Subchronic oral exposure to polystyrene microplastics affects hepatic lipid metabolism, inflammation, and oxidative balance in gilthead seabream (Sparus aurata)

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 279, P. 116455 - 116455

Published: May 20, 2024

Microplastics (MPs) pose a clear threat to aquatic organisms affecting their health. Their impact on liver homeostasis, as well the potential onset of nonalcoholic fatty disease (NAFLD), is still poorly investigated and remains almost unknown. The aim this study was evaluate outcomes subchronic exposure polystyrene MPs (PS-MPs; 1–20 μm; 0, 25, or 250 mg/kg b.w./day) lipid metabolism, inflammation, oxidative balance in gilthead seabreams (Sparus aurata Linnaeus, 1758) exposed for 21 days via contaminated food. PS-MPs induced an up-regulation mRNA levels crucial genes associated with synthesis storage (i.e., PPARy, Srebp1, Fasn) without modifications involved catabolism PPARα, HL, Pla2) transport metabolism (Fabp1) liver. increase CSF1R pro-inflammatory cytokines gene expression TNF-α IL-1β) also observed fish dose-dependent manner. These findings were confirmed by hepatic histological evaluations reporting evidence accumulation, necrosis. Moreover, caused impairment antioxidant defense system through alteration its enzymatic (catalase, superoxide dismutase, glutathione reductase) non-enzymatic (glutathione) components, resulting increased production reactive oxygen species (ROS) malondialdehyde (MDA), biomarkers damage. detoxifying enzymes inferred decreased Ethoxyresorufin-O-deethylase (EROD) activity glutathione-S-transferase (GST) at highest PS-MP dose. suggests that affect health seabream. dysfunction damage result from detrimental interplay damage, systems modifications, altering gut-liver axis homeostasis. This scenario suggestive involvement MP-induced effects progression

Language: Английский

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Bio inspired heuristic computing scheme for the human liver nonlinear model

Heliyon, Journal Year: 2024, Volume and Issue: 10(7), P. e28912 - e28912

Published: April 1, 2024

In this research, a bio-inspired heuristic computing approach has been developed to solve the nonlinear behavior of human liver, which is categorized into liver and blood. The solutions model are presented by using stochastic computation procedure based on artificial neural network (ANN) along with optimization genetic algorithm (GA) interior-point (IP). A fitness function designed through differential form then optimized hybrid competency GAIP scheme. correctness exactness proposed observed overlapping obtained (GAIP) reference (Adams scheme) solutions, while calculated absolute error values in good order enhance worth solver. log-sigmoid transfer together ten numbers neurons executed perform model. Furthermore, statistical approaches have applied observe reliability for solving

Language: Английский

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Cyhalofop-butyl induced hepatotoxicity of zebrafish through disturbing the gut-liver axis

Microchemical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 112912 - 112912

Published: Jan. 1, 2025

Language: Английский

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Assessing the effects of a commercial fungicide and an herbicide, alone and in combination, on Apis mellifera: Insights from biomarkers and cognitive analysis

Chemosphere, Journal Year: 2024, Volume and Issue: 359, P. 142307 - 142307

Published: May 9, 2024

Agrochemicals play a vital role in protecting crops and enhancing agricultural production by reducing threats from pests, pathogens weeds. The toxicological status of honey bees can be influenced number factors, including pesticides. While extensive research has focused on the lethal sublethal effects insecticides individual colonies, it is important to recognise that fungicides herbicides also affect bee health. Unfortunately, field, are exposed mixtures compounds rather than single substances. This study aimed evaluate commercial fungicide herbicide, both individually combination, bees. Mortality assays, biomarkers learning memory tests were performed, results integrated assess Neurotoxicity (acetylcholinesterase carboxylesterase activities), detoxification metabolic processes (glutathione S-transferase alkaline phosphatase immune system function (lysozyme activity haemocyte count) genotoxicity (nuclear abnormalities assay) assessed. Sakura® was found activate enzymes activity. herbicide Elegant 2FD combination pesticides showed neurotoxic induced processes. Exposure herbicide/fungicide mixture impaired represents significant advance understanding commonly used agriculture contributes development effective strategies mitigate their adverse non-target insects.

Language: Английский

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NUTRITIONAL STUDIES ON FISH CATLA CATLA FOUND IN GANGA RIVER WITH HYDROBIOLOGICAL STUDIES

Journal of Science Innovations and Nature of Earth, Journal Year: 2024, Volume and Issue: 4(2), P. 17 - 22

Published: June 22, 2024

Finding out what other people have said and thought about a certain subject then putting that information into writing is literature review all about. One way to get more knowledgeable in your area do review. Fundamental ideas, research strategies, experimental procedures utilised profession will be covered. Discover real-world challenges. further advantage of reading reviews you gain better grasp the presentation discussion findings specific field. Improving skills for field as simple paying close attention others written attempting adopt their style. The purpose reviewing nutritional studies on fish Catla catla found Ganga river with hydrobiological understand effects environmental factors, especially heavy metal pollution, quality health. an important food feeds plankton occupies upper layer water column. It widely distributed India South Asian countries. However, facing severe threats from various anthropogenic activities such industrial effluents, mining waste, agricultural runoff, domestic sewage. These sources introduce metals nickel thallium water, which can build up tissues, leading histopathological alterations, immunotoxicity, genotoxicity, oxidative stress. As result, keeping eye samples levels crucial, determining fish's profile terms calories, ash, protein, carbohydrates, lipids. To assess how contamination affects diversity quality, it necessary compare data places times year. Insights gained this also help ecosystem management resource conservation.Even if isn't required class or major project, it's still good idea so you're up-to-date discussions surrounding choice. become equipped construct argument uniquely yours.

Language: Английский

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Behavioral, biochemical, immune, and histological responses of Nile tilapia (Oreochromis niloticus Linnaeus, 1758) to lead, mercury, and pendimethalin exposure: individual and combined effects

Environmental Sciences Europe, Journal Year: 2025, Volume and Issue: 37(1)

Published: Jan. 15, 2025

Abstract The aquaculture sector is facing environmental issues because of rising chemical pollution aquatic systems, which may be caused by man-made or natural causes. combined action these mixtures can produce an effect that either severalfold higher lower than the overall toxicity individual components. objective this study to evaluate impact three toxicants: lead (Pb 0.088 mg L −1 ), mercury (Hg 0.084 and pendimethalin (PM 0.355 ) their combinations on behavior, oxidative stress, immunology, biochemistry, histopathological changes in Nile tilapia. results show mortality was evident across all treatment groups highest mixture (MIX) group, at 33.4%. Some behavioral included increased mucus secretion, fin rot, dark skin coloration fish, were evidently exacerbated MIX group. erythrocyte hemoglobin indices presented marked reductions PM comparison control group had levels serum creatinine urea, as well liver enzymes alanine aminotransferase, aspartate transaminase, alkaline phosphatase. They also malondialdehyde total antioxidant capacity, showed stress. stress biomarkers, cortisol glucose, greater groups. neurobehavioral assessment demonstrated noticeable decreased acetylcholinesterase MIX-exposed In immunological parameters, nitric oxide lysozyme lower, especially experimental groups, spleen pro-inflammatory cytokine genes higher. examination revealed lesions gills, liver, brains form inflammation, necrosis, circulatory alterations. Among exposed exhibited changes. Collectively, our findings significant toxic effects heavy metals herbicides tilapia, revealing a synergistic both physiological responses resulting from exposures. data indicate ecological hazards associated with ecosystems.

Language: Английский

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An improved ultrasound-assisted extraction (UAE) and HPLC-PDA methods for multiclass analysis of pharmaceutical residues in fish

Journal of Liquid Chromatography &amp Related Technologies, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 8

Published: Feb. 12, 2025

Language: Английский

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Chronic Exposure to Palm Oil Mill Effluent Induces Oxidative Stress and Histopathological Changes in Zebrafish (Danio rerio)

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 490, P. 137844 - 137844

Published: March 4, 2025

Language: Английский

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Influences of Parasitic Stress on the Health Condition of African Catfish (Clarias gariepinus): Biochemical and Histopathological Alterations

Molecular and Biochemical Parasitology, Journal Year: 2025, Volume and Issue: unknown, P. 111677 - 111677

Published: March 1, 2025

Language: Английский

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Impact of Temperature Reduction from 14 °C to 12 °C in RASs on Atlantic Salmon: Increased Mineral Accumulation in RASs and Enhanced Growth Post-Transfer to Seawater

Water, Journal Year: 2025, Volume and Issue: 17(6), P. 803 - 803

Published: March 11, 2025

Robust, healthy, and fast-growing smolt is of high importance for fish farmers as a way reducing the mortality production time Atlantic salmon (Salmo salar) in open sea pens. Lowering water temperature flow-through systems (FTSs) compared to recirculating aquaculture (RASs) has shown promising results growth health post-transfer sea; unfortunately, limited information available on same parameters replicated RAS setups. Hence, current study aimed compare performance reared at 12 14 °C over 9-week period subsequent 10-week period, while also investigating accumulation pattern minerals RASs. The showed 100% survival comparable condition factors cardiosomatic index (CSI) across both temperatures. During thermal coefficient (TGC) was higher °C, but body weight gain feed consumption were lower. No differences mineral retention or fecal stability observed. However, accumulated more dissolved phosphorus (DP) total iron (Fe) °C. Post-transfer, TGC remained with rearing history This had exhibiting lower hepatosomatic (HSI) viscerosomatic (VSI), indicating improved muscle growth. Overall, reduced increased DP Fe it tissue, highlighting its benefits seawater performance.

Language: Английский

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