Thiazolopyrimidine, a privileged scaffold: Recent updates on synthetic and pharmacological perspective in drug discovery
Archiv der Pharmazie,
Journal Year:
2025,
Volume and Issue:
358(3)
Published: March 1, 2025
Abstract
Heterocyclic
compounds
are
emerging
as
a
privileged
scaffold
with
plethora
of
biological
activities.
In
recent
years,
interest
in
thiazolopyrimidine
chemistry
has
significantly
increased
due
to
its
diverse
pharmacological
activities,
such
anticancer,
antimicrobial,
analgesic,
antioxidant,
anti‐inflammatory,
and
so
on.
It
provides
various
opportunities
for
structural
modifications.
The
key
intermediate
the
synthesis
fused
heterocycles
medicinal
importance.
By
considering
role
this
scaffold,
researchers
have
designed
different
synthetic
protocols
derivatives.
present
review,
several
advancements
methodology
derivatives
substitutions
been
discussed
along
activity,
which
insights
into
protocol
on
core
moiety
rational
drug
design
discovery.
Language: Английский
p‐Toluene Sulphonic Acid (PTSA): An Efficient Catalyst for One‐Pot Three‐Component Synthesis of Novel 3‐Pyrazolyl‐Thiazolidin‐4‐One Derivatives
Sharmistha Das,
No information about this author
Subhankar Paul,
No information about this author
Bijeta Mitra
No information about this author
et al.
ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(30)
Published: Aug. 6, 2024
Abstract
This
research
article
focuses
on
the
pathway
for
metal‐free
unprecedented
one‐pot
three‐component
synthesis
of
biologically
active
3‐pyrazolyl‐thiazolidin‐4‐one
derivatives
through
cyclo‐condensation
aromatic
aldehydes,
1
H
‐pyrazol‐3‐amine
and
thioglycolic
acid
in
aqueous
medium.
p
‐Toluene
sulphonic
(PTSA),
a
non‐toxic,
cheaper,
easily
accessible,
eco‐benign,
organic
acid‐catalyst
was
explored
to
mediate
this
reaction.
Formation
novel
derivatives,
environment‐benign
conditions,
quick
reaction
time,
excellent
functional
group
acceptance
moderate
high
yield
products
are
some
chief
advantages
Further,
methodology
will
surely
contribute
various
fields
synthetic
methodology,
pharmaceutical
industry
natural
bio‐active
product
synthesis.
Language: Английский