An Efficient One Pot Synthesis and Biological Activities of 6H-Indolo[2,3-b]quinoxalines Promoted by Palladium Acetate as Catalyst DOI Open Access

B. V. Durgarao,

D. Sirisha,

Karri Apparao

et al.

Asian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 36(9), P. 2001 - 2005

Published: Aug. 30, 2024

A multi-component one pot protocol for the synthesis of quinoxalines derivatives by condensation reaction substituted isatin with o-phenylene diamine in presence palladium acetate as catalyst strong base such triphenylphosphine under conventional method has been reported. The molecular structures newly synthesized compounds were characterized elemental analyses, IR, 1H NMR, 13C NMR and LCMS spectral data. presented is mild, inexpensive, highly atom economy easy work up to give products good excellent yields. All also evaluated vitro antibacterial assay against Gram-negative (Escherichia coli Staphylococcus aureus), Gram-positive (Salmonella typhi Bacillus subtilis) fungi (Aspergillus niger Candida albicans) pathogenic bacteria comparison standards streptomycin fluconazole.

Language: Английский

Recent Methods for the Synthesis of Quinoxaline Derivatives and their Biological Activities DOI
Thoraya A. Farghaly,

Raghad M. Alqurashi,

Ghada S. Masaret

et al.

Mini-Reviews in Medicinal Chemistry, Journal Year: 2023, Volume and Issue: 24(9), P. 920 - 982

Published: Oct. 27, 2023

Abstract: Quinoxaline derivatives have been incorporated into numerous marketed drugs used for the treatment of various diseases. Examples include glecaprevir (Mavyret), voxilaprevir (Vosevi), Balversa (L01EX16) (erdafitinib), carbadox, XK469R (NSC698215), and becampanel (AMP397). These quinoxaline exhibit a diverse range pharmacological activities, including antibacterial, antitubercular, antiviral, anti-HIV, anti-inflammatory, antifungal, anticancer, antiproliferative, antitumor, kinase inhibition, antimicrobial, antioxidant, analgesic effects. Recognizing significance these bioactive derivatives, researchers dedicated their efforts to developing synthetic methods production. This review aimed compile most recent findings on synthesis biological properties from 2015 2023.

Language: Английский

Citations

9
An Efficient One Pot Synthesis and Biological Activities of 6H-Indolo[2,3-b]quinoxalines Promoted by Palladium Acetate as Catalyst DOI Open Access

B. V. Durgarao,

D. Sirisha,

Karri Apparao

et al.

Asian Journal of Chemistry, Journal Year: 2024, Volume and Issue: 36(9), P. 2001 - 2005

Published: Aug. 30, 2024

A multi-component one pot protocol for the synthesis of quinoxalines derivatives by condensation reaction substituted isatin with o-phenylene diamine in presence palladium acetate as catalyst strong base such triphenylphosphine under conventional method has been reported. The molecular structures newly synthesized compounds were characterized elemental analyses, IR, 1H NMR, 13C NMR and LCMS spectral data. presented is mild, inexpensive, highly atom economy easy work up to give products good excellent yields. All also evaluated vitro antibacterial assay against Gram-negative (Escherichia coli Staphylococcus aureus), Gram-positive (Salmonella typhi Bacillus subtilis) fungi (Aspergillus niger Candida albicans) pathogenic bacteria comparison standards streptomycin fluconazole.

Language: Английский

Citations

0