Toxins,
Journal Year:
2024,
Volume and Issue:
16(6), P. 242 - 242
Published: May 26, 2024
Both
physical
inactivity
and
disruptions
in
the
gut
microbiome
appear
to
be
prevalent
patients
with
chronic
kidney
disease
(CKD).
Engaging
activity
could
present
a
novel
nonpharmacological
strategy
for
enhancing
mitigating
adverse
effects
associated
microbial
dysbiosis
individuals
CKD.
This
narrative
review
explores
underlying
mechanisms
through
which
may
favorably
modulate
health,
either
direct
impact
on
or
interorgan
crosstalk.
Also,
development
of
its
interplay
CKD
are
discussed.
Mechanisms
interventions
restore
homeostasis
explored.
Diabetes,
Journal Year:
2023,
Volume and Issue:
72(8), P. 1070 - 1082
Published: May 24, 2023
Exercise
is
a
first-line
treatment
for
type
2
diabetes
and
preserves
β-cell
function
by
hitherto
unknown
mechanisms.
We
postulated
that
proteins
from
contracting
skeletal
muscle
may
act
as
cellular
signals
to
regulate
pancreatic
function.
used
electric
pulse
stimulation
(EPS)
induce
contraction
in
C2C12
myotubes
found
of
β-cells
with
EPS-conditioned
medium
enhanced
glucose-stimulated
insulin
secretion
(GSIS).
Transcriptomics
subsequent
targeted
validation
revealed
growth
differentiation
factor
15
(GDF15)
central
component
the
secretome.
Exposure
recombinant
GDF15
GSIS
cells,
islets,
mice.
upregulating
pathway
β-cells,
which
was
abrogated
presence
neutralizing
antibody.
The
effect
on
also
observed
islets
GFRAL-deficient
Circulating
incrementally
elevated
patients
pre-
positively
associated
C-peptide
humans
overweight
or
obesity.
Six
weeks
high-intensity
exercise
training
increased
circulating
concentrations,
correlated
improvements
diabetes.
Taken
together,
can
contraction-induced
protein
enhances
through
activating
canonical
signaling
GFRAL-independent
manner.
Article
Highlights
improves
direct
interorgan
communication.
Contracting
releases
(GDF15),
required
synergistically
enhance
secretion.
release
pathway.
Increased
levels
after
are
related
Physiologia,
Journal Year:
2025,
Volume and Issue:
5(1), P. 2 - 2
Published: Jan. 2, 2025
Pregnancy
is
followed
by
complex
and
intense
physiological
changes
in
the
maternal
body,
whose
goal
to
provide
all
needs
of
mother
growing
fetus.
The
endocrine
system
thermoregulation
integrate
physiologic
responses
play
an
important
role
maintaining
homeostatic
conditions
during
exercise
pregnancy.
Changes
adaptations
pregnancy
are
conditioned
influence
numerous
metabolic
biochemical
events,
which
act
on
target
tissues
through
mechanisms.
Many
hormones
released
a
variety
cells
responsible
for
number
different
responses.
involves
that
lead
increase
heat
production
its
preservation.
Physiological
mechanisms
enable
release
excess
body
temperature
order
maintain
ideal
increased,
such
as
sweating
vasodilation
blood
vessels.
reaction
training
depends
duration
intensity
training,
nutrient
profile,
level
fitness.
Exercise
has
many
improving
effects
functional
aspects
organs,
resulting
improved
health
and/or
performance.
Sports,
Journal Year:
2023,
Volume and Issue:
11(4), P. 74 - 74
Published: March 27, 2023
Hemostatic
balance
refers
to
the
dynamic
between
blood
clot
formation
(coagulation),
dissolution
(fibrinolysis),
anticoagulation,
and
innate
immunity.
Although
regular
habitual
exercise
may
lower
incidence
of
cardiovascular
diseases
(CVD)
by
improving
an
individual’s
hemostatic
profile
at
rest
during
exertion,
vigorous
increase
risk
sudden
cardiac
death
venous
thromboembolism
(VTE).
This
literature
review
aims
investigate
system’s
acute
chronic
adaptive
responses
different
types
in
healthy
patient
populations.
Compared
athletes,
sedentary
individuals
demonstrate
similar
post-exercise
platelet
function
coagulatory
fibrinolytic
potential.
However,
adaptations
patients
with
training
is
a
promising
field.
Despite
increased
thrombotic
events
bout
exercise,
exposure
high-intensity
might
desensitize
exercise-induced
aggregation,
moderate
parameters,
up-regulate
potential
via
increasing
tissue
plasminogen
activator
(tPA)
decreasing
inhibitor
(PAI-1)
response.
Future
research
focus
on
combining
manipulating
each
characteristic
(frequency,
intensity,
time,
volume),
or
investigating
minimal
dosage
required
maintain
balance,
especially
various
health
conditions.
Free Radical Biology and Medicine,
Journal Year:
2024,
Volume and Issue:
223, P. 53 - 68
Published: July 24, 2024
Skeletal
muscle
plasticity
enables
an
enormous
potential
to
adapt
various
internal
and
external
stimuli
perturbations.
Most
notably,
changes
in
contractile
activity
evoke
a
massive
remodeling
of
biochemical,
metabolic
force-generating
properties.
In
recent
years,
large
number
signals,
sensors,
regulators
effectors
have
been
implicated
these
adaptive
processes.
Nevertheless,
our
understanding
the
molecular
underpinnings
training
adaptation
remains
rudimentary.
Specifically,
mechanisms
that
underlie
signal
integration,
output
coordination,
functional
redundancy
other
complex
traits
are
unknown.
fact,
it
is
even
unclear
how
stimulus-dependent
specification
brought
about
endurance
or
resistance
exercise.
this
review,
we
will
provide
overview
on
events
describe
acute
perturbations
single
exercise
bouts.
Furthermore,
insights
into
principles
long-term
adaptation.
Finally,
current
gaps
knowledge
be
identified,
strategies
for
multi-omic
–cellular
analyses
skeletal
engaged
individual,
bouts
chronic
discussed.
Sportphysio,
Journal Year:
2025,
Volume and Issue:
13(01), P. 51 - 54
Published: Feb. 1, 2025
Treten
bei
Sportlerinnen
gesundheitliche
Beschwerden
auf,
betrachten
viele
Ärztinnen
und
Ärzte
sie
durch
die
Brille
der
traditionellen,
von
männlichen
Sichtweisen
geprägten
Medizin.
Aber
Frauen
sind
keine
„kleinen
Männer“.
Gesundheitliche
können
sich
ihnen
völlig
anders
darstellen,
auch
Behandlung
muss
man
Besonderheiten
des
weiblichen
Stoffwechsels
Hormonhaushalts
beachten.
Ein
fiktives
Fallbeispiel.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 3, 2025
This
study
aimed
to
examine
the
associations
between
substituting
sedentary
time
(ST)
with
physical
activity
and
sleep
obesity
parameters
in
adults
from
eight
Latin
American
countries.
The
sample
consisted
of
2173
aged
18–65
years.
Physical
activity,
ST
were
objectively
measured
using
accelerometers.
defined
body
mass
index
(BMI)
waist
circumference
(WC).
Regression
analyses
conducted
for
isotemporal
analysis
association
30
min/day
light
(LPA),
moderate
vigorous
(MVPA)
relation
BMI
WC.
Substituting
higher
intensity
was
also
analyzed.
MVPA
significantly
associated
lower
odds
a
(OR:
0.993,
95%CI
0.990–0.998)
WC
0.998,
0.998–0.999).
Conversely,
LPA
did
not
show
significant
impact
on
parameters.
However,
substitution
0.989–0.997).
results
highlight
importance
replacing
increasing
as
an
effective
strategy
preventing
managing
America.
