Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Oct. 5, 2024
Abstract Micropollutants, such as heavy metals and pesticides, inhibit microbial growth, threatening ecosystems. Yet, the mechanism behind mycoremediation of pesticide lindane multiple (Cd, Total Cr, Cu, Ni, Pb, Zn) remains poorly understood. In our study, we investigated cellular responses in Aspergillus fumigatus PD-18 using LC-MS/MS, identifying 2190 proteins, 1147 which were consistently present under both stress conditions. Specifically, Cu-Zn superoxide dismutase heat shock proteins up-regulated to counter oxidative protein misfolding. Proteins involved intracellular trafficking, secretion, vesicular transport; RNA processing modification showed enhanced abundance regulating response pathways. Additionally, haloalkane dehalogenase homogentisate 1,2-dioxygenase played pivotal roles mineralization. Bioinformatics analysis highlighted enriched pathways Glyoxylate dicarboxylate metabolism Purine metabolism, that are crucial for combating adverse environments. We identified hub 26 S proteasome regulatory subunit complex potential biomarker remedial targets wastewater, suggesting practical applications environmental remediation.
Language: Английский
Citations
1Chemical Constituents and Bioactivities of the Plant-Derived Fungus Aspergillus fumigatus
Molecules, Journal Year: 2024, Volume and Issue: 29(3), P. 649 - 649
Published: Jan. 30, 2024
A new bergamotane sesquiterpenoid, named xylariterpenoid H (1), along with fourteen known compounds (2–15), were isolated from the crude extract of Aspergillus fumigatus, an endophytic fungus Delphinium grandiflorum L. Their structures elucidated mainly by extensive analyses NMR and MS spectroscopic data. In addition, screening results antibacterial cytotoxic activities 1–15 showed that compound 4 displayed against Staphylococcus aureus MRSA (methicillin-resistant S. aureus) MIC value 3.12 µg/mL.
Language: Английский
Citations
0Genomic and morphological characterization of Knufia obscura isolated from the Mars 2020 spacecraft assembly facility
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: May 28, 2024
Abstract Members of the family Trichomeriaceae, belonging to Chaetothyriales order and Ascomycota phylum, are known for their capability inhabit hostile environments characterized by extreme temperatures, oligotrophic conditions, drought, or presence toxic compounds. The genus Knufia encompasses many polyextremophilic species. In this report, genomic morphological features strain FJI-L2-BK-P2 presented, which was isolated from Mars 2020 mission spacecraft assembly facility located at Jet Propulsion Laboratory in Pasadena, California. identification is based on sequence alignment marker genes, multi-locus analysis, whole genome phylogeny. were studied using a diverse range microscopic techniques (bright field, phase contrast, differential interference contrast scanning electron microscopy). phylogenetic genes exhibited highest similarities with type obscura (CBS 148926 T ) that gas tank car Italy. To validate species identity, genomes both strains (FJI-L2-BK-P2 CBS sequenced, annotated, confirmed as K. obscura. analysis description characteristics may contribute refining taxonomy Key reported strain, resembling microsclerotia chlamydospore-like propagules. These be characteristic black fungi could potentially facilitate adaptation harsh environments.
Language: Английский
Citations
0Microbial transformation of argentatins by Cunninghamella elegans
Biocatalysis and Biotransformation, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 9
Published: July 31, 2024
Microbial biotransformation of argentatin A (1), isoargentatin (2) and B (3), the cycloartane- lanostane-type triterpenoid constituents guayule (Parthenium argentatum) resin, with Cunninghamella elegans ATCC 9245-A0 afforded eight new metabolites 4–11. These were identified as products formed a result of: (i) α- β-hydroxylation at C-7 C-11; (ii) sequential oxidation these newly alcohols to their corresponding carbonyl analogues; (iii) rearrangement 9(10)-cyclopropane ring. The observed regiospecific hydroxylation reactions are possibly catalyzed by cytochrome P450 enzymes known be produced C. elegans. It is interesting that among 9–11 (3) group C-11, only 11 had resulted from ring under conditions used for biotransformation. This constitutes first report argentatins
Language: Английский
Citations
0Biodegradation of Industrial Pollutants Using Fungi
Published: Jan. 1, 2024
Language: Английский
Citations
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