CNS Spectrums,
Journal Year:
2023,
Volume and Issue:
28(5), P. 581 - 586
Published: Feb. 28, 2023
Abstract
Circadian
rhythm
sleep
disorders
are
alterations
that
characterized
by
a
shift
in
the
sleep-wake
cycle
relative
to
day
and
night,
such
as
delayed
phase
disorder
(DSPD),
which
is
retard
of
at
least
2
hours
start.
Typically,
patient
falls
asleep
after
a.m.
wakes
up
10
with
symptom
onset
insomnia.
The
prevalence
DSPD
young
adults
0.48%,
increasing
3.3%
adolescents.
Interestingly,
patients
COVID-19
infection
report
anxiety
due
intensive
care
unit
lockdown
constant
exposure
bright
light.
In
addition,
post-COVID
have
an
increased
risk
developing
DSPD.
For
example,
adolescent
patients,
increases
63.3%.
Patients
also
metabolic
health,
poor
school
performance,
cognitive
impairment,
higher
other
diseases.
objective
present
review
therefore
describe
characteristics
during
pandemic
outline
its
possible
implications
for
physical
health
(eg,
metabolism)
mental
or
depression).
Molecules,
Journal Year:
2022,
Volume and Issue:
27(11), P. 3516 - 3516
Published: May 30, 2022
Neurodegenerative
diseases
(NDDs)
are
disorders
that
affect
both
the
central
and
peripheral
nervous
systems.
To
name
a
few
causes,
NDDs
can
be
caused
by
ischemia,
oxidative
endoplasmic
reticulum
(ER)
cell
stress,
inflammation,
abnormal
protein
deposition
in
neural
tissue,
autoimmune-mediated
neuron
loss,
viral
or
prion
infections.
These
conditions
include
Alzheimer's
disease
(AD),
Lewy
body
dementia
(LBD),
Parkinson's
(PD).
The
formation
of
β-sheet-rich
aggregates
intra-
extracellular
proteins
CNS
hallmarks
all
neurodegenerative
proteinopathies.
In
systemic
lupus
erythematosus
(SLE),
numerous
organs,
including
system
(CNS),
affected.
However,
inflammatory
process
is
linked
to
several
pathways
depression
because
NDDs.
Pro-inflammatory
signals
activated
aging
may
increase
vulnerability
neuropsychiatric
disorders.
Viruses
macrophages
CCR5+
T
cells
within
during
progression.
Unlike
medical
symptoms,
which
just
signs
patient's
health
as
expressed
perceived,
biomarkers
reproducible
quantitative.
Therefore,
this
current
review
will
highlight
summarize
neurological
their
biomarkers.
Biological Rhythm Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 14
Published: Jan. 10, 2025
Background/objective:
This
research
aims
to
investigate
the
circadian
rhythm
in
individuals
with
COVID-19
and
healthy
controls.
We
tested
association
between
disruptions
of
biological
rhythms
psychiatric
symptoms.
Methods/participants:
cross-sectional
study
included
a
sample
adults
Biological
were
assessed
by
Rhythms
Neuropsychiatry
Assessment
Interview
(BRIAN),
while
depression,
sleep
quality,
anxiety,
stress
levels
analyzed
using
specific
scales.
Results:
96
cases
199
controls
assessed.
Compared
controls,
showed
higher
dysfunction,
especially
sleep,
activity,
eating
behavior
domains.
Cases
stress,
depressive
symptoms,
anxiety
compared
BRIAN
scores
positively
correlated
severity
insomnia,
stress.
Conclusion:
is
associated
disturbances.
Disruptions
related
presence
International Journal of Prison Health,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 30, 2025
Purpose
This
paper
synthesises
literature
on
non-visual
effects
of
light
in
prison
environments,
drawing
attention
to
disconnect
between
research
evidence
and
current
practices.
aims
guide
designers
decision-makers
towards
lighting
strategies
that
better
support
inmates’
mental
health
rehabilitation.
Design/methodology/approach
A
focused
search
was
conducted
from
June
October
2024
using
Google
Scholar
PubMed,
targeting
peer-reviewed
studies
published
1985
2024.
Included
addressed
the
related
circadian
rhythm,
health,
artificial
natural
lighting,
stress,
aggression
hormonal
regulation.
Only
English-language
providing
empirical
or
theoretical
insights
relevant
confinement
settings
were
considered.
Studies
solely
visual
performance,
non-human
subjects
lacking
implications
excluded.
Keyword
combinations
refined
iteratively,
although
some
interdisciplinary
work
may
have
been
missed
due
indexing
terminological
variations.
Findings
Neglecting
role
design
contributes
poor
psychological
outcomes.
Limited
access
daylight
overuse
with
high
blue
content
disrupt
regulation,
worsening
sleep,
mood
health.
Conversely,
designs
maximise
exposure
use
adjustable
appropriate
spectral
qualities
can
promote
emotional
stability,
reduce
Research
limitations/implications
Relevant
still
database
limitations
variations
across
fields.
Originality/value
bridges
gap
design,
environmental
psychology
reform.
By
focusing
how
affects
rehabilitation,
it
offers
into
be
improved
foster
well-being.
Scientific Reports,
Journal Year:
2023,
Volume and Issue:
13(1)
Published: April 18, 2023
The
COVID-19
pandemic
had
negative
consequences
for
mental
health,
yet
it
is
unknown
how
and
to
what
extent
the
psychological
outcomes
of
this
stressful
event
are
moderated
by
individual
traits.
Alexithymia
a
risk
factor
psychopathology,
thus
likely
predicted
differences
in
resilience
or
vulnerability
events
during
pandemic.
This
study
explored
moderating
role
alexithymia
relationships
pandemic-related
stress
with
anxiety
levels
attentional
bias.
participants
were
103
Taiwanese
individuals
who
completed
survey
outbreak
Omicron
wave.
Additionally,
an
emotional
Stroop
task
including
neutral
stimuli
was
used
measure
Our
results
demonstrate
that
lesser
impact
on
higher
level
alexithymia.
Moreover,
we
found
exposure
stressors,
indicated
less
bias
toward
COVID-19-related
information.
Thus,
plausible
tended
avoid
information,
which
could
temporarily
relieve
stressors
动物学研究,
Journal Year:
2022,
Volume and Issue:
43(6), P. 1041 - 1062
Published: Jan. 1, 2022
Infection
with
severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
causes
diverse
clinical
manifestations
and
tissue
injuries
in
multiple
organs.
However,
cellular
molecular
understanding
of
SARS-CoV-2
infection-associated
pathology
immune
defense
features
different
organs
remains
incomplete.
Here,
we
profiled
approximately
77
000
single-nucleus
transcriptomes
the
lung,
liver,
kidney,
cerebral
cortex
rhesus
macaques
(
Macaca
mulatta)
infected
healthy
controls.
Integrated
analysis
multi-organ
dataset
suggested
that
liver
harbored
strongest
global
transcriptional
alterations.
We
observed
prominent
impairment
lung
epithelial
cells,
especially
AT2
ciliated
evident
signs
fibrosis
fibroblasts.
These
injury
characteristics
are
similar
to
those
reported
patients
disease
2019
(COVID-19).
Furthermore,
found
suppressed
MHC
class
I/II
activity
inflammatory
response
activation
kynurenine
pathway,
which
induced
development
an
immunosuppressive
microenvironment.
Analysis
kidney
highlighted
tropism
tubule
cells
SARS-CoV-2,
membranous
nephropathy
(an
autoimmune
disease)
caused
by
podocyte
dysregulation.
In
addition,
identified
pathological
states
astrocytes
oligodendrocytes
cortex,
providing
insights
into
COVID-19-related
neurological
implications.
Overall,
our
transcriptomic
survey
SARS-CoV-2-infected
broadens
antiviral
defects
infection,
may
facilitate
therapeutic
interventions
for
COVID-19.新型冠状病毒（SARS-CoV-2）感染可以造成多种临床表现和多种器官的组织损伤。但是对于新冠病毒感染相关的病理和免疫防御特征的细胞和分子水平的理解还不完善。该研究中，我们对感染新冠病毒的猕猴及健康对照个体的肺脏、肝脏、肾脏、大脑皮层进行单细胞核转录组测序和分析，共获得了约77
000个单细胞核的转录组数据。多器官数据集整合分析结果表明肝脏具有最强的全局转录改变。我们发现肺脏中的上皮细胞，尤其是AT2细胞和纤毛细胞，存在突出的损伤特征，在成纤维细胞中纤维化迹象明显。肺部的这些损伤特征与新冠肺炎（COVID-19）病人中报道的结果很相似。此外，我们发现肺中的主要组织相容性复合体（MHC）I/II类分子活性下调，肝脏中存在炎症反应和犬尿氨酸通路的激活，它会诱导免疫抑制性微环境的发展。对肾脏数据集的分析发现肾小管上皮细胞对新冠病毒具有更强的趋向性，同时发现了感染猕猴出现了由足细胞失调引起的膜性肾病(一种自身免疫疾病)。另外，我们还识别到了大脑皮层中星形胶质细胞和少突胶质细胞的病理状态，为新冠肺炎相关的神经学影响提供了分子洞察。总之，此项对新冠病毒感染的猕猴模型多器官进行单细胞核转录组研究的工作拓宽了我们对新冠病毒感染造成的疾病特征和机体抗病毒免疫缺陷的理解，这可能促进新冠肺炎治疗干预手段的开发。.
