Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 290, P. 117559 - 117559
Published: Dec. 17, 2024
Language: Английский
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 172008 - 172008
Published: March 26, 2024
Language: Английский
Citations
7
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: Jan. 10, 2025
As glyphosate's application becomes increasingly widespread across the globe, its potential adverse effects on humans have garnered growing concerns. Little evidence has revealed associations between glyphosate and glucose homeostasis. A total of 2094 individuals were recruited from NHANES 2013–2018. Urinary glyphosate, alkaline phosphatase (ALP), fasting plasma (FPG), insulin, glycated hemoglobin A1c (HbA1c) measured. Homeostatic model assessment beta-cell function (HOMA2-β), insulin resistance (HOMA2-IR), sensitivity (HOMA2-IS) assessed. Generalized linear models mediation analyses fitted to estimate homeostasis, ALP. demonstrated a statistically significant positive association with FPG HbA1c in dose–response manner, while showing negative HOMA2-β. Each doubling increase urinary was associated 1.13%, 1.50%, − 2.80% alteration FPG, HbA1c, HOMA2-β, respectively. Obesity modified dyshomeostasis stronger obese individuals. In addition, elevated ALP significantly mediated proportions 9.91% 20.23%, Environmental exposure dyshomeostasis, which more pronounced partly by
Language: Английский
Citations
1
Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 290, P. 117776 - 117776
Published: Jan. 1, 2025
People are continually and simultaneously exposed to various non-persistent pesticides as these chemicals ubiquitously distributed in the environment. Toxicological studies have indicated associations between liver fibrosis vitro vivo. However, epidemical study on deleterious effect of risk is rather limited. To examine relationship mixed exposure fibrosis, identify potential significant importance, this enrolled representative individuals from NHANES 2013-2016 survey cycles, which urinary were measured. Liver was determined based alternative noninvasive tests Fibrosis-4 index (FIB-4) Hepamet Fibrosis Score (HFS). Survey-weighted linear/logistic regression Bayesian kernel machine (BKMR) used detected independent combined respectively. In single analysis, persistent identified for 3,5,6-trichloropyridinol (TCPY), para-nitrophenol (PNP), glyphosate (GLYP) 2,4-dichlorophenoxyacetic acid (2,4-D) with both continuous dichotomous outcomes. Of them, TCPY GLYP had highest estimates, corresponding FIB-4 coefficient (β) being 0.09 (0.05-0.13, model 3) (0.06-0.12, 3), BKMR positive mixture HFS identified. The results Posterior Inclusion Probability (PIP) further showed that GLYP, TCPY, PNP main contributors overall effects mixture, PIPs 1.000 (1.000), (0.914) 0.972 (0.819) (HFS) This indicates associated increased humans, provide new insight into hepatotoxic pesticides.
Language: Английский
Citations
0
PLoS ONE, Journal Year: 2025, Volume and Issue: 20(1), P. e0317908 - e0317908
Published: Jan. 24, 2025
Background Glyphosate, as the main component of glyphosate pesticides, has been shown to have toxic effects on multiple human systems. However, association between and atherosclerotic cardiovascular disease (ASCVD) remains unclear. This study aims explore effect exposure ASCVD. Methods involved 1,602 participants employed various statistical techniques, such multivariable logistic regression, linear fitting, mediation analysis, subgroup sensitivity elucidate diseases. Results Compared with low level exposure, risk ASCVD increased significantly high (OR = 2.05, 95%CI 1.17–3.58, p<0.05, p for trend<0.05), which showed a upward trend. Further analysis found that levels angina pectoris 2.84, 1.00–8.04, coronary heart 3.76, 1.80–7.83, p<0.01, attack 2.65, 1.35–5.23, trend 0.09) were associated. Mediating BMI mediated ASCVD, an indirect 0.002405(95%CI: 0.000182–0.01, 0.02) direct 0.039336(95%CI: 0.000391–0.09), total 0.041741(95%CI: 0.002112–0.10). Conclusion Increased is associated plays mediating role in this association. In addition, higher angina, disease, attack.
Language: Английский
Citations
0
Environmental Toxicology and Pharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 104705 - 104705
Published: April 1, 2025
Language: Английский
Citations
0
Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 275, P. 116266 - 116266
Published: April 1, 2024
Glyphosate, ranked as one of the most widely used herbicides in world, has raised concerns about its potential disruptive effects on sex hormones. However, limited human evidence was available, especially for children and adolescents. The present study aimed to examine associations between exposure glyphosate hormones among participants aged 6-19 years, utilizing data from National Health Nutrition Examination Survey (NHANES) conducted 2013 2016. Children adolescents who had available urinary glyphosate, serum steroid hormones, including testosterone (TT), estradiol (E
Language: Английский
Citations
2
International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 7039 - 7039
Published: June 27, 2024
Glyphosate, the active ingredient of several broad-spectrum herbicides, is widely used throughout world, although many adverse effects are known. Among these, it has been recognized as an endocrine disruptor. This work aimed to test and potential disrupting action glyphosate on PNT1A human prostate cells, immortalized non-tumor epithelial cell line, possessing both ERα ERβ estrogen receptors. The results showed that induces cytotoxicity, mitochondrial dysfunction, rapid activation via nuclear translocation. Molecular analysis indicated a possible involvement apoptosis in glyphosate-induced cytotoxicology. apoptotic process could be attributed alterations metabolism; therefore, main parameters functionality were investigated using Seahorse analyzer. Impaired function was observed glyphosate-treated with reductions ATP production, spare respiratory capacity, proton leakage, along increased efficiency coupling. Finally, immunofluorescence demonstrated acts disruptor determining translocation ERs. Nuclear occurred independent dose, faster than specific hormone, persisted treatment. In conclusion, collected show cells can cause death xenoestrogen, activating consequent alteration hormonal functions have negative reproductive health exposed animals, compromising their fertility.
Language: Английский
Citations
2
Toxics, Journal Year: 2024, Volume and Issue: 12(8), P. 559 - 559
Published: July 31, 2024
Glyphosate is the most widely used herbicide in world. This study aimed to evaluate relationships among urinary glyphosate, all-cause mortality and cardiovascular diseases (CVD)-related general US population of adults, determine role alkaline phosphatase (ALP), an inflammation marker that associated with glyphosate exposure, these relationships. Subjects from National Health Nutrition Examination Survey (NHANES) 2013-2018 cycles were included. Survey-weighted Cox regression analysis was applied estimate relationship overall CVD mortalities. Restricted cubic spline (RCS) utilized detect linearity associations. The intermediary ALP explored by mediation analysis. Our results found consistent positive associations (HR: 1.29, 95%CI: 1.05-1.59) 1.32, 1.02-1.70). RCS curves further validated linear dose-dependent between mortality-related outcomes. Moreover, serum identified as a mediator explained 12.1% 14.0% total death risk, respectively. indicated increased humans. Increased may play essential
Language: Английский
Citations
2
Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 290, P. 117559 - 117559
Published: Dec. 17, 2024
Language: Английский
Citations
1