Thiazolopyrimidine, a privileged scaffold: Recent updates on synthetic and pharmacological perspective in drug discovery

Archiv der Pharmazie, Journal Year: 2025, Volume and Issue: 358(3)

Published: March 1, 2025

Abstract Heterocyclic compounds are emerging as a privileged scaffold with plethora of biological activities. In recent years, interest in thiazolopyrimidine chemistry has significantly increased due to its diverse pharmacological activities, such anticancer, antimicrobial, analgesic, antioxidant, anti‐inflammatory, and so on. It provides various opportunities for structural modifications. The key intermediate the synthesis fused heterocycles medicinal importance. By considering role this scaffold, researchers have designed different synthetic protocols derivatives. present review, several advancements methodology derivatives substitutions been discussed along activity, which insights into protocol on core moiety rational drug design discovery.

Language: Английский

p‐Toluene Sulphonic Acid (PTSA): An Efficient Catalyst for One‐Pot Three‐Component Synthesis of Novel 3‐Pyrazolyl‐Thiazolidin‐4‐One Derivatives

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(30)

Published: Aug. 6, 2024

Abstract This research article focuses on the pathway for metal‐free unprecedented one‐pot three‐component synthesis of biologically active 3‐pyrazolyl‐thiazolidin‐4‐one derivatives through cyclo‐condensation aromatic aldehydes, 1 H ‐pyrazol‐3‐amine and thioglycolic acid in aqueous medium. p ‐Toluene sulphonic (PTSA), a non‐toxic, cheaper, easily accessible, eco‐benign, organic acid‐catalyst was explored to mediate this reaction. Formation novel derivatives, environment‐benign conditions, quick reaction time, excellent functional group acceptance moderate high yield products are some chief advantages Further, methodology will surely contribute various fields synthetic methodology, pharmaceutical industry natural bio‐active product synthesis.

Language: Английский