Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(12), P. 1157 - 1157
Published: Dec. 19, 2024
Chronic kidney disease (CKD) is a major worldwide health concern because of its progressive nature and complex biology. Traditional diagnostic therapeutic approaches usually fail to account for heterogeneity, resulting in low efficacy. Precision medicine offers novel approach studying by combining omics technologies such as genomics, transcriptomics, proteomics, metabolomics, epigenomics. By identifying discrete subtypes, molecular biomarkers, targets, these pave the way personalized treatment approaches. Multi-omics integration has enhanced our understanding CKD revealing intricate linkages pathways that contribute resistance progression. While pharmacogenomics insights into expected responses treatments, single-cell spatial transcriptomics can be utilized investigate biological heterogeneity. Despite significant development, challenges persist, including data concerns, high costs, ethical quandaries. Standardized protocols, collaborative data-sharing frameworks, advanced computational tools machine learning causal inference models are required address challenges. With advancement technology, nephrology may benefit from improved accuracy, risk assessment, care. overcoming barriers, precision potential develop techniques improving patient outcomes treatment.
Language: Английский