Journal of Applied Pharmaceutical Research,
Journal Year:
2024,
Volume and Issue:
12(6), P. 88 - 99
Published: Dec. 31, 2024
Background:
Medicinal
herbs
have
long
been
used
for
treating
various
ailments,
with
plant-derived
compounds
recognized
their
therapeutic
benefits
and
minimal
side
effects
compared
to
conventional
medicines.
However,
issues
the
bioavailability
of
active
herbal
components
limited
effectiveness.
Phytosomes,
or
herbosomes,
are
a
drug
delivery
technology
that
enhances
absorption
these
plant-based
compounds,
providing
potential
solution
maximizing
medicinal
efficacy
ingredients.
Method:
Phytosome
complexes
synthesized
by
combining
plant
extracts
phospholipids
in
specific
molar
ratios,
typically
1:1,
create
more
stable
bioavailable
formulation.
Common
preparation
methods
include
solvent
evaporation,
supercritical
fluid
extraction,
lyophilization.
Each
technique
is
optimized
improve
stability,
solubility,
action
phytosomes.
Results
discussion:
has
shown
significant
improvements
phytochemicals,
such
as
silymarin
curcumin,
enhancing
pharmacological
effects.
Applications
phytosomes
span
areas,
including
cancer
treatment,
rheumatism,
wound
healing,
respiratory
conditions.
Studies
indicate
absorption,
targeted
delivery,
effectively
managing
complex
diseases
reduced
Conclusion:
Phytosomes
represent
promising
advancement
natural
medicine
addressing
challenges
associated
compounds.
The
improved
formulation
techniques
broad
applications
suggest
bright
future
phytosome-based
therapies,
especially
areas
where
treatments
may
limitations.
Further
research
development
phytosome
could
lead
enhanced
clinical
outcomes
expand
use
remedies
modern
medicine.
Reproduction in Domestic Animals,
Journal Year:
2025,
Volume and Issue:
60(4)
Published: April 1, 2025
ABSTRACT
This
study
investigated
the
potential
of
incorporating
curcumin
oil
nano‐emulsion
(CONE)
into
a
Tris‐based
freezing
extender
to
relieve
cryodamage
effects
and
enhance
sperm
cryo‐resistance
in
buffalo
bulls.
Pooled
semen
from
five
fertile
bulls
(
n
=
40
ejaculates)
was
divided
supplemented
with
0.5%
CONE
(CONE0.5),
1%
(CONE1),
or
without
(CONE0,
control),
then
extended
packaged.
Post‐thaw
assessments
included
kinematic
parameters,
oxidative
stress
markers,
apoptosis
levels,
microbial
load,
ultrastructural
integrity,
molecular
docking
interactions,
conception
rates.
The
CONE0.5
group
exhibited
significantly
higher
viability,
progressive
motility,
membrane
as
well
lower
nitric
oxide
MDA
compared
CONE0
CONE1
groups
p
<
0.05),
indicating
reduced
stress.
Compared
group,
percentage
viable
early
apoptotic
sperm,
late
0.05).
Both
CONE‐treated
demonstrated
post‐thaw
total
bacterial,
spore‐forming
coliform
bacterial
counts
Conception
rates
were
(80.0%)
(68.0%)
>
Molecular
analysis
revealed
strong
binding
affinities
between
caspase‐3
(−7.87
kcal/mol),
HSP70
(−8.52
PRDX‐1
(−8.90
suggesting
mechanisms
action.
In
summary,
inclusion
cryoprotective
additive
media
demonstrates
for
improving
quality
possible
enhancement
reproductive
efficiency.
Phytotherapy Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 20, 2025
ABSTRACT
A
complete
investigation
into
phytosome‐based
formulations
and
innovative
nanotechnology
is
presented
in
this
review.
This
aims
to
improve
the
bioavailability
therapeutic
effectiveness
of
herbal
components.
Phytosomes
can
significantly
increase
solubility,
absorption,
stability
compared
standard
by
encapsulating
active
phytoconstituents
phospholipid
complexes.
unique
ability
phytosomes
overcome
limits
traditional
a
potential
game
changer
medicine.
study
highlights
different
uses
across
various
health
disorders,
such
as
neurodegenerative
illnesses,
inflammatory
conditions,
diabetes,
cardiovascular
diseases,
wound
healing.
The
review
also
discusses
treating
infectious
diseases
improving
delivery
bioactive
compounds
that
have
improved
anticancer
efficacy
antibacterial
properties.
Despite
emergence
numerous
groundbreaking
discoveries,
substantial
barriers
remain
hinder
their
widespread
application.
Challenges
must
be
addressed
include
stability,
large‐scale
manufacture,
regulatory
hurdles,
limited
clinical
translation.
examines
limitations
present
practice,
mainly
focusing
on
variability
bioavailability.
crucial
need
for
future
research
phytosomes,
engaging
researchers
emphasizing
continuous
evolution
promising
area
BIO Integration,
Journal Year:
2025,
Volume and Issue:
6(1)
Published: Jan. 1, 2025
Lipid-based
Nanoparticles
(LBNPs)
have
emerged
as
a
transformative
approach
in
cancer
treatment,
offering
innovative
drug
delivery
solutions
that
enhance
therapeutic
efficacy
while
minimizing
adverse
effects.
By
exploring
the
characterization,
classification,
synthesis,
targeting
strategies,
and
advantages
of
LBNPs,
this
study
highlights
how
LBNPs
been
used
to
overcome
limitations
traditional
chemotherapy
improve
patient
outcomes.
As
nanotechnology
revolutionizes
therapy,
emergence
promising
strategy
for
targeted
has
led
optimism
regarding
future
treatment.
This
review
extensively
assesses
structure,
categories,
production
methods,
benefits,
recent
advancements
treating
cancer.
It
also
current
challenges
possible
directions.
is
aimed
at
providing
comprehensive
understanding
LBNPs’
potential
therapy.
Liposomes,
nanostructured
lipid
carriers,
solid
nanoparticles,
lipid-polymer
hybrid
nanoparticles
are
all
types
each
with
unique
features
interest
These
particles
can
be
synthesized
through
various
procedures,
such
bulk
nanoprecipitation,
solvent-based
emulsification,
or
microfluidics.
Passive
systems,
active
responsive
platforms
direct
tumors.
Consequently,
provide
an
improved
release
pattern
minimizes
side
effects
enhancing
efficacy.
With
combination
offer
hopeful
Continued
research
expected
outcomes
overall
quality
life
care.
Sustainable Food Technology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
AI
significantly
transforms
the
food
business
by
optimizing
production
processes
of
therapeutic
Ganoderma
spp.
and
improving
quality
safety
control
based
functional
food.
