Interconnections between Inflammageing and Immunosenescence during Ageing

Cells, Journal Year: 2022, Volume and Issue: 11(3), P. 359 - 359

Published: Jan. 21, 2022

Acute inflammation is a physiological response to injury or infection, with cascade of steps that ultimately lead the recruitment immune cells clear invading pathogens and heal wounds. However, chronic arising from continued presence initial trigger, dysfunction signalling and/or effector pathways, harmful health. While successful ageing in older adults, including centenarians, associated low levels inflammation, elevated increases risk poor health death. Hence has been described as one seven pillars ageing. Age-associated sterile, chronic, low-grade commonly termed inflammageing-it not simply consequence increasing chronological age, but also marker biological ageing, multimorbidity, mortality risk. inflammageing was initially thought be caused by "continuous antigenic load stress", reports last two decades describe much more complex phenomenon involving cellular senescence system. In this review, we explore some main sources consequences context immunosenescence highlight potential interventions. particular, assess contribution age-associated identify patterns pro- anti-inflammatory markers characteristic inflammageing, alterations system finally ways diet, exercise, pharmacological interventions can reduce thus, improve later life

Language: Английский

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Adult- and late-onset male hypogonadism: the clinical practice guidelines of the Italian Society of Andrology and Sexual Medicine (SIAMS) and the Italian Society of Endocrinology (SIE)

Journal of Endocrinological Investigation, Journal Year: 2022, Volume and Issue: 45(12), P. 2385 - 2403

Published: Aug. 26, 2022

Language: Английский

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COVID-19 and endocrine and metabolic diseases. An updated statement from the European Society of Endocrinology

Endocrine, Journal Year: 2021, Volume and Issue: 72(2), P. 301 - 316

Published: May 1, 2021

COVID-19 has completely changed our daily clinical practice as well social relations. Many organs and biological systems are involved in SARS-Cov-2 infection, either due to direct virus-induced damage or indirect effects that can have systemic consequences. Endocrine system is not only an exception but its involvement so relevant "endocrine phenotype" of progressively acquired relevance.

Language: Английский

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Testosterone in males with COVID‐19: A 7‐month cohort study

Andrology, Journal Year: 2021, Volume and Issue: 10(1), P. 34 - 41

Published: Aug. 19, 2021

Circulating testosterone levels have been found to be reduced in men with severe acute respiratory syndrome coronavirus 2 infection, COVID-19, lower being associated more clinical outcomes.We aimed assess total and the prevalence of still suggesting for hypogonadism at 7-month follow-up a cohort 121 who recovered from laboratory-confirmed COVID-19.Demographic, clinical, hormonal values were collected all patients. Hypogonadism was defined as ≤9.2 nmol/L. The Charlson Comorbidity Index used score health-significant comorbidities. Descriptive statistics multivariable linear logistic regression models tested association between laboratory variables assessment.Circulating increased compared hospital admittance (p < 0.0001), while luteinizing hormone 17β-estradiol significantly decreased (all p ≤ 0.02). Overall, 106 (87.6%) patients, but further 12 (9.9%) patients follow-up, where level suggestive observed 66 (55%) Baseline (OR 0.36; = 0.03 [0.14, 0.89]) independently after adjusting age, BMI, IL-6 admittance.Although over time than 50% disease had circulating condition follow-up. In many 10% cases, even decreased. Of relevance, higher burden comorbid conditions presentation, probability recovery time.

Language: Английский

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Role of the Renin–Angiotensin–Aldosterone and Kinin–Kallikrein Systems in the Cardiovascular Complications of COVID-19 and Long COVID

International Journal of Molecular Sciences, Journal Year: 2021, Volume and Issue: 22(15), P. 8255 - 8255

Published: July 31, 2021

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is the virus responsible for COVID-19 pandemic. Patients may present as asymptomatic or demonstrate mild to severe and life-threatening symptoms. Although has a respiratory focus, there are major cardiovascular complications (CVCs) associated with infection. The reported CVCs include myocarditis, heart failure, arrhythmias, thromboembolism blood pressure abnormalities. These occur, in part, because of dysregulation Renin–Angiotensin–Aldosterone System (RAAS) Kinin–Kallikrein (KKS). A route by which SARS-CoV-2 gains cellular entry via docking viral spike (S) protein membrane-bound angiotensin converting enzyme (ACE2). roles ACE2 within immune systems vital ensure homeostasis. key routes development recently described long COVID have been hypothesised direct consequences S protein/ACE2 axis, downregulation resulting damage inflicted response. Here, we review impact on system, mechanisms RAAS KKS can occur following infection future implications pharmacological therapies.

Language: Английский

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COVID-19-Related Mortality Risk in People With Severe Mental Illness: A Systematic and Critical Review

Frontiers in Psychiatry, Journal Year: 2022, Volume and Issue: 12

Published: Jan. 13, 2022

Background: Increasing clinical evidence suggests that people with severe mental illness (SMI), including schizophrenia spectrum disorders, bipolar disorder (BD), and major depressive (MDD), are at higher risk of dying from COVID-19. Several systematic reviews examining the association between psychiatric disorders COVID-19-related mortality have recently been published. Although these conducted thoroughly, certain methodological limitations may hinder accuracy their research findings. Methods: A literature search, using PubMed, Embase, Web Science, Scopus databases (from inception to July 23, 2021), was for observational studies assessing death associated COVID-19 infection in adult patients pre-existing BD, or MDD. Methodological quality included assessed Newcastle-Ottawa Scale (NOS). Results: Of 1,446 records screened, 13 articles investigating rates SMI were this review. Quality assessment scores ranged moderate high. Most results seem indicate SMI, particularly significantly mortality, as compared without SMI. However, extent variation large because a low level precision estimated outcome(s) studies. on MDD BD did not include specific information mood state disease severity patients. Due lack data, it remains unknown what increased mortality. variety factors likely contribute These male sex, older age, somatic comorbidities (particularly cardiovascular diseases), well disease-specific characteristics. Conclusion: hamper estimates main categories SMIs. Nevertheless, is excess Policy makers therefore must consider vulnerable individuals high-risk group should be given particular attention. This means targeted interventions maximize vaccination uptake among required address burden already disadvantaged group.

Language: Английский

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Universal healthcare as pandemic preparedness: The lives and costs that could have been saved during the COVID-19 pandemic

Proceedings of the National Academy of Sciences, Journal Year: 2022, Volume and Issue: 119(25)

Published: June 13, 2022

The fragmented and inefficient healthcare system in the United States leads to many preventable deaths unnecessary costs every year. During a pandemic, lives saved economic benefits of single-payer universal relative status quo would be even greater. For Americans who are uninsured underinsured, financial barriers COVID-19 care delayed diagnosis exacerbated transmission. Concurrently, beyond accrued from background rate uninsurance. Universal alleviate mortality caused by confluence these factors. To evaluate repercussions incomplete insurance coverage 2020, we calculated elevated attributable loss employer-sponsored rates uninsurance, summing with increased due low coverage. Incorporating demography age-specific nonpandemic mortality, estimated that have about 212,000 2020 alone. We also US$105.6 billion medical expenses associated hospitalization could been averted over course pandemic. These addition US$438 expected during

Language: Английский

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Andrological effects of SARS-Cov-2 infection: a systematic review and meta-analysis

Journal of Endocrinological Investigation, Journal Year: 2022, Volume and Issue: 45(12), P. 2207 - 2219

Published: May 9, 2022

The short- and long-term andrological effects of coronavirus disease 2019 (COVID-19) have not been clarified. Our aim is to evaluate the available evidence regarding possible consequences COVID-19 either on seminal or hormonal parameters. safety vaccines in terms sperm quality was also investigated.All prospective retrospective observational studies reporting information severe acute respiratory syndrome 2 (SARS-Cov-2) mRNA semen male genitalia tract detection (n = 19), as well those data analysis 5) parameters 11) infected/recovered patients without any arbitrary restriction were included.Out 204 retrieved articles, 35 considered, including 2092 1138 controls with a mean age 44.1 ± 12.6 years, follow-up 24.3 18.9 days. SARS-CoV-2 can be localized tracts during phase disease. result short-term impaired T production. Available cannot clarify effects. Low observed associated an increased risk being admitted Intensive Care Unit death. two showed that use does affect quality.The results our clearly suggest each patient recovering from should monitored rule out abnormalities. specific contribution reduced levels infection needs better

Language: Английский

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Syndemics and clinical science

Nature Medicine, Journal Year: 2022, Volume and Issue: 28(7), P. 1359 - 1362

Published: July 1, 2022

Language: Английский

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Serum sodium alterations in SARS CoV-2 (COVID-19) infection: impact on patient outcome

European Journal of Endocrinology, Journal Year: 2021, Volume and Issue: 185(1), P. 137 - 144

Published: May 5, 2021

Hyponatremia is the most common electrolyte disorder in hospitalized patients and occurs about 30% of with pneumonia. has been associated a worse outcome several pathologic conditions The main objective this study was to determine whether serum sodium alterations may be independent predictors COVID-19 patients.In observational study, data from 441 laboratory-confirmed admitted University Hospital were collected. After excluding 61 (no at admission available, saline solution infusion before assessment, transfer another hospital), 380 analyzed.274 (72.1%) had normonatremia admission, 87 (22.9%) hyponatremia 19 (5%) hypernatremia. We found an inverse correlation between IL-6, whereas direct PaO2/FiO2 ratio observed. Patients higher prevalence non-invasive ventilation ICU than those or predictor in-hospital mortality (2.7-fold increase vs normonatremia) each mEq/L reduction 14.4% increased risk death.These results suggest that considered as early prognostic marker disease severity patients.

Language: Английский

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