The global burden and biomarkers of cardiovascular disease attributable to ambient particulate matter pollution

Journal of Translational Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 22, 2025

Understanding the evolving patterns of cardiovascular disease (CVD) burden attributable to ambient particulate matter pollution (APMP) is essential. Furthermore, research on underlying mechanisms has mostly been limited laboratory and animal models, with few large-scale population-based studies. Using data from Global Burden Disease Study (GBD) 2021, we analyzed disability-adjusted life years mortality for CVD APMP (measured as [PM]2.5) 1990 2021. We examined shifts in between household air (HAP), regional disparities by socio-demographic index (SDI), predicted trends using a Bayesian age-period-cohort model. Additionally, used UK Biobank (UKB) (metabolomics: 230,000 + participants; proteomics: 50,000 +) identify biomarkers mediating association PM2.5 exposure outcomes, further their biological roles. Metabolic proteomic signatures were constructed regression elastic net predictive performance assessed via time-dependent receiver operating characteristic analysis. Life expectancy was evaluated flexible parametric survival models. Subgroup analysis conducted age, sex, lifestyle, socioeconomic status, genetic susceptibility. In global absolute more than double that 1990, significant disparities. The shifted HAP APMP, 15% cases globally attributed APMP. increased age projected rise through 2030. UKB, approximately 30 metabolites, including albumin, mediated primarily involving lipid fatty acids metabolism. Over 60 proteins, growth differentiation factor-15 trefoil factor 2, enriched cytokine-receptor interaction leukocyte migration pathways. outperformed alone predicting 1-, 5-, 10-year outcomes. Participants lowest decile exposure, metabolic, had longer those highest decile. remains critical public health concern. This study presents novel approach identifying managing susceptible populations metabolomic perspectives.

Language: Английский

Circulating Metabolomics Revealed Novel Associations between Multiple Ambient Air Pollutants Exposure and Chronic Obstructive Pulmonary Disease Incidence: Evidence from A Prospective Cohort Study.

Environmental Pollution, Journal Year: 2024, Volume and Issue: 359, P. 124727 - 124727

Published: Aug. 13, 2024

Language: Английский