
Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)
Published: Dec. 20, 2024
The nematode Caenorhabditis elegans, with its highly sensitive olfactory system, has emerged as a promising tool for testing chemotaxis. In the field of cancer diagnostics, there is growing interest in development non-invasive screening methods detection volatile organic compounds patient's urine. objective this study was to contribute existing body knowledge by evaluating ability elegans-based chemotaxis assay discriminate between urine samples from healthy individuals and patients diagnosed breast or colon cancer. Following synchronization developmental stages C. nematodes were exposed individuals. Subsequently, chemotactic indices calculated each sample. Our results demonstrated statistically significant difference response elegans compared volunteers (p < 0.001). Furthermore, test diagnostic utility, sensitivity 96%, specificity 62%, rate 73% among 100%, 72% those findings expand on previous observations, confirming remarkable hermaphrodites discriminating cancer-related samples.
Language: Английский