A Personalised Pacing and Active Rest Rehabilitation Programme for Post-Exertional Symptom Exacerbation and Health Status in Long COVID (PACELOC): A Prospective Cohort Study DOI Open Access

Belinda Godfrey,

Jenna Shardha,

Sharon Witton

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(1), P. 97 - 97

Published: Dec. 27, 2024

Background: Post-COVID-19 Syndrome or long COVID (LC) is a novel public health crisis and, when persistent (>2 years), long-term condition. Post-exertional symptom exacerbation (PESE) characteristic of LC and can be improved in structured pacing rehabilitation programme. Aims: To evaluate the effect an 8-week World Health Organisation (WHO) Borg CR-10 protocol on PESE episodes, symptoms, quality life cohort individuals with LC. Methods: Participants received weekly telephone calls clinician to discuss their activity phase, considering symptoms that week. They completed Leeds questionnaire (LPQ), C19-YRS (Yorkshire Rehabilitation Scale), EQ-5D-5L at beginning programme (0 weeks), end (8 final follow-up (12 weeks). Results: Thirty-one participants (duration symptoms: 29 months) The episodes decreased number each week (15% fewer week, 95% CI: 11% 20%, p < 0.001) were shorter duration milder severity changes C19YRS functional disability (0–12 weeks) statistically significant but not clinically significant. EQ5D-5L index score change was Conclusions: A effectively reduced episode frequency, duration, did produce reflecting nature condition this cohort.

Language: Английский

Erkrankte mit ärztlich diagnostizierter Myalgischer Enzephalomyelitis/chronischem Fatigue-Syndrom (ME/CFS-) im Vergleich zu Erkrankten, die vermuten an ME/CFS zu leiden DOI
Lotte Habermann-Horstmeier, Lukas M. Horstmeier

Prävention und Gesundheitsförderung, Journal Year: 2025, Volume and Issue: unknown

Published: March 5, 2025

Citations

1
Health-related quality of life in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post COVID-19 Condition: a systematic review DOI Creative Commons
Breanna Weigel, Maira Inderyas, Natalie Eaton-Fitch

et al.

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 13, 2025

Abstract Purpose Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Post COVID-19 Condition (PCC) are debilitating, chronic multi-systemic illnesses that require multidisciplinary care. However, people with ME/CFS (pwME/CFS) PCC (pwPCC) often precluded from accessing necessary disability social support services. These unmet care needs exacerbate the existing illness burdens experienced by pwME/CFS pwPCC. To deliver appropriate optimise health outcomes for pwPCC, development of evidence-based healthcare policies recognise disabling impacts these must be prioritised. This systematic review summarises health-related quality life (HRQoL) pwPCC when compared healthy controls (HCs) to elucidate guide policy reform. Methods CINAHL, Embase, MEDLINE, PubMed, PsycINFO Web Science Core Collection were systematically searched 1st January 2003 23rd July 2024. Eligible publications included observational studies capturing quantitative HRQoL data among or HCs. The use validated patient-reported outcome measures (PROMs) was mandatory. also required employ most stringent diagnostic criteria currently available, including Canadian Consensus Criteria International World Health Organization case definition (PROSPERO ID: CRD42024501309). Results captured 16 studies, eight pwME/CFS, seven one study both cohorts. Most participants female middle-aged. All had prolonged symptoms at least three months. When HCs, all domains significantly impaired Both a salient impact on physical health, pain ability perform daily work activities. While direct comparisons between limited inconsistencies in PROMs employed, comparable trends across domain scores observed. Conclusion have similar, profound warrant access Future research harmonise collection prioritise longitudinal investigations characterise subgroups (including those fulfilling criteria) predictors prognosis.

Language: Английский

Citations

0
Variant connective tissue as a risk factor for Long COVID: a case-control study DOI Creative Commons
Lisa Quadt,

Regina A. Torok,

Jeffrey Lubell

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: March 20, 2025

Abstract Long COVID (LC) is a major medical challenge, with approximately 20 million sufferers in the US and UK alone. Determining risk factors for LC of utmost importance to aid effective preventative treatment. We assessed whether variant connective tissue, known factor several illnesses, predictive risk. administered survey 1,816 respondents recruited from representative online panels assessing joint hypermobility status. In separate well-controlled binomial logistic regressions, both generalized (OR 1.29, 95% CI 1.00 1.65) extreme 2.12, 1.43 3.16) were LC. Our findings suggest that influences odds developing by increasing likelihood severe initial symptoms COVID-19 individuals no or moderate experience

Language: Английский

Citations

0
Long COVID in 2025: a clinical viewpoint DOI
Andrew Schamess, Markus Velten,

Aaron Friedberg

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123633 - 123633

Published: April 1, 2025

Language: Английский

Citations

0
A pilot cross-sectional investigation of symptom clusters and associations with patient-reported outcomes in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Post COVID-19 Condition DOI Creative Commons
Breanna Weigel, Natalie Eaton-Fitch, Kiran Thapaliya

et al.

Quality of Life Research, Journal Year: 2024, Volume and Issue: 33(12), P. 3229 - 3243

Published: Oct. 3, 2024

Abstract Background Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is associated with long-term disability and poor quality of life (QoL). Cardinal ME/CFS symptoms (including post-exertional malaise, cognitive dysfunction sleep disturbances) have been observed in Post COVID-19 Condition (PCC). To gain further insight into the potential role as a post-COVID-19 sequela, this study investigates associations between patient-reported outcomes, well symptom clusters. Methods Participants included Australian residents aged 18 65 years formally diagnosed fulfilling Canadian or International Consensus Criteria PCC meeting World Health Organization case definition. Validated, self-administered questionnaires collected participants’ sociodemographic illness characteristics, symptoms, QoL functional capacity. Associations outcomes were investigated multivariate linear regression models. Hierarchical cluster analysis was performed to identify Results Most people (pwME/CFS) (pwPCC) female ( n = 48/60, 80.0% 19/30, 63.3%, respectively; p 0.12). PwME/CFS significantly younger x̄ =41.75, s 12.91 years) than pwPCC =48.13, =10.05 years; =0.017). Autonomic (notably dyspnoea) poorer scores most outcome domains for both cohorts. None four clusters identified unique PCC. Clusters largely delineated by presence gastrointestinal neurosensory duration, criteria met total symptoms. Conclusions Illness duration may explain differences burden pwME/CFS pwPCC. diagnostic must be refined distinguish at risk ME/CFS-like subsequently deliver necessary care support.

Language: Английский

Citations

0
Effects of a symptom-titrated exercise program on fatigue and quality of life in people with post-COVID condition – a randomized controlled trial DOI Creative Commons
Andreas Barz, Joshua Berger,

Marco Speicher

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Dec. 16, 2024

Language: Английский

Citations

0
A Personalised Pacing and Active Rest Rehabilitation Programme for Post-Exertional Symptom Exacerbation and Health Status in Long COVID (PACELOC): A Prospective Cohort Study DOI Open Access

Belinda Godfrey,

Jenna Shardha,

Sharon Witton

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(1), P. 97 - 97

Published: Dec. 27, 2024

Background: Post-COVID-19 Syndrome or long COVID (LC) is a novel public health crisis and, when persistent (>2 years), long-term condition. Post-exertional symptom exacerbation (PESE) characteristic of LC and can be improved in structured pacing rehabilitation programme. Aims: To evaluate the effect an 8-week World Health Organisation (WHO) Borg CR-10 protocol on PESE episodes, symptoms, quality life cohort individuals with LC. Methods: Participants received weekly telephone calls clinician to discuss their activity phase, considering symptoms that week. They completed Leeds questionnaire (LPQ), C19-YRS (Yorkshire Rehabilitation Scale), EQ-5D-5L at beginning programme (0 weeks), end (8 final follow-up (12 weeks). Results: Thirty-one participants (duration symptoms: 29 months) The episodes decreased number each week (15% fewer week, 95% CI: 11% 20%, p < 0.001) were shorter duration milder severity changes C19YRS functional disability (0–12 weeks) statistically significant but not clinically significant. EQ5D-5L index score change was Conclusions: A effectively reduced episode frequency, duration, did produce reflecting nature condition this cohort.

Language: Английский

Citations

0