A Novel One-Pot Three-Component Approach to Orthoaminocarbonitrile Tetrahydronaphthalenes Using Triethylamine (Et_3N) as a Highly Efficient and Homogeneous Catalyst Under Mild Conditions and Investigating Its Anti-cancer Properties Through Molecular Docking Studies and Calculations DOI Open Access
Abdulhamid Dehghani,

Yousef Delshad,

Moslem Ahmadpour

et al.

Qeios, Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

An efficient and environmentally friendly method for the one-pot synthesis of ortho-aminocarbonitrile tetrahydronaphthalenes has been developed in presence triethylamine (Et3N) as a homogeneous catalyst. The multicomponent reactions benzaldehydes, cyclohexanone malononitrile were carried out under mild conditions to obtain some tetrahydronaphthalene derivatives. A broad range structurally diverse benzaldehydes applied successfully, corresponding products (4A-L) obtained good excellent yields (87-98%) very short times (10-25 minutes). present approach provides several advantages including simple workup, high yields, reaction conditions, times, little catalyst loading not requiring specialized equipment. Furthermore, with help computational chemistry drug design methods, anti-cancer properties these compounds studied investigated. All synthesized bind an agonist at active site 3A8P protein, which leads inactivation this protein produces beneficial effects during cancer treatment. In compounds, ligands establish hydrogen bonds leucine A:728 residues through nitrogen, special vital role biological sciences pharmaceutical connections. study, it was found that have potential become oral drug.

Language: Английский

Tetramethylguanidine-Functionalized Novel and Recyclable Nanocatalyst for the Synthesis of Pyrazolophthalazinediones DOI

Zahra Mirzaei,

Manouchehr Mamaghani,

M. A. Mehrdad

et al.

Polycyclic aromatic compounds, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 21

Published: March 17, 2025

Language: Английский

Citations

0
Sensitive and highly selective nanozymatic cysteine determination over glutathione utilizing tri-nucleus Cr0.3Mn0.7Fe2O4 ferrite nanoparticles as high throughput peroxidase mimetic nanomaterials DOI

Faezeh Pourebrahim,

Mohammad Mahdi Doroodmand,

Nahid Naghshgar

et al.

Journal of the Indian Chemical Society, Journal Year: 2025, Volume and Issue: unknown, P. 101707 - 101707

Published: April 1, 2025

Language: Английский

Citations

0
Synthesis of 1, 2-Disubstituted Benzimidazoles at Ambient Temperature Catalyzed by 1-Methylimidazolium Tetraflouroborate ([Hmim] BF_4) and Investigating Their Anti-ovarian Cancer Properties Through Molecular Docking Studies and Calculations DOI Open Access
Abdulhamid Dehghani,

Yousef Delshad,

Moslem Ahmadpour

et al.

Qeios, Journal Year: 2024, Volume and Issue: unknown

Published: March 20, 2024

An environmentally benign method for the synthesis of 1, 2-disubstituted benzimidazoles by reaction aromatic aldehydes and o-phenylenediamines (OPD) in presence 1-methylimidazolium tetraflouroborate ([Hmim] BF4) at ambient temperature under green conditions is described. A broad range structurally diverse benzaldehydes were applied successfully, corresponding products obtained good to excellent yields very short times. All identified melting points, 1H 13C NMR techniques. Furthermore, with help computational chemistry drug design methods, anti-ovarian cancer properties these compounds studied investigated. synthesized bind an agonist active site 6LAD protein, which leads inactivation this protein produces beneficial effects during ovarian treatment. In study, it was found that have potential become oral anti-cancer drug.

Language: Английский

Citations

1
A Novel One-Pot Three-Component Approach to Orthoaminocarbonitrile Tetrahydronaphthalenes Using Triethylamine (Et_3N) as a Highly Efficient and Homogeneous Catalyst Under Mild Conditions and Investigating Its Anti-cancer Properties Through Molecular Docking Studies and Calculations DOI Open Access
Abdulhamid Dehghani,

Yousef Delshad,

Moslem Ahmadpour

et al.

Qeios, Journal Year: 2024, Volume and Issue: unknown

Published: July 29, 2024

An efficient and environmentally friendly method for the one-pot synthesis of ortho-aminocarbonitrile tetrahydronaphthalenes has been developed in presence triethylamine (Et3N) as a homogeneous catalyst. The multicomponent reactions benzaldehydes, cyclohexanone malononitrile were carried out under mild conditions to obtain some tetrahydronaphthalene derivatives. A broad range structurally diverse benzaldehydes applied successfully, corresponding products (4A-L) obtained good excellent yields (87-98%) very short times (10-25 minutes). present approach provides several advantages including simple workup, high yields, reaction conditions, times, little catalyst loading not requiring specialized equipment. Furthermore, with help computational chemistry drug design methods, anti-cancer properties these compounds studied investigated. All synthesized bind an agonist at active site 3A8P protein, which leads inactivation this protein produces beneficial effects during cancer treatment. In compounds, ligands establish hydrogen bonds leucine A:728 residues through nitrogen, special vital role biological sciences pharmaceutical connections. study, it was found that have potential become oral drug.

Language: Английский

Citations

0