In vitro Evaluation of DINCH-Plasticized Blood Bags for Red Blood Cell Storage with CPDA-1 Anticoagulant

Transfusion Medicine and Hemotherapy, Journal Year: 2024, Volume and Issue: 51(4), P. 274 - 285

Published: Jan. 1, 2024

Di(2-ethylhexyl) phthalate (DEHP) is a plasticizer commonly used in blood bags. Despite its protective effects on red cell (RBC) storage, concerns about reproductive toxicity exist. This study investigated the vitro quality of RBC concentrates stored bags using di(isononyl) cyclohexane-1,2-dicarboxylate (DINCH) as an alternative plasticizer.

Language: Английский

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Low-Glycemic Load Diets and Thyroid Function: A Narrative Review and Future Perspectives

Nutrients, Journal Year: 2024, Volume and Issue: 16(3), P. 347 - 347

Published: Jan. 25, 2024

Nutrition and calorie intake are associated with subtle changes of thyroid function tests in subjects an intact Hypothalamic-Pituitary-Thyroid axis. Iodine deficiency extreme fluctuations intake, such as those that occur during periods starvation or overfeeding could lead to alterations hormones. The dietary macronutrient micronutrient composition also influence the function. Recently, Low-Glycemic Load (LGL) diets have become very popular effective treatment and/or prevention several medical conditions, including diabetes, obesity, cardiovascular disease, epilepsy. In this review, we report on available data from literature regarding association between LGL dysfunction. Several studies conducted field date yielded inconsistent results.

Language: Английский

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Multi‐branched octopus‐like plasticizers with excellent plasticizing performance in poly(vinyl chloride)

Journal of Applied Polymer Science, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 15, 2024

Abstract The development of alternatives is a priority issue for the plasticizer industry due to reproductive toxicity and potential carcinogenicity phthalate plasticizers. Herein we demonstrate synthesis characterization multi‐branched octopus‐like plasticizers applied in poly(vinyl chloride) (PVC). were achieved through straightforward one‐step esterification reaction, resulting four polyol ester (glyceryl tri‐ n ‐octanoate [GTOE], pentaerythritol tetra‐ [PQOE], xylitol penta‐ [XPOE], mannitol hexa‐ [MHOE]). structure enhances interactions between PVC molecules leading superior plasticizing properties, particularly mechanical thermal stability, migration resistance compared with commercial di(2‐ethylhexyl) (DEHP), dioctyl terephthalate (DOTP), acetyl tributyl citrate (ATBC). Concretely, elongation at break MHOE/PVC (825%) PQOE/PVC (814.63%) was better than that DEHP/PVC (670.02%), DOTP/PVC (490.62%) ATBC/PVC (566.78%). T 5% GTOE/PVC, PQOE/PVC, XPOE/PVC, 46.97, 67.24, 60.09 48.14°C higher respectively. In volatility testing after 48 h, weight loss 5.63%, 3.64%, 2.95%, 8.88% respectively, which far less (15.58%), (11.83%) (18.15%). Consequently, obtained enhanced efficiency, presenting promising expanding repertoire choices within industry.

Language: Английский

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Investigation of the effects of phthalates on in vitro thyroid models with RNA-Seq and ATAC-Seq

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 14

Published: Sept. 22, 2023

Phthalates are a class of endocrine-disrupting chemicals that have been shown to negatively correlate with thyroid hormone serum levels in humans and cause state hyperactivity the thyroid. However, their mechanism action is not well described at molecular level. We analyzed response mouse organoids exposure biologically relevant dose range phthalates bis(2-ethylhexyl) phthalate (DEHP), di-iso-decylphthalate (DIDP), di-iso-nonylphthalate (DINP), di-n-octylphthalate (DnOP) for 24 h simultaneously mRNA miRNA expression via RNA sequencing. Using data, we performed differential gene set enrichment analysis. also exposed human follicular epithelial cell line Nthy-ori 3-1 1 µM DEHP or DINP 5 days changes chromatin accessibility ATAC-Seq. Dose-series analysis showed how several genes increased decreased highest tested. As expected low dosing scheme, compounds induced modest on transcriptome, as identified only mmu-miR-143-3p after treatment very few differentially expressed genes. No effect was observed markers. Ing5, component histones H3 H4 acetylation complexes, consistently upregulated three out four conditions compared control, partial overlap among by treatments. Gene samples fatty acid metabolism pathway control pathways related receptor signalling extracellular matrix organization. ATAC-Seq general increase however did identify significant regions. With this work, despite having genes, diverse methods could be applied retrieve information phthalates, showing potential vitro thyroid-relevant systems endocrine disruptors.

Language: Английский

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The future of baby cosmetics packaging and sustainable development: A look at sustainable materials and packaging innovations – A systematic review

Sustainable Development, Journal Year: 2023, Volume and Issue: 32(3), P. 2208 - 2222

Published: Oct. 1, 2023

Abstract Packaging waste's ecological impact, stemming from resource depletion, plastic pollution, and climate concerns, is prompting environmental worries. Within the baby cosmetics domain, management task involves balancing safety, hygiene standards, consumer preferences, regulations, all while adopting eco‐friendly packaging. This study presents a holistic global assessment of sustainable packaging options tailored for sector. By employing systematic methodology encompassing planning using Python programming, data evaluation, analysis, synthesis, investigation scrutinized claims 2048 brands, including 76 specializing in cosmetics. Findings reveal that 39% brands omit material details, 61% embrace recyclable, refillable, or bio‐based alternatives. shift underscores growing sustainability inclination, though undisclosed materials indicate transparency gaps, urging enhanced regulations. Remarkably, only 14 cosmetic among those studied incorporate diverse certifications standards. study's novelty lies its exhaustive analysis solutions It highlights pressing need companies to adopt packaging, ensure transparency, collaborate industry‐wide future

Language: Английский

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Simultaneous and sensitive determination of the main metabolites of the plasticizer DEHP and its substitutes DEHTP, DINCH and TEHTM in human urine by coupling of on-line SPE, UHPLC and tandem mass spectrometry

Analytical Methods, Journal Year: 2022, Volume and Issue: 14(40), P. 3970 - 3981

Published: Jan. 1, 2022

With the prominent but toxicologically critical plasticizer di-(2-ethylhexyl) phthalate (DEHP) declining, alternative plasticizers are increasingly used leading to a continuously more diverse exposure situation of humans with multiple plasticizers. Therefore, an on-line SPE-LC-MS/MS method for simultaneous determination most relevant urinary biomarkers DEHP and 1,2-cyclohexane dicarboxylic acid diisononyl ester (DINCH), terephthalate (DEHTP) tri-(2-ethylhexyl) trimellitate (TEHTM) was developed. The is characterized by high sensitivity limits detection ranging from 0.006 0.047 μg L-1 combined easy straightforward sample preparation procedure. wide linear working range enables reliable analyte background levels in general population as well its potential use monitoring studies investigating elevated settings. successfully applied urine samples ten volunteers without occupational revealing ubiquitous common DEHP, DEHTP DINCH.

Language: Английский

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Supporting legislative action: Urinary levels of phthalates and phenols among influencers in the ‘Plastics in the spotlight’ advocacy initiative

Environmental Research, Journal Year: 2023, Volume and Issue: 231, P. 116205 - 116205

Published: May 20, 2023

Language: Английский

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How body burden from exposure to endocrine disruptors effects accelerated aging?

Environmental Research and Technology, Journal Year: 2023, Volume and Issue: 6(4), P. 383 - 390

Published: Oct. 3, 2023

This paper reviewed various studies on the effects of endocrine disruptors human health, focusing accelerated aging in younger generation. In particular, we analyzed how modern lifestyle and ignorance generation are accelerating aging, concentration disruptor exposure body affects body's burden. Based existing papers, conducted a systematic review using Web Science, Google Scholar, Scopus to comprehensively investigate summarize definition disruptors, their hormones, physical burden continuous disruptors. Research has shown that persistent disrupts homeostasis creates oxidative stress can lead chronic inflammation. These characteristics were also found be significant observation telomere length, which is measure aging. Therefore, order prevent generation, suggest ways minimize slow down normal entire public including 3040s, long term.

Language: Английский

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Phthalate and DINCH metabolites in the urine of Hungarian schoolchildren: cumulative risk assessment and exposure determinants

Environmental Research, Journal Year: 2024, Volume and Issue: 262, P. 119834 - 119834

Published: Aug. 24, 2024

A human biomonitoring study was conducted to assess the exposure of Hungarian children aged 8-11 years ten phthalate esters (PEs) and DINCH between 2017 2018. In addition collecting urine samples from 262 participants, a questionnaire completed by parents or legal guardians identify potential determinants exposure. The highest geometric mean concentration observed for MiBP, followed MBP, cx- MEHP, OH-MEHP MEP. Three out four metabolites were detected in more than 90% samples. comparison urinary concentrations measured this with those DEMOCOPHES revealed significant decreasing trend all PE investigated both studies 2011/2012 2017/2018. Different approaches used health risks associated PEs DINCH. Our results highlighted that hazard index (HI) values higher 1 17.6% when guidance applied. contrast, less 3% had HI exceeding other sources reference used. By applying safety factor 10 risk assessment, 17.6-91.6% characterized 0.1, indicating need reduction measures. Overall, DnBP, DiBP DEHP identified as main drivers mixture risk. Although are ubiquitous contaminants, there still inconsistencies gaps our understanding multivariate regression analysis showed associations metabolite certain individual characteristics, use personal care products, home school environment food beverages consumption 24 h prior sample collection.

Language: Английский

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Role of Zinc Alpha2-Glycoprotein and Retinol-Binding Protein-4 in Iraqi Women with Thyroid Dysfunctions

Iraqi Journal of Science, Journal Year: 2024, Volume and Issue: unknown, P. 5385 - 5394

Published: Oct. 30, 2024

Thyroid dysfunction (TD) and diabetes mellitus (DM) are two of the most frequent chronic endocrine disorders. This study included 60 women with thyroid disorders: 30 hypothyroidism hyperthyroidism, aged between 20 40 years. used healthy 20-40 years as a control group. Anthropometric measurements Body Mass Index (BMI), hematological analysis glycated hemoglobin (HbA1c), biochemical parameters (Thyroid-stimulating hormone TSH, Free triiodothyronine FT3, thyroxine FT4, Fasting Blood Sugar FBS), adipokine concentrations zinc-α2-glycoprotein (AZGP-1) retinol-binding protein-4 (RBP-4) were performed for all participants. The results revealed that serum levels significantly higher in hyperthyroidism (P<0.0001) compared to both hypothyroid women. Besides that, has negative correlation TSH In group, it correlates positively protein-4. addition is correlated FT3 FT4 negatively BMI For this reason, we conclude these adipokines can aid diagnosis monitoring disorders, thereby preventing onset disease complications associated type 2 mellitus. It important highlight more likely than those develop diabetes.

Language: Английский

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