic applications due to their rich of bioactive sub-stances, unique chemical diversity, biocompatibility and excellent biological activity. the past 15 years, our research team explored PMNs, especially fungi fibrinolytic compounds (FGFCs). FGFC is an isoindolone alkaloid fungi, also known as staplabin analogs or Stachybotrys microspora triprenyl phenol (SMTP). instance, previous studies different types FGFCs such 1, 2, 3 4 longispora FG216 metabolites. The derivatives are potentially employed in disease treatments, mainly stroke, cancer, ischemia, acute kidney injury, inflammation, cerebral infarction, thrombolysis hemorrhagic activities, etc. Due increasing use pharmaceutical biomedical applications, it important understand fundamental signaling concept FGFCs. Hence, first time, this review collectively summarizes background, types, mode action current endeavors future therapies.

Language: Английский

Formation of N-Hydroxyethylisoindolinone Derivatives in Fungi Requires Highly Coordinated Consecutive Oxidation Steps DOI Creative Commons
LI Zhang-hai,

Yu Dai,

Jing Zhou

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Gene duplication significantly contributes to the diversification of biosynthetic potential and increases structural diversity secondary metabolites. Here, we report second alkyl salicylaldehyde derivative gene cluster in Penicillium roqueforti, being responsible for formation ethanolamine-containing derivatives. Heterologous expression feeding experiments provided evidence their via collaboration modification with one cytochrome P450 two flavin-containing monooxygenases a highly ordered manner before after ethanolamine incorporation.

Language: Английский

Citations

0
Recent advancement of novel marine fungi derived secondary metabolite fibrinolytic compound FGFC in biomedical applications: a review DOI Creative Commons

Lakshmi Jeevithan,

Xiaozhen Diao,

Jiudong Hu

et al.

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 18, 2024

For several decades, products derived from marine natural sources (PMN) have been widely identified for therapeutic applications due to their rich of bioactive sub-stances, unique chemical diversity, biocompatibility and excellent biological activity. the past 15 years, our research team explored PMNs, especially fungi fibrinolytic compounds (FGFCs). FGFC is an isoindolone alkaloid fungi, also known as staplabin analogs or Stachybotrys microspora triprenyl phenol (SMTP). instance, previous studies different types FGFCs such 1, 2, 3 4 longispora FG216 metabolites. The derivatives are potentially employed in disease treatments, mainly stroke, cancer, ischemia, acute kidney injury, inflammation, cerebral infarction, thrombolysis hemorrhagic activities, etc. Due increasing use pharmaceutical biomedical applications, it important understand fundamental signaling concept FGFCs. Hence, first time, this review collectively summarizes background, types, mode action current endeavors future therapies.

Language: Английский

Citations

0