Sirtuins as therapeutic targets in diabetes

Expert Opinion on Therapeutic Targets, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Introduction Sirtuins (SIRTs) are NAD+-dependent deacetylases that mediate post-translational modifications of proteins. Seven members the SIRT family have been identified in mammals. Importantly, SIRTs interact with numerous metabolic and inflammatory pathways. Thus, researchers investigated their role disorders.

Language: Английский

---

Pregnancy as a Susceptible Period to Ambient Air Pollution Exposure on the Maternal Postpartum Metabolome

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Pregnancy is a potential critical window to air pollution exposure for long-term maternal metabolic effects. However, little known about early mechanisms linking health. We included 544 pregnant Mexican women with both ambient PM2.5 levels during pregnancy and untargeted serum metabolomics examine associations between (overall monthly) postpartum metabolites, implementing FDR-adjusted robust linear regression controlling covariates. Pathway enrichment analyses (in Reactome MetaboAnalyst) effect modification by fetal sex folic acid supplementation were also evaluated. Higher throughout associated higher bile acids amino acids, dysregulated glycerophospholipids, or lower fatty acyl (FDR < 0.05), among other metabolites. Potential windows of susceptibility monthly on metabolites observed in midpregnancy 0.005). Main findings consistent strata supplementation. Metabolic pathways corresponding positive PM2.5-metabolite indicated enriched acid, dietary lipid, transmembrane transport metabolism, whereas negative associations, we identified altered involving adipogenesis, incretin peptide hormone, GLP-1, PPAR-alpha, receptors 0.05). exposures pregnancy, especially gestation, lipids as well metabolism.

Language: Английский

---

MicroRNAs as Epigenetic Biomarkers of Pathogenetic Mechanisms of the Metabolic Syndrome Induced by Antiseizure Medications: Systematic Review

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2432 - 2432

Published: April 2, 2025

Antiseizure medication (ASM) induced metabolic syndrome (AIMetS) is a common adverse drug reaction (ADR) of pharmacotherapy for epilepsy and psychiatric disorders. However, the sensitivity specificity blood biomarkers may be insufficient due to influence combined pathology, concomitant diseases, peculiarities metabolism ASMs in patients with epilepsy. Methods: The presented results experimental clinical studies microRNAs (miRs) as epigenetic MetS AIMetS, which were entered into different databases, analyzed last decade (2014-2024). Results: A systematic review demonstrated that miRs can act promising key AIMetS domains. variable role various their paralogs pathogenesis AIMetS. Therefore, part this study, an signature was proposed allows us assess risk developing severity low risk, medium high risk. Conclusions: mechanisms development are actual problem epileptology, still far from being resolved. panels (signatures) widespread ADR help increase safety circulating it necessary conduct "bridge" order replicate preclinical real practice.

Language: Английский

---

NOD1: a metabolic modulator

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 21, 2025

Nucleotide-binding oligomerization domain 1 (NOD1) is an intracellular pattern recognition receptor that detects injury signals and initiates inflammatory responses host defense. Furthermore, NOD1 serves as a metabolic mediator by influencing the metabolism of various tissues, including adipose tissue, liver, cardiovascular pancreatic β cells, adrenal glands, bones through diverse mechanisms. It has been discovered activated associated with pathological mechanisms certain diseases. This review presents comprehensive summary impact on tissue-specific metabolism.

Language: Английский

---

The role of circulating maternal batokines Slit2-C and NRG4 and circulating cord C-peptide in gestational diabetes mellitus: A case–control study

International Journal of Diabetes in Developing Countries, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 13, 2025

Language: Английский

---

Brown or beige adipose tissue – a target for metabolic health therapy?

Russian Journal for Personalized Medicine, Journal Year: 2025, Volume and Issue: 5(1), P. 6 - 28

Published: March 6, 2025

The search for new ways to solve the problem of obesity is highly relevant, since effectiveness treatment worldwide low. A possible promising target researchers brown adipose tissue. Brown tissue involved in expenditure excess energy and maintenance metabolic health, unlike white In human body, there are 2 subtypes – classic beige. This review attempts determine whether differences effects drugs on these consequences activating subtypes.

Language: Английский

---

Latest Trends on Interplay of Autophagy, Adipose Tissue, and Gut Microbiota in Obesity-Related Metabolic Disorders

Human Nutrition & Metabolism, Journal Year: 2025, Volume and Issue: unknown, P. 200313 - 200313

Published: April 1, 2025

Language: Английский

---

Targeting white adipose tissue-derived behenic acids to mitigate heart failure: Decoding the HIF1α-ATGL pathway interaction with myocardial mitochondria

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162245 - 162245

Published: April 1, 2025

Language: Английский

---

Sanhuang Xiexin Decoction ameliorates lipid disorders in obese mice via inducing browning of white adipose tissue and activating brown adipose tissue

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 11, 2025

Background Obesity has become a critical public health challenge worldwide. Prioritizing prevention and tackling root causes—rather than merely managing symptoms—is to curbing this pandemic. Strategies that activate expand brown adipose tissue beige increase energy expenditure in animal models offer therapeutic promise treat obesity. Sanhuang Xiexin Decoction (SHX) is well-known traditional Chinese medicine possesses several beneficial effects, including anti-inflammatory anti-atherosclerotic properties. This study aims investigate whether SHX can alleviate obesity by promoting the browning process tissue. Methods UPLC MS/MS was used detect constituents of extraction, as well absorbed components rat plasma. In vivo, C57BL/6J mice were fed with 60% calorie high-fat diet for 8 weeks induce 3T3-L1 white adipocyte HIB-1B cultured. Parameters body weight, food intake, Lee’s index, skin temperature, mass, blood glucose lipids detected. The histological features BAT iWAT observed H&E staining, protein expression UCP1 detected immunohistochemistry method, cells tested using immunofluorescence staining. Gene markers (e.g. Ucp1, Pgc1α, Prdm16, Cidea, Cd137, Tbx1, Tmem26), fatty acid oxidation factors Cpt-1β, Cyto-c, Fatp1) mitochondrial biogenic transcription Nrf1, Nrf2, Tfam) tissue, qRT-PCR method. Results A total 58 chemical identified UPLC-LTQ-Orbitrap-MSⁿ which provided basis basic research pharmacodynamic substances. extraction could reduce weight gain, improve lipid metabolism, enhance activity development brown-like adipocytes obese mice. Furthermore, improved gene Pgc1α Nrf1 Tfam, levels adipocytes. Conclusions Our suggested be potential candidate treatment its complications inducing activating

Language: Английский

---

Iris bungei Maxim. extract promotes brown adipocyte differentiation

Genes & Genomics, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Language: Английский

---