Fumonisin B1 Exposure Causes Intestinal Tissue Damage by Triggering Oxidative Stress Pathways and Inducing Associated CYP Isoenzymes DOI Creative Commons
Changyu Cao, Hua Wan,

Runxi Xian

et al.

Toxins, Journal Year: 2025, Volume and Issue: 17(5), P. 239 - 239

Published: May 12, 2025

Fumonisin B1 (FB1) is considered the most toxic fumonisin produced by fungi and commonly found in contaminated feed crops. its metabolites extensively exist crops, where FB1-polluted crop ingestion can do harm to livestock poultry, causing poultry intestinal toxicity latter. For investigating FB1-mediated toxicity, we assessed function of FB1 exposure quail intestines explored possible molecular mechanisms. In total, 120 pups were classified into two groups, those control group given a typical diet, experimental diet that contained 30 mg/kg FB1. We evaluated histopathological ultrastructural changes quails’ on days 14, 28, 42, studied mechanisms assessing oxidative stress, inflammation, nuclear xenobiotic receptors (NXRs). Our results suggest causes inflammation triggering stress pathways modulating NXRs induce Cytochrome P450 proteins (CYP) isoforms, leading damage. The this study shed novel light mechanism underlying FB1-induced injury juvenile quails.

Language: Английский

Fumonisin B1 Exposure Causes Intestinal Tissue Damage by Triggering Oxidative Stress Pathways and Inducing Associated CYP Isoenzymes DOI Creative Commons
Changyu Cao, Hua Wan,

Runxi Xian

et al.

Toxins, Journal Year: 2025, Volume and Issue: 17(5), P. 239 - 239

Published: May 12, 2025

Fumonisin B1 (FB1) is considered the most toxic fumonisin produced by fungi and commonly found in contaminated feed crops. its metabolites extensively exist crops, where FB1-polluted crop ingestion can do harm to livestock poultry, causing poultry intestinal toxicity latter. For investigating FB1-mediated toxicity, we assessed function of FB1 exposure quail intestines explored possible molecular mechanisms. In total, 120 pups were classified into two groups, those control group given a typical diet, experimental diet that contained 30 mg/kg FB1. We evaluated histopathological ultrastructural changes quails’ on days 14, 28, 42, studied mechanisms assessing oxidative stress, inflammation, nuclear xenobiotic receptors (NXRs). Our results suggest causes inflammation triggering stress pathways modulating NXRs induce Cytochrome P450 proteins (CYP) isoforms, leading damage. The this study shed novel light mechanism underlying FB1-induced injury juvenile quails.

Language: Английский

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