A review on comparative analysis of marine and freshwater fish gut microbiomes: insights into environmental impact on gut microbiota DOI Creative Commons
Bhanu Pratap Singh, Kushal Thakur, Hishani Kumari

et al.

FEMS Microbiology Ecology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Abstract The gut microbiota, which includes prokaryotes, archaea, and eukaryotes like yeasts, some protozoa, fungi, significantly impact fish by affecting digestion, metabolism, the immune system. In this research, we combine various tasks carried out bacteria in of fish. This study also examines microbiome composition marine freshwater fish, identifying important bacterial species linked to different biological functions. diversity within highlights importance considering nutrition, habitat, environmental factors microbiological research on ever-changing indicates that microbial communities are specifically adapted meet needs both host its environment. can adjust a specific environment with help microbiota. is crucial for comprehending complex relationships between their aquatic environments. These discoveries have implications aquaculture practices, fisheries administration, broader ecological processes With further progress area study, knowledge acquired would offer valuable standpoint enhance our comprehension microbiology sustainability nutrition resources.

Language: Английский

Modulating butyric acid-producing bacterial community abundance and structure in the intestine of immunocompromised mice with neutral polysaccharides extracted from Codonopsis pilosula DOI
XinQian Rong, Qinglong Shu

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 278, P. 134959 - 134959

Published: Aug. 22, 2024

Language: Английский

Citations

10
Characteristics and Clinical Significance of Gut Microbiota in Patients With Epstein‐Barr Virus‐Associated Liver Dysfunction DOI
Zhan Yi, Yu Fu, Hanchuan Dai

et al.

Microbiology and Immunology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

ABSTRACT Infectious mononucleosis (IM) is mainly triggered by Epstein‐Barr virus (EBV) infection. There are few studies on the role of gut microbiota in IM and EBV‐associated liver dysfunction. The aim this study was to investigate characteristics dysfunction evaluate relationship between severity dysbiosis cytokine levels. A case‐control performed. Individuals meeting inclusion exclusion criteria for EBV‐induced were enrolled their fecal blood samples collected. V3‐V4 region 16s rDNA gene sequenced; bioinformatics analysis including α ‐diversity, β linear discriminant (LDA) effect size (LEfSe) performed; correlation bacteria clinical indices analysed. total 48 participants completed tests, 18 IM, 11 dysfunction, 12 healthy children 7 EBV‐negative ‐diversity more than that IM. abundance Granulicatella , Enterococcus Atopobium Acinetobacter increased, while Prevotella Sutterella Collinsella Desulfovibrio decreased compared with correlated positively levels IL‐1 IL‐6, TNF‐ CD8 + cytotoxic T lymphocytes%. Gut significantly disturbed associated systemic immune response.

Language: Английский

Citations

1
Integrated Macrogenomics and Metabolomics Analysis of the Effect of Sea Cucumber Ovum Hydrolysates on Dextran Sodium Sulfate-Induced Colitis DOI Creative Commons

Shunmin Gong,

Liqin Sun,

Yongjun Sun

et al.

Marine Drugs, Journal Year: 2025, Volume and Issue: 23(2), P. 73 - 73

Published: Feb. 7, 2025

Inflammatory bowel disease remains a significant challenge in clinical settings. This study investigated the therapeutic potential of sea cucumber ovum hydrolysates (SCH) dextran sulfate sodium (DSS)-induced colitis mouse model. SCH, defined by its elevated stability and solubility, with molecular weight below 1000 Da, significantly alleviated DSS-induced colitis, as evidenced enhanced splenic index, reduced colonic damage, diminished serum pro-inflammatory cytokines. Furthermore, macrogenomic analysis demonstrated that SCH increased beneficial gut microbes decreased bacteria. metabolomic tissues identified levels anti-inflammatory metabolites, such Phenyllactate, 2-Hydroxyglutarate, L-Aspartic acid, mice after oral administration SCH. In conclusion, represents promising candidate for treatment colitis.

Language: Английский

Citations

0
The Effects of Dietary Resveratrol and β-Hydroxy-β-Methylbutyric Acid Supplementation at Two Protein Levels on the Ruminal Microbiome and Metabolome of Tibetan Sheep DOI Creative Commons
Kaina Zhu, Yu Zhang, Fengshuo Zhang

et al.

Agriculture, Journal Year: 2024, Volume and Issue: 14(6), P. 936 - 936

Published: June 14, 2024

Resveratrol (RES) and β-hydroxy-β-methylbutyric acid (HMB) have antioxidant, anti-inflammatory, other beneficial properties. Here, we hypothesize that supplementation with RES HMB could affect the rumen function in Tibetan sheep. This study aims to explore effects of at different protein levels on microbial metabolite compositions Four treatments (n = 30) were prepared according a 2 × factorial arrangement, two dietary (12% 14%) feed additives (RES 1.50 g/day 1.25 g/day). The experimental fed diets 12% CP level non-supplemented (L), (L-RES-HMB), 14% (H), (H-RES-HMB), respectively. Our results indicated trypsin, chymotrypsin, lipase significantly increased H-RES-HMB group (p < 0.05), while lipopolysaccharide (LPS) concentration was reduced 0.05). alpha diversity analysis found ACE indices L-RES-HMB, groups higher than L Additionally, compared L, H groups, it abundance Euryarchaeota, Spirochaeota, Metanobrevibacter group, Proteobacteria decreased A total 745 metabolites identified, which 14 common among three comparative groups. Differential mainly enriched pathways including pyrimidine metabolism, glycine, serine, threonine metabolisms, ABC transporters. Overall, RES/HMB exhibited positively interaction effect digestive enzyme activity antioxidant capacity. Dietary improved ruminal capacity through modulating community regulating metabolism.

Language: Английский

Citations

3
Enhancing immunomodulation in cyclophosphamide‐induced immunosuppressed mice through targeted modulation of butyrate‐producing gut microbiota via oral administration of astragalus polysaccharides DOI Creative Commons
XinQian Rong, Qinglong Shu

Food Science & Nutrition, Journal Year: 2024, Volume and Issue: 12(10), P. 7683 - 7695

Published: Aug. 5, 2024

Abstract Astragalus polysaccharide is one of the most extensively studied traditional Chinese medicinal polysaccharides because its immunomodulatory activity and has attracted considerable attention. Existing evidence suggests that potential mechanism related to modulation intestinal microbiota. However, current research methods on gut microbiota mainly focus 16S rRNA sequencing, providing limited specific changes in functional bacterial groups intestine. Butyrate a class short‐chain fatty acids among microbial metabolites closely associated with activity. Thus, this study, we extracted purified from astragalus composed main chain →4)‐α‐D‐Glcp‐(1 → →4,6)‐α‐D‐Glcp‐(1→, side chains →6)‐α‐D‐Glcp‐(1→ aggregated arabinose, investigated butyrate‐producing mice during immunomodulation process polysaccharide, using two bacterial‐specific primers. The results showed oral administration significantly increased butyrate production mouse intestine, restoring disrupted abundance diversity caused by immunosuppression. In conclusion, our study provides first targeted offering insights into pharmacological

Language: Английский

Citations

1
Latent tuberculosis infection is associated with an enrichment of short chain fatty acid producing bacteria in the stool of women living with HIV DOI Creative Commons
Suventha Moodley, Elouise E. Kroon, C Naidoo

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: April 2, 2024

Latent tuberculosis infection (LTBI) is common in people living with HIV (PLHIV) high TB burden settings. Active associated specific stool taxa; however, little known about the microbiota and LTBI, including PLHIV.

Language: Английский

Citations

0
Latent Tuberculosis Infection Is Associated with an Enrichment of Short-Chain Fatty Acid-Producing Bacteria in the Stool of Women Living with HIV DOI Creative Commons
Suventha Moodley, Elouise E. Kroon, C Naidoo

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(6), P. 1048 - 1048

Published: May 22, 2024

Latent tuberculosis infection (LTBI) is common in people living with HIV (PLHIV) high-TB-burden settings. Active TB associated specific stool taxa; however, little known about the microbiota and LTBI PLHIV. We characterised of PLHIV [interferon-γ release assay (IGRA)- tuberculin skin test (TST)-positive] or without (IGRA- TST-negative) (n = 25 per group). The 16S rRNA DNA sequences were analysed using QIIME2, Dirichlet-Multinomial Mixtures, DESeq2, PICRUSt2. No α- β-diversity differences occurred by status; LTBI-positive Faecalibacterium-, Blautia-, Gemmiger-, Bacteroides-enriched Moryella-, Atopobium-, Corynebacterium-, Streptococcus-depleted. Inferred metagenome data showed that LTBI-negative-enriched pathways included several metabolite degradation pathways. Stool from demonstrated differential taxa abundance based on a quantitative response to antigen stimulation. In people, older had different β-diversities than younger whereas LTBI-negative no across age groups. Amongst female PLHIV, those were, vs. LTBI, Bacteriodes-enriched, which are producers short-chain fatty acids. Taxonomic amongst according stimulation age. These enhance our understanding microbiome’s potential role LTBI.

Language: Английский

Citations

0
A review on comparative analysis of marine and freshwater fish gut microbiomes: insights into environmental impact on gut microbiota DOI Creative Commons
Bhanu Pratap Singh, Kushal Thakur, Hishani Kumari

et al.

FEMS Microbiology Ecology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Abstract The gut microbiota, which includes prokaryotes, archaea, and eukaryotes like yeasts, some protozoa, fungi, significantly impact fish by affecting digestion, metabolism, the immune system. In this research, we combine various tasks carried out bacteria in of fish. This study also examines microbiome composition marine freshwater fish, identifying important bacterial species linked to different biological functions. diversity within highlights importance considering nutrition, habitat, environmental factors microbiological research on ever-changing indicates that microbial communities are specifically adapted meet needs both host its environment. can adjust a specific environment with help microbiota. is crucial for comprehending complex relationships between their aquatic environments. These discoveries have implications aquaculture practices, fisheries administration, broader ecological processes With further progress area study, knowledge acquired would offer valuable standpoint enhance our comprehension microbiology sustainability nutrition resources.

Language: Английский

Citations

0