Semaglutide mitigates testicular damage in diabetes by inhibiting ferroptosis

Biochemical and Biophysical Research Communications, Journal Year: 2024, Volume and Issue: 715, P. 149996 - 149996

Published: April 24, 2024

Language: Английский

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Curcumin: A Potential Detoxifier Against Chemical and Natural Toxicants

Phytotherapy Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 24, 2025

ABSTRACT The human body gets exposed to a variety of toxins intentionally or unintentionally on regular basis from sources such as air, water, food, and soil. Certain can be synthetic, while some are biological. affect the various parts by activating numerous pro‐inflammatory markers, like oxidative stresses, that tend disturb normal function organs ultimately. Nowadays, people use different types herbal treatments, viz., drinks contain spices for detoxification their bodies. One example is turmeric, most commonly available spice in kitchen used across all kinds households. Turmeric contains curcumin, which natural polyphenol. Curcumin medicinal compound with biological activities, antioxidant, antineoplastic, anti‐inflammatory, antibacterial. Hence, this review gives comprehensive insight into promising potential curcumin heavy metals, carbon tetrachloride, drugs, alcohol, acrylamide, mycotoxins, nicotine, plastics. encompasses diverse animal‐based studies portraying curcumin's role nullifying toxic effects (especially liver, kidney, testicles, brain) enhancing defensive signaling pathways, improving antioxidant enzyme levels, inhibiting markers activities so on. Furthermore, also argues over safety assessment its utilization detoxifying agent.

Language: Английский

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Peroxiredoxin 6 in Stress Orchestration and Disease Interplay

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 379 - 379

Published: March 23, 2025

As a moonlighting protein with multiple enzymatic activities, peroxiredoxin 6 (PRDX6) maintains redox homeostasis, regulates phospholipid metabolism, and mediates intra- inter-cellular signaling transduction. Its expression activity can be regulated by diverse stressors. However, the roles relevant mechanisms of these regulators in various conditions have yet to comprehensively reviewed. In this study, stressors were systematically reviewed both vivo vitro classified into chemical, physical, biological categories. We found that regulatory effects on PRDX6 primarily mediated via key transcriptional factors (e.g., NRF2, HIF-1α, SP1, NF-κB), micro-RNAs, receptor- or kinase-dependent pathways. Additionally, certain stressors, including reactive oxygen species, pH fluctuations, post-translational modifications, induced structure-based functional switches enzyme. further altered under disease conditions, particular focus neuropsychiatric disorders cancers, proposed concept PRDX6-related (PRD), which refers spectrum diseases associated dysregulated expression. Finally, we an exogenous supplementation provided preventive therapeutic potentials for oxidative stress-related injuries models. Taken together, review underscores critical role as cellular orchestrator response highlighting its clinical potential monitoring development strategies.

Language: Английский

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Dibutyl phthalate exposure induced mitochondria-dependent ferroptosis by enhancing VDAC2 in zebrafish ZF4 cells

Environmental Pollution, Journal Year: 2024, Volume and Issue: 348, P. 123846 - 123846

Published: March 26, 2024

Language: Английский

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