Food Microbiology, Journal Year: 2024, Volume and Issue: 124, P. 104621 - 104621
Published: Aug. 17, 2024
Language: Английский
Molecules, Journal Year: 2024, Volume and Issue: 30(1), P. 128 - 128
Published: Dec. 31, 2024
Multidrug-resistant (MDR) bacteria are becoming more and common, which presents a serious threat to world health could eventually render many of the antibiotics we currently use useless. The research development innovative antimicrobial tactics that can defeat these hardy infections imperative in light this predicament. Antimicrobial peptides (AMPs), have attracted lot attention due their distinct modes action capacity elude conventional resistance mechanisms, among most promising tactics. As substitute for antibiotics, AMPs varied class naturally occurring compounds target membranes disrupt cellular activities demonstrate broad-spectrum activity. objective study is present thorough summary current knowledge regarding AMP mechanisms against MDR bacteria, including immunological modulation, interactions with microbial membranes, possible synergy used drugs. In addition, define review’s scope include recent developments research, emphasizing innovations’ development, optimization, therapeutic promise. We hope emphasize crucial role will play future therapy by bringing together highlighting issues. also advocate AMPs’ continued as part comprehensive strategy counteract growing antibiotic resistance.
Language: Английский
Citations
5
Natural Product Reports, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
This review focuses on the role of microorganisms and their natural products in milk dairy products.
Language: Английский
Citations
0
Industrial Biotechnology, Journal Year: 2025, Volume and Issue: unknown
Published: April 8, 2025
Language: Английский
Citations
0
ACS Synthetic Biology, Journal Year: 2025, Volume and Issue: unknown
Published: April 16, 2025
Nonribosomal lipopeptides (NRLPs) are structurally complex natural products that play crucial ecological and biological roles. They also valuable sources lead structures for developing new pharmaceuticals. These compounds typically synthesized using a molecular assembly machinery known as nonribosomal peptide synthetases (NRPSs) or hybrid polyketide synthases-NRPSs. Unlike conventional NRPS, NRLPs characterized by starter module loads lipid chains substrate synthesis pathway supplies the necessary substrates during initiation stages. Unique critical determinants of activity NRLPs. Therefore, modifying these through combinatorial biosynthesis holds great promise unlocking their full therapeutic potential. Herein, we use term "Starter Unit" to refer initial modules lipoinitiation involved in chain process This Review provides comprehensive summary recent advances units offers insights into future directions further development.
Language: Английский
Citations
0
Critical Reviews in Biotechnology, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 17
Published: May 14, 2025
Viral outbreaks are a topic of worldwide concern, resulting in significant impact health systems, large number deaths, and huge economical losses. The damage caused by Covid-19 has further highlighted the importance prospecting for new molecules that can be applied prevention treatment viral infections. Many studies describe remarkable antimicrobial activity lipopeptides produced Bacillus spp., especially against fungi bacteria. However, research regarding antagonistic effects on viruses is less frequent. Despite that, antiviral spp. been demonstrated, indicating these could potential candidates to control diseases. In this article, compilation reports with consistent data effect mechanisms involved process presented. Moreover, immunomodulatory role toxicity profile discussed. may exert an indirect effect, since they able positively induce humoral cell-mediated immune responses. their was observed vitro vivo at nontoxic concentrations, offering safe perspective possible clinical application molecules. Finally, challenges related optimization increasing production yield addressed. This first critical review dedicated exclusively lipopeptides.
Language: Английский
Citations
0
Probiotics and Antimicrobial Proteins, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 18, 2024
Language: Английский
Citations
1
Journal of Separation Science, Journal Year: 2024, Volume and Issue: 47(19)
Published: Oct. 1, 2024
ABSTRACT Antimicrobial peptides take a specific position in the field of antibiotics (ATBs), however, from large number available molecules only few them were approved and are used clinics. These therapeutic modalities play crucial role management diseases caused by multidrug‐resistant bacterial pathogens represent last‐line therapy for infections. Therefore, there is demand rationale use such ATBs based on optimization dosing strategy to minimize risk resistance ensure sustainable efficacy drug real clinical practice. Therapeutic monitoring, as measurement concentration body fluids or tissues, results patient´s medication outcome. This beneficial could result tailored different types infection prolongation hospitals. review paper provides an actual overview antimicrobial practice covers current trends their analysis convenient advanced methodologies identification and/or quantitation biological matrices monitoring purposes. Special emphasis given methods with perspective outcomes.
Language: Английский
Citations
0
Food Microbiology, Journal Year: 2024, Volume and Issue: 124, P. 104621 - 104621
Published: Aug. 17, 2024
Language: Английский
Citations
0