Mammary gland metabolism and its relevance to the fetoplacental expression of cytokine signaling in Caveolin-1 null mice DOI

Shankar P. Poudel,

Maliha Islam, T.B. McFadden

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Abstract Mice lacking Caveolin-1 ( Cav1 ), a major protein of the lipid raft plasma membrane, show dysregulated cellular proliferation mammary gland and an abnormal fetoplacental communication during pregnancy. The aim this study is to better understand functional links metabolism with gene expression placenta fetus. Untargeted metabolomics analysis was performed examine changes in due absence . Integrative transcriptomics analyses were applied untangle metabolic pathways findings that are significantly impacted loss Genes associated specific signaling coordinated changed placenta, fetal brain -null mice. cytokine pathway emerges as key player molecular crosstalk among gland, brain. By interrogating single-nuclei data previously generated from mice, further reveals these genes differentially regulated cell types expand our understanding about role regulation mammalian

Language: Английский

Mammary gland metabolism and its relevance to the fetoplacental expression of cytokine signaling in Caveolin-1 null mice DOI

Shankar P. Poudel,

Maliha Islam, T.B. McFadden

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: April 18, 2025

Abstract Mice lacking Caveolin-1 ( Cav1 ), a major protein of the lipid raft plasma membrane, show dysregulated cellular proliferation mammary gland and an abnormal fetoplacental communication during pregnancy. The aim this study is to better understand functional links metabolism with gene expression placenta fetus. Untargeted metabolomics analysis was performed examine changes in due absence . Integrative transcriptomics analyses were applied untangle metabolic pathways findings that are significantly impacted loss Genes associated specific signaling coordinated changed placenta, fetal brain -null mice. cytokine pathway emerges as key player molecular crosstalk among gland, brain. By interrogating single-nuclei data previously generated from mice, further reveals these genes differentially regulated cell types expand our understanding about role regulation mammalian

Language: Английский

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