Long-term exposure to di(2-ethylhexyl) phthalate, diisononyl phthalate, and a mixture of phthalates alters estrous cyclicity and/or impairs gestational index and birth rate in mice

Toxicological Sciences, Journal Year: 2023, Volume and Issue: 193(1), P. 48 - 61

Published: March 17, 2023

Abstract Phthalates are found in plastic food containers, medical plastics, and personal care products. However, the effects of long-term phthalate exposure on female reproduction unknown. Thus, this study investigated long-term, dietary estrous cyclicity fertility mice. Adult CD-1 mice were fed chow containing vehicle control (corn oil) or 0.15–1500 ppm di(2-ethylhexyl) (DEHP), diisononyl (DiNP), a mixture phthalates (Mix) DEHP, DiNP, benzyl butyl phthalate, di-n-butyl diisobutyl diethyl phthalate. Measurements urinary metabolites confirmed effective delivery phthalates. Phthalate consumption for 11 months did not affect body weight compared to control. DEHP at 0.15 3 5 increased time that spent estrus decreased metestrus/diestrus DiNP (0.15–1500 ppm) significantly Mix 1500 fertility-related indices reduced gestational index birth rate These data indicate chronic alters cyclicity, reduces

Language: Английский

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Preparation of SERS substrate with 2D silver plate and nano silver sol for plasticizer detection in edible oil

Food Chemistry, Journal Year: 2022, Volume and Issue: 409, P. 135363 - 135363

Published: Dec. 30, 2022

Language: Английский

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Determination of 15 phthalic acid esters based on GC–MS/MS coupled with modified QuEChERS in edible oils

Food Chemistry X, Journal Year: 2022, Volume and Issue: 16, P. 100520 - 100520

Published: Nov. 21, 2022

Language: Английский

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Interactions of human drug transporters with chemical additives present in plastics: Potential consequences for toxicokinetics and health

Environmental Pollution, Journal Year: 2023, Volume and Issue: 331, P. 121882 - 121882

Published: May 24, 2023

Language: Английский

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Plasticizers contaminants in water and bottom sediments of the non-flow reservoir: a case study of the Nakło-Chechło, Southern Poland

Journal of Soils and Sediments, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

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Phthalates and Non-Phthalate Plasticizers and Thyroid Dysfunction: Current Evidence and Novel Strategies to Reduce Their Spread in Food Industry and Environment

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 222 - 222

Published: March 19, 2025

Thyroid hormones (THs) play a crucial role in various biological functions, including metabolism, cell growth, and nervous system development, any alteration involving the structure of thyroid gland TH secretion may result disease. Growing evidence suggests that phthalate plasticizers, which are commonly used wide range products (e.g., food packaging materials, children’s toys, cosmetics, medical devices), can impact function, primarily affecting serum levels THs TH-related gene expression. Like compounds, recently introduced alternative plasticizers leach from their source material into environment, particularly foods, although so far only very limited number studies have investigated toxicity. This review aimed at summarizing current knowledge on non-phthalate dysfunction disease, describing major mechanisms underlying this relationship. We will also focus industry as one main players for massive spread such compounds human body, turn conveyed by edible compounds. Given increasing worldwide use essential humans, novel strategies should be envisaged to reduce burden and, general, health.

Language: Английский

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Polystyrene Microplastics‐Induced Thyroid Dysfunction in Mice: A Study of Gene Expression, Oxidative Stress, and Histopathological Changes

Veterinary Medicine and Science, Journal Year: 2025, Volume and Issue: 11(3)

Published: May 1, 2025

ABSTRACT Background Polystyrene microplastics (PS‐MPs) are pervasive pollutants impacting animals across ecosystems, including livestock and wildlife, through contaminated food, water, air. MPs may disrupt endocrine function, particularly affecting the thyroid gland, which is essential for metabolism development. Objectives This study investigates effects of PS‐MPs on function in mice, offering insights relevant to veterinary care by examining changes gene expression biochemical markers. Methods 5 µm diameter were prepared distilled water after probe sonication. Sixty male Swiss albino mice divided into three groups: a control group two treatment groups receiving 0.1 mg 0.2 via oral gavage 28 days. Mice anesthetised, tissues collected histopathological, biochemical, analyses. Biochemical tests included catalase, superoxide dismutase, reactive oxygen species, hormone levels. Histopathology ( TSHR TPO ) thyroid‐related genes examined assess induced effects. Results Exposure led significant increases calcium, thyroxin, free T3, T4, ALP, AST, ALT, amylase levels, alongside elevated oxidative stress Conversely, levels TSH, calcitonin, magnesium phosphate decreased. Histopathological analysis showed abnormal follicle development, decrease parafollicular cells, with colloid loss, haemorrhage, necrosis. Gene revealed marked reduction treated groups, indicating dysfunction. These findings highlight profound impact gland mice. Conclusion underscore potential risks that pose health, consequences other species. As environmental contamination rises, veterinarians encounter more disorders linked PS‐MPs, emphasising need further research preventive measures.

Language: Английский

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Biodegradation of terephthalic acid using Rhodococcus erythropolis MTCC 3951: Insights into the degradation process, applications in wastewater treatment and polyhydroxyalkanoate production

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: unknown

Published: Oct. 5, 2023

Language: Английский

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Boosting plant oil yields: the role of genetic engineering in industrial applications

Biofuel Research Journal, Journal Year: 2024, Volume and Issue: 11(02), P. 2105 - 2145

Published: June 1, 2024

As climate change intensifies and the need to reduce human-caused emissions becomes more urgent, transitioning a bio-based economy is essential. This paper explores diverse industrial applications of plant oils as sustainable alternatives petroleum-based products, including their use in food, polymers, lubricants, surfactants, pesticides, emollients, biofuels. review delves into biosynthetic pathways, detailing key enzymes processes involved synthesis triacylglycerol. It thoroughly discusses how genetic metabolic engineering can not only increase oil yields but also modify fatty acid compositions better meet requirements. By understanding genetics utilizing advanced biotechnologies, content quality sources be significantly enhanced, aligning with both sustainability goals demands. provides comprehensive overview current uses production, proposing innovative strategies such from biomass or cultivating non-edible crops. These approaches aim establish system, reliance on fossil fuels, promote growth an environmentally responsible economy. Additionally, highlights future directions, examining economic implications environmental benefits adopting across various sectors positioning them pivotal achieving eco-friendly,

Language: Английский

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Association of phthalate exposure with low birth weight in couples conceiving naturally or via assisted reproductive technology in a prospective birth cohort

The Science of The Total Environment, Journal Year: 2022, Volume and Issue: 855, P. 158852 - 158852

Published: Sept. 16, 2022

Language: Английский

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