Plasma Trimethylamine N‐Oxide Levels in Nondialysis Chronic Kidney Disease Patients Following Meal Challenge
Molecular Nutrition & Food Research,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 19, 2025
ABSTRACT
Trimethylamine
N
‐oxide
(TMAO)
is
a
uremic
toxin
accumulated
in
patients
with
chronic
kidney
disease
(CKD)
and
involved
atherosclerosis.
TMAO
derived
from
the
gut
microbiota
(nutrient
fermentation)
found
some
fish
seafood.
This
pilot
study
evaluated
acute
effects
of
cod
fish,
red
meat,
vegetable
meal
consumption
on
plasma
levels
nondialysis
CKD
patients.
Patients
(five
women,
three
men,
72.5
[7.7]
years,
body
mass
index
[BMI],
25.6
[1.4]
kg/m
2
,
glomerular
filtration
rate,
32.5
[18.5]
mL/min)
consumed
lunches
containing
codfish,
chickpeas,
within
7‐day
interval
between
meals.
were
assessed
using
HPLC‐EM/EM
method
before
after
4‐h
challenge.
presented
9.06
µM.
Consumption
codfish
significantly
increases
(to
23.5
µM,
p
<
0.001)
compared
to
meat
chickpeas.
We
conclude
that
meal,
provoked
transient
elevation
CKD.
Therefore,
this
result
suggests
it
prudent
prescribe
low
content
for
these
The
response
ingesting
TMAO‐rich
foods
needs
more
study.
Language: Английский
Gut Dysbiosis and Its Role in the Anemia of Chronic Kidney Disease
Toxins,
Journal Year:
2024,
Volume and Issue:
16(11), P. 495 - 495
Published: Nov. 17, 2024
The
gut
dysbiosis
present
in
chronic
kidney
disease
(CKD)
has
been
associated
with
anemia.
Factors
such
as
the
accumulation
of
gut-derived
uremic
toxins,
increased
barrier
permeability-induced
inflammation,
and
a
reduced
intestinal
production
short-chain
fatty
acids
(SCFAs),
all
changes
microbiota
composition
CKD,
may
lead
to
development
or
worsening
anemia
renal
patients.
Understanding
addressing
these
mechanisms
related
CKD
patients
can
help
delay
improve
its
control
this
population.
One
approach
is
avoid
reduce
use
drugs
linked
phosphate
binders,
oral
iron
supplementation,
antibiotics,
others,
unless
they
are
indispensable.
Another
involves
introducing
dietary
that
promote
healthier
and/or
using
prebiotics,
probiotics,
symbiotics
setting.
These
measures
increase
presence
SCFA-producing
saccharolytic
bacteria
proteolytic
bacteria,
thereby
lowering
toxins
inflammation.
By
ameliorating
CKD-related
dysbiosis,
strategies
also
enhance
response
erythropoiesis-stimulating
agents
(ESAs)
ESA-resistant
In
review,
we
have
explored
relationship
between
propose
feasible
solutions,
both
those
already
known
potential
future
treatments.
Language: Английский