Simple Brønsted Acid Catalyzed Three-Component Reactions for Efficient Alkylation of Indolizines with Aromatic Aldehydes and Hantzsch Esters DOI Open Access
Dong‐Dong Guo,

Jiang Geng,

Jinyi Shi

et al.

Heterocycles, Journal Year: 2023, Volume and Issue: 106(11), P. 1837 - 1837

Published: Jan. 1, 2023

An efficient three-component reaction has been developed for functionalization of indolizines with aromatic aldehydes and Hantzsch esters.Simple Brønsted acids were successfully employed as catalysts to form reactive cationic intermediate which could be efficiently trapped by ester.Different types substituted obtained good yields.Nitrogen-fused bicyclic systems such indolizine have widely investigated display various intriguing pharmacological activities depending on the decoration patterns rings diverse functional groups (Figure 1). 1 For example, antifungal, 2 antioxidant, 3 antibacterial, 4 anticancer, 5

Language: Английский

Theoretical implications on the [3 + 2] cycloaddition reactions of dibromoformaldoxime and (Z)-, (E)-3-(4-chlorobenzylidene)-1-methylindolin-2-one in terms of FMO, MEDT, and distortion-interaction theories DOI
Omid Amiri, Hormoz Khosravi,

Ayoob Bazgir

et al.

Structural Chemistry, Journal Year: 2023, Volume and Issue: 35(2), P. 615 - 626

Published: Aug. 16, 2023

Language: Английский

Citations

0
Simple Brønsted Acid Catalyzed Three-Component Reactions for Efficient Alkylation of Indolizines with Aromatic Aldehydes and Hantzsch Esters DOI Open Access
Dong‐Dong Guo,

Jiang Geng,

Jinyi Shi

et al.

Heterocycles, Journal Year: 2023, Volume and Issue: 106(11), P. 1837 - 1837

Published: Jan. 1, 2023

An efficient three-component reaction has been developed for functionalization of indolizines with aromatic aldehydes and Hantzsch esters.Simple Brønsted acids were successfully employed as catalysts to form reactive cationic intermediate which could be efficiently trapped by ester.Different types substituted obtained good yields.Nitrogen-fused bicyclic systems such indolizine have widely investigated display various intriguing pharmacological activities depending on the decoration patterns rings diverse functional groups (Figure 1). 1 For example, antifungal, 2 antioxidant, 3 antibacterial, 4 anticancer, 5

Language: Английский

Citations

0