Endometriosis and autoimmunity

Autoimmunity Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 103752 - 103752

Published: Jan. 1, 2025

Language: Английский

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Melatonin Alleviates Circadian Rhythm Disruption‐Induced Enhanced Luteinizing Hormone Pulse Frequency and Ovarian Dysfunction

Journal of Pineal Research, Journal Year: 2025, Volume and Issue: 77(1)

Published: Jan. 1, 2025

Circadian rhythm disruption (CRD), stemming from sleep disorders and/or shift work, is a risk factor for reproductive dysfunction. CRD has been reported to disturb nocturnal melatonin signaling, which plays crucial role in female reproduction as circadian regulator and an antioxidant. The hypothalamic-pituitary-ovarian (HPO) axis regulates reproduction, with luteinizing hormone (LH) pulse pattern playing pivotal folliculogenesis steroidogenesis. However, the effect of on HPO involvement remains unclear. Female CBA/CaJ mice underwent modeling, involves alternating between standard light conditions 8-h advance schedule every 3 days 8 weeks, whereas control were maintained under 12:12-h light/dark (LD) cycle. Subsequent measurements diurnal levels, LH patterns assessments via serial tail-tip blood sampling evaluations ovarian function conducted. altered rhythms wheel-running activity secretion led augmented pattern, evidenced by increased frequency, mean pituitary beta-subunit (LHβ) expression, irregular estrous cycles, abnormal luteal function, endocrine oxidative stress. Melatonin treatment (10 mg/kg/day 4 weeks) significantly improved disorder mice, decreasing enhanced frequency LHβ expression. These findings further validated using vitro LβT2 cell perfusion model. Furthermore, restored scavenged reactive oxygen species, thereby preventing apoptosis preserving function. This study offers new insights into impact emphasizes potential supplementation mitigating its effects reproduction.

Language: Английский

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Live Birth After Oocyte Donation In Vitro Fertilization Cycles in Women With Endometriosis

JAMA Network Open, Journal Year: 2024, Volume and Issue: 7(1), P. e2354249 - e2354249

Published: Jan. 31, 2024

Although multiple mechanisms have been proposed to explain the infertility related endometriosis, there are no conclusive data on association of endometriosis with endometrial receptivity. The oocyte donation model in assisted reproduction technology (ART) cycles can clarify this issue.

Language: Английский

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Association between single nucleotide polymorphisms, TGF-β1 promoter methylation, and polycystic ovary syndrome

BMC Pregnancy and Childbirth, Journal Year: 2024, Volume and Issue: 24(1)

Published: Jan. 2, 2024

Abstract Background Polycystic ovarian syndrome (PCOS) is a common endocrine and metabolic disease in women. Hyperandrogenaemia (HA) insulin resistance (IR) are the basic pathophysiological characteristics of PCOS. The aetiology PCOS has not been fully identified generally believed to be related combined effects genetic, metabolic, internal, external factors. Current studies have screened for susceptibility genes large population. Here, we aimed study effect TGF-β1 methylation on clinical phenotype. Methods In this study, three generations family members with IR as main characteristic were selected research subjects. Through whole exome sequencing bioinformatic analysis, was gene family. epigenetic DNA level peripheral blood detected by heavy sulfite patients clinically characterised IR, correlation between analysed. We explored whether degree affects it participates occurrence development Results results suggest that hypomethylation CpG4 CpG7 sites promoter may involved pathogenesis affecting expression gene. Conclusions This provides new insights into

Language: Английский

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Autophagy and Female Fertility: Mechanisms, Clinical Implications, and Emerging Therapies

Cells, Journal Year: 2024, Volume and Issue: 13(16), P. 1354 - 1354

Published: Aug. 14, 2024

Autophagy, an evolutionarily conserved cellular mechanism essential for maintaining internal stability, plays a crucial function in female reproductive ability. In this review, we discuss the complex interplay between autophagy and several facets of health, encompassing pregnancy, ovarian functions, gynecologic malignancies, endometriosis, infertility. Existing research emphasizes significance embryo implantation, specifically endometrium, highlighting its necessity ensuring proper fetal development. Although some knowledge has been gained, there is still lack on specific molecular impacts quality oocytes, growth follicles, general health. Autophagy role maturation, quality, development oocytes. It also involved aging, contributing to reductions that occur with age. This review explores physiological functions system, participation toxicity, important connections endometrium embryo. addition, study investigates possibility emerging treatment approaches aim modify autophagy, using both natural substances synthetic molecules, improve fertility outcomes. Additionally, intends inspire future exploration into intricate health by reviewing recent studies pinpointing areas where current lacking. Subsequent investigations should prioritize conversion these discoveries practical uses medical field, which could potentially result groundbreaking therapies infertility other difficulties related reproduction. Therefore, gaining comprehensive understanding many effects would not only further field biology but open new possibilities diagnostic methods.

Language: Английский

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Mitochondrial Unfolded Protein Response Gene Clpp Is Required for Oocyte Function and Female Fertility

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(3), P. 1866 - 1866

Published: Feb. 3, 2024

Mitochondrial unfolded protein stress response (mtUPR) plays a critical role in regulating cellular and metabolic helps maintain homeostasis. Caseinolytic peptidase P (CLPP) is one of the key regulators mtUPR promotes degradation. Previous studies demonstrated that global deletion

Language: Английский

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The gut microbiota: emerging biomarkers and potential treatments for infertility-related diseases

Frontiers in Cellular and Infection Microbiology, Journal Year: 2024, Volume and Issue: 14

Published: Sept. 26, 2024

Infertility is a disease of impaired fertility. With socioeconomic development, changes in human lifestyles, and increased environmental pollution, the problem low fertility has become increasingly prominent. The incidence global infertility increasing every year. Many factors lead to infertility, common female include tubal factors, ovulation disorders, endometriosis, immune factors. gut microbiota involved many physiological processes, such as nutrient absorption, intestinal mucosal growth, glycolipid metabolism, system regulation. An altered flora associated with disorders polycystic ovary syndrome (PCOS), endometriosis (EMs), premature ovarian failure (POF). Dysbiosis directly or indirectly contributes development which also affect homeostasis microbiota. Identifying etiology pathogenesis patients focus reproductive medicine physicians. We studied developmental mechanism between PCOS, EMs, POF from new perspective, providing ideas for diagnosing treating diseases specific reference values eugenics.

Language: Английский

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Cardiovascular risks and endothelial dysfunction in reproductive-age women with endometriosis

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 15, 2024

Endometriosis is a prevalent gynecological condition, affecting around 10% of reproductive-age women. Inflammatory processes associated with endometriosis may contribute to endothelial dysfunction. Increased skin accumulation advanced glycation end-products (AGEs), reflecting arterial stiffness, potentially links elevated risk cardiovascular events. We hypothesized that patients have impaired function as well increased stiffness and AGE accumulation, compared healthy controls. function, levels AGEs in suffering from The study included 45 women aged 20 40: 21 24 controls, matched terms age, BMI, blood pressure values. Endo-PAT 2000 device was used for non-invasive assessment (i) expressed Reactive Hyperemia Index (RHI), (ii) Augmentation (AI) at 75 heart beats/min (AI@75). Endothelial dysfunction defined an RHI value ≤ 1.67. Reader evaluation level accumulation. Patients had lower mean values (1.69 ± 0.54 vs. 2.02 0.48, p = 0.037) higher prevalence dysfunction, (52.4% 20.8%, 0.027) Skin endometriosis, controls (2.00 0.57 1.70 0.24, 0.013). There were no significant differences AI AI@75 between the two groups. which are well-established preclinical manifestations risk. great need comprehensive assessments prevent development potential atherosclerotic-based complications.

Language: Английский

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Evaluating the association between lipidome and female reproductive diseases through comprehensive Mendelian randomization analyses

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 19, 2025

This study aimed to assess the causal relationship between lipidome and female reproductive diseases (FRDs) using an advanced series of Mendelian randomization (MR) methods. utilized genome-wide association (GWAS) summary statistics encompassing 179 lipidomes six prevalent FRDs, namely polycystic ovary syndrome (PCOS), endometriosis, uterine fibroid, infertility, endometrial cancer, ovarian cancer. The two-sample MR (TSMR) approach was employed investigate relationships, with further validation false discovery rate (FDR) multivariable (MVMR) Subsequently, a range comprehensive evaluations were performed, including sensitivity analysis, mediation reverse steiger test. Examining traits as exposures 6 FRDs outcomes, this identified significant effects 56 lipids on FRDs. Following multiple testing correction MVMR validation, sphingomyelin (d38:2) found have protective effect against PCOS (β = -0.104, 95% CI: -0.199 ~ -0.010, P 0.031). Phosphatidylcholine (18:0_22:6) associated decreased risk developing fibroid -0.111, -0.201~ -0.021, 0.016), sterol ester (27:1/20:3) showed significance in cancer -0.248, -0.443 -0.053, 0.013). Conversely, phosphatidylethanolamine (18:2_0:0) increased endometriosis 0.183, 0.015 0.350, 0.033), while (27:1/18:1) posed influence 1.007, 0.925 1.089, < 0.001), phosphatidylcholine (16:0_22:6) 0.229, 0.039 0.420, 0.018). Furthermore, it determined that associations these profiles independent BMI, obesity, diabetes, smoking, alcohol use, physical activity, inflammation, depression, waist-hip ratio, vitamin D, dehydroepiandrosterone sulphate, sex hormone binding globulin, testosterone levels. Most outcomes passed consistent tests without evidence heterogeneity, pleiotropy, or causality. results indicated close specific lipidomes, particularly sphingomyelin, lysophosphatidylethanolamine, cholesterol ester, phosphatidylcholines, These lipid species may potentially serve biomarkers future drug targets for treatment

Language: Английский

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Causal analysis of dietary preferences and the risk of endometriosis using large-scale population data

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 21, 2025

Abstract Dietary factors have recently been recognized as potentially influential in the pathogenesis of endometriosis (EM), yet studies on causal relationship between dietary preferences and EM are limited. The present study aimed to explore relationships 187 using Mendelian randomization (MR) methods. This utilised genome-wide association data from over 500,000 European participants for 64,658 patients Finland. with potential were identified two-sample MR P-values inverse variance weighted (IVW) analysis corrected false discovery rate (FDR) method ensure accuracy. Additionally, heterogeneity analysis, pleiotropy assessment, leave-one-out reverse conducted further validate solidify findings study. After FDR correction, IVW revealed that asparagus preference was significantly protective against EM, including American Society Reproductive Medicine (ASRM) stages 1–2 3–4. Conversely, different types coffee orange juice associated an increased likelihood across these stages. Subgroup indicated had a effect deep ovarian pelvic peritoneal rectovaginal septum vaginal EM. In contrast, risk fallopian tube unspecified whereas Reverse did not identify specific analysed this These suggest reduces developing may increase risk, offering new insights into management through modifications.

Language: Английский

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