N-acetylcysteine and chitosan conjugate modified dexamethasone nanostructured lipid carriers: Enhanced permeability, precorneal retention and lower inflammation for the treatment of dry eye syndrome

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: 299, P. 140123 - 140123

Published: Jan. 20, 2025

Language: Английский

Enhanced Tear Film Concentrations of Cefazolin and Chloramphenicol Using Cross‐Linked Hyaluronic Acid in Canine Eyes

Veterinary Ophthalmology, Journal Year: 2025, Volume and Issue: unknown

Published: March 16, 2025

ABSTRACT Objective To evaluate the impact of two excipients, 1.4% polyvinyl alcohol (PVA) and 0.75% cross‐linked hyaluronic acid (XHA), on tear film concentrations cefazolin chloramphenicol. Animals Studied Ten ophthalmologically healthy dogs. Procedures Cefazolin chloramphenicol were compounded into 5.5% 0.5% solutions, respectively, using either PVA or XHA. In first trial, each dog received cefazolin‐PVA in one randomly assigned eye cefazolin‐XHA contralateral eye. One month later, experiment was repeated formulations. Tear fluid sampled at 0, 1, 5, 10, 15, 30, 60, 120, 240, 360, 480 min following eyedrop administration 2 μL capillary tubes. measured UV–Vis spectrophotometry. Results significantly higher with XHA compared to all time points ( p ≤ 0.020), except for baseline (both antibiotics), times 1 min, 60 120 cefazolin. The kinetics exhibited a biphasic pattern, drug levels decreasing from 0 then slightly increasing between 360 before declining again until min. area under time‐concentration curve (AUC 0−480 ) greater versus formulations = 0.002), median 2.4 4.2 chloramphenicol, respectively. Conclusion enhanced retention overall exposure both canine film. These findings suggest that could serve as superior delivery vehicle ocular antibiotics, potentially improving treatment outcomes ophthalmic infections.

Language: Английский

Biogenic Amino Acid Cross-Linked Hyaluronic Acid Nanoparticles Containing Dexamethasone for the Treatment of Dry Eye Syndrome

AAPS PharmSciTech, Journal Year: 2025, Volume and Issue: 26(4)

Published: March 27, 2025

Language: Английский