The relationship between serum monoterpene levels and bone health: a retrospective cross-sectional analysis from the National Health and Nutrition Examination Survey (NHANES) data

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: Aug. 7, 2024

Introduction Monoterpenes, a subset of the terpene family composed two isoprene units, have garnered significant attention in research circles owing to their potential medicinal benefits. Recent experimental studies indicate that they might exert positive effects on bone health. Nevertheless, impact monoterpenes exposure health remains unexplored humans. Methods We examined 748 adults (age ≥ 40 years) from National Health and Nutrition Examination Survey (NHANES) 2013–2014 explore correlation between three (α-pinene, β-pinene, limonene), mineral density (BMD) total lumbar spine proximal femur, FRAX ® scores, prior fracture history. Results discussion Our analysis unveiled inverse association one-unit increase natural logarithm (ln) α-pinene limonene femur BMD (ß = −0.027, S.E. 0.008, P 0.004 ß −0.019, 0.007, 0.016, respectively). As serum levels ascended across quintiles, there was notable decrease ( for trend 0.025). The relationship ln more pronounced women, especially pre-menopausal women. Compared subjects with at or below 50 th percentiles, those exceeding this threshold exhibited lowest mean value (0.8628 g/cm2, 0.026, 0.009). However, not statistically 0.070). Additionally, all were linked higher prevalence previous fractures, whereas β-pinene showed reduced incidence other types fractures. In comprehensive survey American aged above, correlated decreased BMD. Furthermore, our findings suggest combined effect Further investigation is essential elucidate clinical relevance causative nature findings.

Language: Английский

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Association of Serum Levels of Terpenes With Metabolic Syndrome and Its Components in Adults

Indoor Air, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Aim: Environmental exposure constitutes a significant determinant in the pathogenesis of metabolic syndrome (MetS). Nevertheless, contribution environmental factors to MetS remains ambiguous. The present study was aimed at investigating correlation between serum terpenes and risk general population. Methods: A cross‐sectional conducted among 1266 individuals from 2013–2014 National Health Nutrition Examination Survey (NHANES). Serum were analyzed using weighted logistic regression model. Weighted quantile sum (WQS) utilized explore relationship mixture MetS. restricted cubic spline (RCS) method employed assess dose–response them. All data analyses “Survey” package R software (Version 4.3.2). Results: population, with an average age 46.82 ± 0.46 years body mass index (BMI) 28.97 kg/m 2 , consisted 48.15% males 67.99% Whites. Among participants, 35.78% diagnosed showed that tertiles levels α ‐pinene, β limonene positively correlated OR value 1.90 (1.14, 3.16), 2.02 (1.23, 3.31), 2.35 (1.33, 4.13) elevated triglycerides (TGs) 2.36 (1.63, 3.43), 3.51 (2.30, 5.38), 3.96 (2.55, 6.15) (all p trend < 0.05). WQS indicated positive association terpene (OR = 1.65, 95% CI: 1.18–2.3), increased TG 2.69, 1.94–3.71), reduced high‐density lipoprotein cholesterol (HDL‐C) 1.46, 1.03–2.07) 0.01). RCS analysis further supported relationship. Conclusion: This suggested potential adverse effects on human health, emphasizing importance interventions maintaining health.

Language: Английский

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Monoterpenes in Your Beverage: A Flavoring Catalyst for Faster Aging?

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 8, 2024

Background Aging is characterized by the progressive deterioration of tissue structure and physiological functions. While impact sugar artificial sweeteners in beverages on biological aging, mediated through increased body mass index (BMI) obesity, has been well-documented, potential effects other food additives, particularly monoterpenes, have not thoroughly explored. This study aimed to investigate association between high exposure monoterpenes age acceleration. Methods Included current were 1,217 adults from National Health Nutrition Examination Survey (NHANES) 2013–2014. Beverage intake was assessed 24-hour dietary recall. Serum levels three monoterpenes—limonene, α-pinene, β-pinene used estimate monoterpene exposure. Biological using phenotypic (PA), with acceleration calculated as difference chronological age. Multiple statistical approaches, including linear regression, restricted cubic spline (RCS) models, quantile g-computation (Qgcomp), Bayesian kernel machine regression (BKMR), employed analyze associations beverage intake, aging. Furthermore, mediation analyses conducted explore BMI PA Results High (β = 0.94, 95% CI: 0.26, 1.62) limonene 1.65, 0.55, 2.76) 1.35, 0.53, 2.18), associated accelerated PA. In RCS analyses, exhibited both nonlinear. Qgcomp model, mixed had a significant positive relationship 0.25, 0.12, 0.37). Moreover, we observed antagonistic each α-pinene concerning aging BKMR model. Additionally, identified parallel mediators Conclusion The provides novel insights into detrimental exposures These findings highlight importance considering broader range additives public health guidelines, their long-term outcomes may be significant.

Language: Английский

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Assessing the effects of HMGCR, LPL, and PCSK9 inhibition on sleep apnea: Mendelian randomization analysis of drug targets

Medicine, Journal Year: 2024, Volume and Issue: 103(43), P. e40194 - e40194

Published: Oct. 25, 2024

To investigate the use of lipid-lowering drugs and abnormal serum lipid levels in patients at risk sleep apnea syndrome. Three types Mendelian randomization (MR) analyses were used. First, a 2-sample (TSMR) analysis was used to association between syndrome levels. Multivariate (MVMR) subsequently effects confounding variables on SAS incidence Finally, drug-target (DMR) analyze drug risk. According TSMR analysis, HDL-C concentration negatively correlated with (OR = 0.904; 95% CI 0.845–0.967; P .003). Serum TG positively 1.081; 1.003–1.163; .039). The MVMR consistent results 0.731; 0.500–1.071; 3.94E−05). our DMR HMGCR PCSK9, which act by lowering LDL-C levels, inversely associated 0.627; 0.511–0.767; 6.30E−06) 0.775; 0.677–0.888; .0002). LPL, that lowered 1.193; 1.101–1.294; 1.77E−05). Our suggested high may reduce Low have protective effect against (such as statins) PCSK9 inhibitors has However, LPL-based increase

Language: Английский

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Terpene mixtures and metabolic syndrome in the US general population: exploring the mediating role of insulin resistance

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: Dec. 26, 2024

Language: Английский

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