A Glyphosate-based herbicide Induces effects in the early life stages of Nile tilapia (Oreochromis niloticus)

The Egyptian Journal of Aquatic Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 1, 2025

Language: Английский

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Effects of Glyphosate on Zebrafish (Danio rerio) Developmental Toxicity

Environmental Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: April 2, 2025

Glyphosate has been widely used in agricultural production as a highly effective, low-toxic, broad-spectrum organophosphorus herbicide. However, there controversy about whether it is toxic to the nervous system. In order explore this issue depth, present study analyzed molecular mechanism of action glyphosate from four perspectives, namely, gene regulation, protein expression, morphological changes, and behavioral assessed potential effects on development system zebrafish through establishment model. The results showed that embryos at 6 hpf after fertilization were exposed until 72 120 hpf. After exposure, was found central development-related Elavl3 down-regulated, GAP-43, Neurog1, GFAP up-regulated. expression HuC protein, which maintain neuronal axonal homeostasis, significantly reduced, repair neurological damage inflammation, increased. Under regulation related genes proteins, larvae show abnormal changes during series systems such heart rate slowing, somite shortening, spinal brain malformations. At same time, zebrafish's behavior also changed, with significant decrease its total time share low-speed shift high-speed states, delayed response dark-light environmental stimuli. summary, studies have shown exposure may induce inflammation system, resulting developmental malformations, motor behavior, neurotoxicity. Therefore, possible neurotoxicity risks aquatic animals should not be ignored great concern.

Language: Английский

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Comparing the modulatory effect of fennel powder and fennel extract nanoparticles on growth, immunity and histopathological changes of Nile tilapia

Aquaculture, Journal Year: 2025, Volume and Issue: unknown, P. 742566 - 742566

Published: April 1, 2025

Language: Английский

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Single and joint toxicity of ethoprophos and bispyribac-sodium to Oreochromis niloticus: biochemical and genotoxic responses

Fish Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: 51(3)

Published: April 23, 2025

Language: Английский

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Hormonal and histopathological alterations in Nile tilapia, Oreochromis niloticus exposed to sublethal concentrations of ammonia

Comparative Clinical Pathology, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

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Efficacy of dietary Ceratonia silique and Zingiber offcinale on the immune-antioxidant-signaling pathways, growth, physiological response, and ammonia resistance in Oreochromis niloticus reared under unchanged water

Fish Physiology and Biochemistry, Journal Year: 2025, Volume and Issue: 51(3)

Published: May 22, 2025

Abstract Prioritizing water management and maintaining its quality for as long possible, while lowering related stressors, are crucial sustainable aquaculture. To achieve this equilibrium, enriched aquafeed with natural immunostimulants is essential to success. In trend, 6 weeks feeding trial was conducted evaluate the effects of Ceratonia siliqua syrup (CSS) Zingiber officinale powder (ZOP) in Nile tilapia ( Oreochromis niloticus ) reared under a zero-water exchange. The immune-antioxidant, growth, physiological responses, antioxidant/inflammatory pathways-associated genes well ammonia tolerance were evaluated. Fish (weighing 25.85 ± 1.42 g) randomly housed into six groups n = 30 fish/group; ten fish/replicate; three replicates/group). control group fed basal diet without any additives. second (CSS1.25) supplemented 1.25% CSS. third (ZOP0.5) fourth (ZOP1) diets 0.5 1% ZOP. fifth (CSS1.25 + ZOP0.5) sixth ZOP1) CSS or All treatments kept exchange weeks. Findings revealed most notable improvement P < 0.05) growth rate (final body weight specific rate) survival fish dietary ZOP CSS1.25 ZOP0.5 diets. Hepato-renal markers (alanine aspartate aminotransferases, urea, glucose, cortisol) lipid peroxides (malonaldehyde) declined by and/or Immuno-antioxidants (immunoglobulin M, lysozyme, superoxide dismutase (SOD), reduced glutathione) significantly boosted ZOP1 groups. addition, markedly upregulated antioxidant-linked SOD glutathione peroxidase) downregulated stress gene (heat shock protein 70) pro-inflammatory cytokines (interleukin-1β tumor necrosis factor-alpha). decreased mortality during stress. reported having best outcomes throughout measured indices. Overall, our findings demonstrate that at optimum doses can improve immune response, functions O. stressful conditions (unchanged water) aquaculture industry.

Language: Английский

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Genotoxic activity of glyphosate and co-formulants in glyphosate-based herbicides assessed by the micronucleus test in human mononuclear white blood cells

Toxicology Reports, Journal Year: 2025, Volume and Issue: unknown, P. 102063 - 102063

Published: June 1, 2025

Language: Английский

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Chronic exposure to glyphosate induces cardiac remodeling without functional damage and promotes hepatic morphological and biochemical alterations in rats

Life Sciences, Journal Year: 2025, Volume and Issue: 377, P. 123801 - 123801

Published: June 4, 2025

Language: Английский

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Glyphosate and aminomethylphosphonic acid impact on redox status and biotransformation in fish and the mitigating effects of diet supplementation

Veterinary Research Communications, Journal Year: 2024, Volume and Issue: 48(5), P. 2901 - 2914

Published: July 29, 2024

Language: Английский

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Promoting Growth and Health of African Catfish, Clarias gariepinus, Through Dietary Novel Supplement, Ginger, Zingiber officinale Rosc, Leaf Powder

Aquaculture Studies, Journal Year: 2023, Volume and Issue: 24(4)

Published: Dec. 20, 2023

African catfish is a popular freshwater aquaculture species as it can be farmed at high stocking density. However, density caused growth and health impairment. Hence, nutritional approach such feed additive applied in fish farming to overcome this issue. This study evaluated the impacts of ginger (Zingiber officinale) leaf powder (GLP) on performance, digestive enzymes activities, antioxidative response, disease resistance towards Edwardsiella tarda infection catfish. A feeding trial was performed using control diet four formulated diets with GLP 1, 2, 3, 4%. Ginger an herb used cuisine traditional medicine. It reported possesses medicinal values antimicrobial, anti-oxidant, immune system modulator. After eight weeks, performance GLP-treated significantly improved than control, best results were observed 2 3% groups (p<0.05). Meanwhile, supplemented 1 4% demonstrated comparable performance. There significant decreasing trend FCR, HSI, VI, where lowest recorded by groups, followed 1% GLP, The activity, including amylase, lipase, protease, higher dietary highest activity exhibited (p<0.05), groups. increasing had catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD) activities fed Furthermore, cumulative survival rate In summary, revealed that potentially enhanced production recommended doses 3%.

Language: Английский

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