One-Pot Three Component Synthesis of Quinazolin-4(3H)-One Derivatives: Investigation of Photophysical Properties and FRET Application toward Protein Lysozyme DOI
Soumen Sarkar,

Subhro Mandal,

Animesh Pramanik

et al.

Polycyclic aromatic compounds, Journal Year: 2023, Volume and Issue: 44(3), P. 1896 - 1917

Published: May 12, 2023

AbstractAbstractA one-pot, three-component reaction between isatoic anhydride, 1,3-diketones, and amines/arylhydrazines catalyzed by a combination of molecular I2 Et3N in open-air affords series quinazolin-4(3H)-one derivatives good yield. The protocol offers an operationally simple, facile, cost-effective pathway utilizing easily accessible reagents under mild conditions with significant substrate scope. results steady state time-resolved absorption emission spectroscopy indicate the potential as fluorescence probe. They exhibit unique photophysical responses different solvent environments. In addition, they can also act FRET acceptors during interaction protein lysozyme. Preliminary biological studies that quinazolin-4(3H)-ones are cell permeable be used fluorescent probe for bio-imaging human cervical cancer (HeLa) cells.Keywords: One-pot synthesisquinazolin-4(3H)-onesI2/Et3N combo-catalystfluorescenceFRETmolecular dockingcell imaging Disclosure statementNo conflict interest was reported author(s).Author contributionsThe manuscript written through contributions all authors. All authors have approved final version manuscript.Additional informationFundingS.S acknowledges UGC Dr. D. S. Kothari postdoctoral fellowship. S.M. thanks UGC, New Delhi, India Senior Research Fellowship (SRF). grateful to Prof. C. Bhattacharya, Department Chemistry, Jadavpur University K. Chattopadhyay, IICB, providing instrumental facilities studies. We thankful Chall Chowdhury, IICB Maiti, their help interpretation docking. Crystallography performed at DST-FIST, India-funded single crystal X-ray diffractometer facility Calcutta. financial assistance Centre Advanced Study (CAS-V, Delhi) Calcutta gratefully acknowledged.

Language: Английский

One-Pot Three Component Synthesis of Quinazolin-4(3H)-One Derivatives: Investigation of Photophysical Properties and FRET Application toward Protein Lysozyme DOI
Soumen Sarkar,

Subhro Mandal,

Animesh Pramanik

et al.

Polycyclic aromatic compounds, Journal Year: 2023, Volume and Issue: 44(3), P. 1896 - 1917

Published: May 12, 2023

AbstractAbstractA one-pot, three-component reaction between isatoic anhydride, 1,3-diketones, and amines/arylhydrazines catalyzed by a combination of molecular I2 Et3N in open-air affords series quinazolin-4(3H)-one derivatives good yield. The protocol offers an operationally simple, facile, cost-effective pathway utilizing easily accessible reagents under mild conditions with significant substrate scope. results steady state time-resolved absorption emission spectroscopy indicate the potential as fluorescence probe. They exhibit unique photophysical responses different solvent environments. In addition, they can also act FRET acceptors during interaction protein lysozyme. Preliminary biological studies that quinazolin-4(3H)-ones are cell permeable be used fluorescent probe for bio-imaging human cervical cancer (HeLa) cells.Keywords: One-pot synthesisquinazolin-4(3H)-onesI2/Et3N combo-catalystfluorescenceFRETmolecular dockingcell imaging Disclosure statementNo conflict interest was reported author(s).Author contributionsThe manuscript written through contributions all authors. All authors have approved final version manuscript.Additional informationFundingS.S acknowledges UGC Dr. D. S. Kothari postdoctoral fellowship. S.M. thanks UGC, New Delhi, India Senior Research Fellowship (SRF). grateful to Prof. C. Bhattacharya, Department Chemistry, Jadavpur University K. Chattopadhyay, IICB, providing instrumental facilities studies. We thankful Chall Chowdhury, IICB Maiti, their help interpretation docking. Crystallography performed at DST-FIST, India-funded single crystal X-ray diffractometer facility Calcutta. financial assistance Centre Advanced Study (CAS-V, Delhi) Calcutta gratefully acknowledged.

Language: Английский

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