Hippo-vgll3 signaling may contribute to sex differences in Atlantic salmon maturation age via contrasting adipose dynamics DOI Creative Commons
Ehsan Pashay Ahi, Jukka‐Pekka Verta, Johanna Kurko

et al.

Biology of Sex Differences, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 2, 2025

Abstract Background Sexual maturation in Atlantic salmon entails a transition energy utilization, regulated by genes and environmental stimuli sex-specific manner. Males require less energy, the form of adiposity, to mature typically younger than females. Maturation age is also influenced sex-dependent fashion vgll3 genotype ( vestigial-like 3 ), co-factor Hippo pathway. The underlying molecular processes age, their interplay with adiposity genotypes, remain unclear. Methods To elucidate mechanisms sex- genotype-specific differences, we investigated association early (E) late (L) alleles transcription > 330 involved regulation pathway sexual maturation, related signals brain, adipose, gonads. Results strongest effect was observed adipose for females brain males, highlighting expression differences genotype. Genes ovarian development showed increased vgll3*EE compared vgll3*LL Moreover, males exhibited reduced markers pre-adipocyte differentiation lipolysis yet enhanced adipocyte lipid storage. Brain gene further hormones lipids, as well tight junction assembly. Conclusions Overall, these patterns point towards greater storage slower utilization males. These results suggest Hippo-dependent may be important mediators sex salmon.

Language: Английский

Hippo-vgll3 signaling may contribute to sex differences in Atlantic salmon maturation age via contrasting adipose dynamics DOI Creative Commons
Ehsan Pashay Ahi, Jukka‐Pekka Verta, Johanna Kurko

et al.

Biology of Sex Differences, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 2, 2025

Abstract Background Sexual maturation in Atlantic salmon entails a transition energy utilization, regulated by genes and environmental stimuli sex-specific manner. Males require less energy, the form of adiposity, to mature typically younger than females. Maturation age is also influenced sex-dependent fashion vgll3 genotype ( vestigial-like 3 ), co-factor Hippo pathway. The underlying molecular processes age, their interplay with adiposity genotypes, remain unclear. Methods To elucidate mechanisms sex- genotype-specific differences, we investigated association early (E) late (L) alleles transcription > 330 involved regulation pathway sexual maturation, related signals brain, adipose, gonads. Results strongest effect was observed adipose for females brain males, highlighting expression differences genotype. Genes ovarian development showed increased vgll3*EE compared vgll3*LL Moreover, males exhibited reduced markers pre-adipocyte differentiation lipolysis yet enhanced adipocyte lipid storage. Brain gene further hormones lipids, as well tight junction assembly. Conclusions Overall, these patterns point towards greater storage slower utilization males. These results suggest Hippo-dependent may be important mediators sex salmon.

Language: Английский

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