A Novel Metabolic Risk Classification System Incorporating Body Fat, Waist Circumference, and Muscle Strength DOI Creative Commons

Carlos Raúl Robledo-Millán,

María Regina Diaz-Domínguez,

Ari Evelyn Castañeda-Ramírez

et al.

Journal of Functional Morphology and Kinesiology, Journal Year: 2025, Volume and Issue: 10(1), P. 72 - 72

Published: Feb. 22, 2025

Background: As metabolic diseases continue to rise globally, there is a growing need improve risk assessment strategies beyond traditional measures such as BMI and waist circumference, which may fail identify individuals at risk. This study develops validates novel classification system that incorporates body fat percentage (%BF), circumference (WC), grip strength (GS) in Mexican adults. It aims stratification evaluate the association with syndrome. Methods: cross-sectional involved 300 young adults (18–22 years) from university Mexico City, utilizing composition (%BF) anthropometric (WC, GS) categorize them into four groups: protective, low risk, increased high A retrospective cohort of 166 (18–65 complete clinical records was used for validation. Results: The inclusion GS significantly shifted distribution adult cohort, reducing “no risk” category (15.5% males, 11.6% females) expanding higher-risk categories (70.2% 69% females). Metabolic parameters fasting glucose, triglycerides, HDL cholesterol, blood pressure worsened progressively across (p < 0.001). high-risk group exhibited markedly odds ratio syndrome 28.23 (10.83–73.6, p 0.001), no cases protective low-risk groups. Conclusions: Integrating %BF WC substantially enhances stratification, identifies at-risk not previously detected, confirms group. validated provides robust tool early detection targeted interventions, improving public health outcomes health.

Language: Английский

Cardiometabolic risk stratification using a novel obesity phenotyping system based on body adiposity and waist circumference DOI Creative Commons
Javier Gómez‐Ambrosi, Victoria Catalán, Beatriz Ramírez

et al.

European Journal of Internal Medicine, Journal Year: 2024, Volume and Issue: 124, P. 54 - 60

Published: March 6, 2024

BackgroundThe estimation of obesity-associated cardiometabolic risk does not usually take into account body composition or the distribution adiposity. The aim present study was to assess clinical usefulness a novel obesity phenotyping system based on combination actual fat percentage (BF%) and waist circumference (WC) according estimation.MethodsA classification matrix combining BF% WC as measures both amount adiposity establishing nine phenotypes (3 x 3 WC) developed. Individuals were grouped in five different phenotypes. We conducted validation large cohort White subjects from genders representing wide range ages (n = 12,754; 65 % females, aged 18–88 years).ResultsThe groups using exhibited robust linear regarding risk, estimated by Metabolic Syndrome Severity Score, showing continuous increase between with significant differences (P < 0.001) among them, well other factors. An additional 24 patients at very high detected new proposed compared an equivalent BMI instead WC.ConclusionsA more detailed should be priority diagnosis management obesity. Our allows gradually estimate WC, thus useful tool for research practice.

Language: Английский

Citations

8
Atherogenic Index of Plasma as a Mediator in the association between Body Roundness Index and Depression: insights from NHANES 2005–2018 DOI Creative Commons
Genshan Zhang,

Haokun Zhang,

Jie Fu

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: June 12, 2024

Abstract Background Previous studies have shown a correlation between depression and obesity, as well the Atherogenic Index of Plasma (AIP). However, there is limited research on association visceral obesity depression, potential mediating role AIP in this relationship. Methods This study included 13,123 participants from 2005–2018 National Health Nutrition Examination Survey. Visceral was measured with Body Roundness (BRI), while evaluated Patient Questionnaire-9. The served marker for lipid disorders. To investigate BRI multivariate logistic regressions, restricted cubic spline models, subgroup analyses, interaction tests were used. Additionally, mediation analysis conducted to explore effect depression. Results There positive linear After controlling all covariates, individuals highest (Q4) group had an OR 1.42 (95% CI: 1.12–1.82) comparison lowest (Q1) group. Moreover, partially mediated accounting approximately 8.64% 2.04-16.00%) total effect. Conclusion positively associated playing role. provides novel perspective mechanism that connects Managing fat monitoring levels may contribute alleviating

Language: Английский

Citations

8
The challenges of assessing adiposity in a clinical setting DOI
Emma Börgeson, Saeideh Tavajoh, Stephan Lange

et al.

Nature Reviews Endocrinology, Journal Year: 2024, Volume and Issue: 20(10), P. 615 - 626

Published: July 15, 2024

Language: Английский

Citations

7
Childhood obesity: The threatening apprentice of the adiposity empire DOI Creative Commons
J. Karina Zapata, Javier Gómez‐Ambrosi, Gema Frühbeck

et al.

Reviews in Endocrine and Metabolic Disorders, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Abstract Childhood obesity is a global health problem, with its prevalence having tripled since 1975. The increase in has been predominantly developing countries, but also those high economic status. Nowadays, there are multiple definitions, however, one of the most accurate which defines as accumulation excessive body adiposity and not an weight excess. Nevertheless, mass index (BMI) frequently used tool for classification, according to cut-off points established by Center Disease Control World Health Organization tables. In children adolescents excess related appearance cardiovascular disease adulthood many comorbidities such metabolic syndrome, insulin resistance, type 2 diabetes, hypertension dysfunction-associated steatotic liver disease, among others. Currently, still controversy about ideal indicator measuring overweight obesity. BMI standardized measure may miss cases composition pathological despite within normal-weight category. An adequate knowledge impact on dysfunctional well diagnosis will allow professionals address this condition more precise comprehensive manner, substantially improve associated cardiometabolic risk prognosis.

Language: Английский

Citations

1
Revisiting the beyond BMI paradigm in excess weight diagnosis and management: A call to action DOI Creative Commons
Maite Aguas‐Ayesa, Patricia Yárnoz‐Esquíroz, Carolina M. Perdomo

et al.

European Journal of Clinical Investigation, Journal Year: 2024, Volume and Issue: 54(7)

Published: April 17, 2024

Abstract Adolphe Quételet, a 19th‐century Belgian sociologist and statistician, pioneered the incorporation of statistics into social sciences. He initiated development anthropometry since he was interested in identifying proportions ‘ideal man’. devised ratio between weight height, originally termed Quételet Index , today widely known used as body mass index or BMI. In 1835, demonstrated that normal curve accommodates distribution human traits articulating his reasoning on variance around average. Quételet's long‐lasting legacy establishment simple measure to classify people's relative an ideal for their height endures with minor variations having dramatically influenced public health agendas. While being very useful, limitations BMI are well known. Thus, revisiting beyond paradigm is necessity era precision medicine morphofunctional assessment representing way forward via composition functionality appraisal. healthcare systems were designed address acute illnesses, today's demands require radical rethinking together original reappraisal our diagnosis treatment approaches from multidimensional perspective. Embracing new methodologies advance field, gain closer look at underlying pathophysiology excess weight, keep spotlight improving diagnostic performance demonstrate its clinical validity. order provide every patient most accurate appropriate management, high degree standardization personalization needed.

Language: Английский

Citations

6
The evolution of the understanding of obesity over the last 100 years DOI
Javier Gómez‐Ambrosi, Victoria Catalán, Gema Frühbeck

et al.

International Journal of Obesity, Journal Year: 2024, Volume and Issue: 49(2), P. 168 - 176

Published: Nov. 7, 2024

Language: Английский

Citations

6
Omega-3 and Omega-6 Fatty Acids: Inverse Association with Body Fat Percentage and Obesity Risk DOI
Zhen Yang, Yuejiao Lan,

Kunpeng Yang

et al.

Nutrition Research, Journal Year: 2025, Volume and Issue: 135, P. 32 - 41

Published: Jan. 8, 2025

Language: Английский

Citations

0
Association between the lean-to-fat mass ratio and depressive symptoms in adult Peruvian population: A cross-sectional analysis DOI Creative Commons
Jamee Guerra Valencia, Akram Hernández-Vasquéz, Rodrigo Vargas‐Fernández

et al.

Journal of Affective Disorders Reports, Journal Year: 2025, Volume and Issue: unknown, P. 100868 - 100868

Published: Jan. 1, 2025

Language: Английский

Citations

0
Sex-specific associations between body composition and depression among U.S. adults: a cross-sectional study DOI Creative Commons
Yijing Li, Juan Li, Tianning Sun

et al.

Lipids in Health and Disease, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 18, 2025

Depression presents sexual dimorphism, and one important factor that increases the frequency of depression contributes to sex-specific variations in its presentation is obesity. The conventional use Body Mass Index (BMI) as an indicator obesity inherently limited due inability distinguish between fat lean mass, which limits predictive utility for risk. Implementation dual-energy X-ray absorptiometry (DXA) investigated associations body composition (fat appendicular mass) depression. Data from NHANES cycles 2011 2018 were analyzed, including 3,637 participants (1,788 males 1,849 females). Four profiles identified subjects: low adiposity-low muscle (LA-LM), adiposity-high (LA-HM), high (HA-LM) (HA-HM). After accounting confounding variables, mass index (FMI), skeletal (ASMI), percentage (BFP), phenotypes, risk assessed using restricted cubic spline (RCS) curves multivariable logistic regression models. We further conducted interaction analyses ASMI FMI females. RCS indicated a U-shaped relationship males. Logistic analysis revealed males, second (OR = 0.43, 95%CI:0.22-0.85) third 0.35, 95%CI:0.14-0.86) quartile levels significantly negatively associated with In females, BFP 1.06, 95%CI:1.03-1.09) 1.08, 95% CI:1.04-1.12) increased Additionally, compared females low-fat high-muscle phenotype, those LA-LM 3.97, 95%CI:2.16-7.30), HA-LM 5.40, 95%CI:2.34-12.46), HA-HM 6.36, 95%CI:3.26-12.37) phenotypes more likely develop Interestingly, interplay height-adjusted 4.67, 95%CI: 2.04-10.71). findings demonstrate how it consider when estimating depression, particularly There substantial correlation LA-LM, HA-LM, higher prevalence It advised preventative approach involves gaining losing fat.

Language: Английский

Citations

0
Adipocentric Strategy for the Treatment of Type 2 Diabetes Mellitus DOI Open Access
Juan José Gorgojo Martínez

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(3), P. 678 - 678

Published: Jan. 21, 2025

The global prevalence of obesity and type 2 diabetes mellitus (T2D) has risen in parallel over recent decades. Most individuals diagnosed with T2D exhibit adiposopathy-related (ARD), a condition characterized by hyperglycemia accompanied three core features: increased ectopic visceral fat deposition, dysregulated adipokine secretion favoring pro-inflammatory state, insulin resistance. Despite advancements precision medicine, international guidelines for continue to prioritize individualized therapeutic approaches focused on glycemic control complications, many healthcare providers predominantly maintain glucocentric strategy. This review advocates an adipocentric treatment paradigm most T2D, emphasizing the importance prioritizing weight loss reduction as key drivers intensification. By combining lifestyle modifications pharmacological agents that promote loss—including SGLT-2 inhibitors, GLP-1 receptor agonists, or dual GLP-1/GIP agonists—and, when appropriate, metabolic surgery, this approach offers potential disease remission patients shorter duration. For others, it enables superior compared traditional glucose-centered strategies while simultaneously delivering cardiovascular renal benefits. In conclusion, framework ARD, which represents majority cases, effectively integrates cardio-nephrocentric goals. constitutes optimal strategy ARD due its efficacy achieving remission, improving control, addressing obesity-related comorbidities, reducing morbidity mortality.

Language: Английский

Citations

0