The chemotactic response of Caenorhabditis elegans represents a promising tool for the early detection of cancer DOI Creative Commons
Alžbeta Kaiglová, Patrícia Hockicková, Zuzana Bárdyová

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 20, 2024

The nematode Caenorhabditis elegans, with its highly sensitive olfactory system, has emerged as a promising tool for testing chemotaxis. In the field of cancer diagnostics, there is growing interest in development non-invasive screening methods detection volatile organic compounds patient's urine. objective this study was to contribute existing body knowledge by evaluating ability elegans-based chemotaxis assay discriminate between urine samples from healthy individuals and patients diagnosed breast or colon cancer. Following synchronization developmental stages C. nematodes were exposed individuals. Subsequently, chemotactic indices calculated each sample. Our results demonstrated statistically significant difference response elegans compared volunteers (p < 0.001). Furthermore, test diagnostic utility, sensitivity 96%, specificity 62%, rate 73% among 100%, 72% those findings expand on previous observations, confirming remarkable hermaphrodites discriminating cancer-related samples.

Language: Английский

Cerumenogram as an assay for the metabolic diagnosis of precancer, cancer, and cancer remission DOI Creative Commons
João Marcos G. Barbosa, Camilla Gabriela de Oliveira,

Marina Ferraz Gontijo Soares

et al.

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 22, 2025

Early diagnosis is crucial for successful cancer treatment. As a mitochondrial metabolic disease, produces volatile organic metabolites that are present in earwax, allowing differentiation between healthy individuals and those with through an assay called cerumenogram. In this case series study, we demonstrated also enables the of precancerous stages, such as hypermetabolic inflammation dysplasia, which can aid treatments to prevent progression. Additionally, reveals oncological metabolism differs from observed metaplasias, cysts, benign tumors, helping avoid unnecessary procedures due suspected malignancy. Cerumenogram be used assess remission. Thus, cerumenogram emerges might enable cancer, monitor remission, identify covering key steps tumorigenesis.

Language: Английский

Citations

0
The chemotactic response of Caenorhabditis elegans represents a promising tool for the early detection of cancer DOI Creative Commons
Alžbeta Kaiglová, Patrícia Hockicková, Zuzana Bárdyová

et al.

Discover Oncology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 20, 2024

The nematode Caenorhabditis elegans, with its highly sensitive olfactory system, has emerged as a promising tool for testing chemotaxis. In the field of cancer diagnostics, there is growing interest in development non-invasive screening methods detection volatile organic compounds patient's urine. objective this study was to contribute existing body knowledge by evaluating ability elegans-based chemotaxis assay discriminate between urine samples from healthy individuals and patients diagnosed breast or colon cancer. Following synchronization developmental stages C. nematodes were exposed individuals. Subsequently, chemotactic indices calculated each sample. Our results demonstrated statistically significant difference response elegans compared volunteers (p < 0.001). Furthermore, test diagnostic utility, sensitivity 96%, specificity 62%, rate 73% among 100%, 72% those findings expand on previous observations, confirming remarkable hermaphrodites discriminating cancer-related samples.

Language: Английский

Citations

0