Microplastics – A Growing Concern as Carcinogens in Cancer Etiology: Emphasis on Biochemical and Molecular Mechanisms

Cell Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 82(4), P. 3109 - 3121

Published: July 20, 2024

Language: Английский

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Factors influencing the distribution, risk, and transport of microplastics and heavy metals for wildlife and habitats in “island” landscapes: From source to sink

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 476, P. 134938 - 134938

Published: June 17, 2024

Microplastics (MPs) and heavy metals (HMs) are important pollutants in terrestrial ecosystems. In particular, the "island" landscape's weak resistance makes it vulnerable to pollution. However, there is a lack of research on MPs HMs island landscapes. Therefore, we used Helan Mountain as area. Assess concentrations, spatial distribution, ecological risks, sources, transport soil blue sheep (Pseudois nayaur) feces. Variations geographical distribution showed connection between human activity pollutants. Risk assessment indicated wildlife were influenced by long-term pollutant polarization multi-element inclusion (I

Language: Английский

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Impacts of micro- and nanoplastics on early-life health: a roadmap towards risk assessment

Microplastics and Nanoplastics, Journal Year: 2024, Volume and Issue: 4(1)

Published: July 2, 2024

Abstract Micro- and nanoplastics (MNPs) are ubiquitous environmental pollutants representing a concern for human health. MNPs have been detected in placentas, indicating that during pregnancy maternal exposure may lead to placental transfer foetal exposure, with potential adverse effects on early-life development. However, comprehensive risk assessment (RA) framework, specific is lacking. Here, we propose novel roadmap assist the development of an health RA MNPs. This designed based established chemical, mixture, particle, MNP strategies aligned standard components (problem formulation, hazard identification, characterisation, assessment, characterisation). We systematically work through these stages identify what needed progress impacts MNPs, including information missing, be used interim. While challenges such as complex physicochemical properties limited toxicity data at relevant levels, uncertainties related characterising exposures described elsewhere, our discusses how specifically impact significance presence biological samples factors influencing bioaccumulation transfer. Additionally, introduce new technology readiness levels methods detection matrices. Importantly, this review integrates broad scope into one document, providing unified resource. highlight requirements areas targeted research, dose-response relationships assessing By addressing gaps, aims advance robust ultimately enhancing understanding mitigation risks associated

Language: Английский

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Exploring the Classic and Novel Pathogenetic Insights of Plastic Exposure in the Genesis and Progression of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Livers, Journal Year: 2025, Volume and Issue: 5(2), P. 21 - 21

Published: May 2, 2025

The term “plastics” is an umbrella generally referring to any material containing a high level of polymer content as essential ingredient. Micro(nano)plastics (MNPs) are derived from the degradation plastics, representing exogenous substances whose exposure can potentially interfere with different physiological processes. In this scenario, even considering relative paramount detoxification role, liver emerges key active organ in relationship between plastic and human disease. industrialized countries, where plastics constitute largely diffused components objects routinely adopted daily/social life, including food packaging, Metabolic dysfunction-associated Steatotic Liver Disease (MASLD) represents predominant hepatopathy progressively becoming leading cause cirrhosis cancer, incompletely elucidated multifactorial pathogenesis. Notably, oral MNPs has been revealed impact gut–liver axis by influencing gut microbiota composition, gastrointestinal absorption, and, ultimately, determining hepatic accumulation. At level, contribute onset worsening steatosis inducing metabolic dysfunction inflammation. Plastics also serve vectors for toxic additives, specific constituting persistent source release bisphenol A (BPA), well-recognized etiological factor contributing MASLD genesis worsening. Recently, additives demonstrated significant impacts on immune system, oxidative stress, metabolism. particular, polystyrene-derived impair mechanisms regulating lipid metabolism, simultaneously acting antigens abnormally triggering innate response. same time, environmental BPA trigger trained immunity-related pathways, configuring novel pathogenetic drivers promoting progression MASLD. present review, after rapidly overviewing main sources toxicological properties related explores plastic-related exposure’s potential implications steatosis, highlighting urgent need further clarification mechanisms.

Language: Английский

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Synergistic toxicity of nanoplastics and Helicobacter pylori on digestive system in mice

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 290, P. 117757 - 117757

Published: Jan. 1, 2025

Nanoplastics, in combination with pathogenic microorganisms or toxic substances, have been shown to induce oxidative stress and disrupt energy lipid metabolism, posing significant health risks. This study evaluated the effects of co-exposure nanoplastics Helicobacter pylori on digestive system mice. Transmission electron microscopy confirmed accumulation AuPS-NPs (Au-core polystyrene nanoplastics) stomach, colon, liver, while hematoxylin eosin staining revealed dose-dependent pathological damage these tissues. Enzyme-linked immunosorbent assays quantified interleukin-6 (IL-6), malondialdehyde (MDA), triglyceride (TG), lactate dehydrogenase (LDH) levels, which significantly increased groups compared single-exposure (P < 0.05). After 28 days, 100 mg/L H. pylori-AuPS-NPs group showed highest levels IL-6 (172.91 ± 1.51 pg/mL 188.31 1.49 174.85 0.26 liver) MDA (13.49 0.16 nmol/mg 14.39 0.20 15.61 0.63 liver). These increases, accompanied by elevated TG LDH suggest aggravated inflammation, stress, metabolic disruption. Accumulation analysis that content over time higher concentrations, reduced nanoparticle gastric intestinal results indicate exacerbates tissue damage, disruptions modulating accumulation. findings highlight synergistic pylori, underscoring importance understanding combined exposure risks for public health.

Language: Английский

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Dust Fall Microplastics from a Megacity of China Inhibit Autophagy via the PI3K/Akt/mTOR Pathway

Environment & Health, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 26, 2025

Language: Английский

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Global Research Hotspots and Progress on Acrylamide: Visualization Analysis

Environmental Health Insights, Journal Year: 2025, Volume and Issue: 19

Published: March 1, 2025

Acrylamide is a contaminant prevalent in many commonly consumed foods, contributing to unavoidable human exposure. It recognized as likely be carcinogenic humans well, provoking global concerns. Numerous studies have investigated the impacts of acrylamide formation on food and drink, nutrition, health. The intent this analysis quantify research, evaluate recent developments, recognize emerging trends, along with assessing research dynamics an indicator innovation among scientific community. Scopus database was used perform in-depth investigation publications from 1949 2023. Exploring prominent topics knowledge network related topic conducted via VOSviewer version 1.6.20. Additionally, using SciMAT software, intellectual identify both driving themes acrylamide-related research. A total 11 880 were identified, 10 720 (90.24%) being original articles. leading contributors terms publication output China (n = 2452; 20.64%), followed by USA 1564; 13.16%), India 952; 8.01%). predominant associated (a) functionalization polymers (b) mitigation drinks. Driving that will continue shape future involve unraveling synthesis acrylamide; deploying nanocomposites increase removal; investigating genotoxicity acrylamide, well its carcinogenic, reproductive, neurotoxic effects; researching adsorption characteristics aqueous solutions. In particular, increased focus has been placed understanding years, signifying attention alignment latest advancements field. creation plans way significant, particularly shaping health policies.

Language: Английский

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Impacts of microplastics on gut health: Current status and future directions

Indian Journal of Gastroenterology, Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Language: Английский

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Microplastic Pollution on the Beaches of the Black Sea in Romania and Bulgaria

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(9), P. 4751 - 4751

Published: April 25, 2025

Microplastic pollution has gained attention in recent years due to its adverse impact on the environment. As a major threat marine ecosystems and biota, accumulation of microplastics along coastlines become growing concern. This study focused quantifying characterizing presence, distribution, composition beaches Romania Bulgaria. Microplastics were extracted from beach sand samples using saturated NaCl solution. The particles then analyzed through FT-IR DSC spectral analyses identify their chemical composition. Sampling was conducted across several resorts Romanian Bulgarian coastlines. findings revealed varying concentrations different beaches, with showing between 40 213 per sample (470–2500 microplastics/kg), which notably higher areas like Mamaia Costinești. On average reached up 137 (1612 particularly Sunny Beach Nessebar. Polyethylene (PE) identified as most prevalent polymer (55%), followed by polyamide (PA), polypropylene (PP), polyethylene terephthalate (PET), polyurethane (PU). These polymers linked common sources such packaging, textiles, industrial products. Microscopic examination, combined analysis, confirmed plastic nature particles, revealing distinct structures characteristic each material type. underscores widespread contamination microplastics, emphasizing environmental risks coastal ecosystems. presence synthetic highlights urgent need for policies targeting waste management mitigate environments.

Language: Английский

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Factors Influencing the Distribution, Risk, and Transport of Microplastics and Heavy Metals for Wildlife and Habitats in “Island” Landscapes: From Source to Sink

Published: Jan. 1, 2024

Microplastics (MPs) and heavy metals are (HMs) important pollutants in terrestrial ecosystems. In particular, the "island" landscape's weak resistance makes it vulnerable to pollution. However, there is a lack of research on MPs HMs island landscapes. Therefore, we used Helan Mountain as area. Assess concentrations, distribution, risks, sources, transport soil Pseudois nayaur feces. The concentrations were 62.58 72.72 particles/g, 213.38 513.87 mg/kg feces soil, respectively. Variations geographical distribution indicate connection between human activity pollutants. Soil wildlife influenced by long-term pollutant polarization multi-element inclusion. Source apportionment showed that tourism coal combustion primary sources coupling models indicated contribution pollution ecological risk did not depend their concentration pollutants, but opposite was true for health risks. Additionally, observed distinctive "source-sink-source" cycle transporting. propose establishing monitoring system formulating effective policies control reduce regional differences. This study provides theoretical foundation future toxicity combined environments.

Language: Английский

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