In vivo evaluation of selenium-tellurium based nanoparticles as a novel treatment for bovine mastitis DOI Creative Commons
Ludmila Košarišťanová, Zuzana Bytešníková, Tatiana Fialová

et al.

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 20, 2024

Abstract Background Bovine mastitis is one of the main causes reduced production in dairy cows. The infection mammary gland mainly caused by bacterium Staphylococcus aureus, whose resistant strains make treatment with conventional antibiotics very difficult and result high losses. Therefore, it important to develop novel therapeutic agents overcome resistance mastitis-causing strains. In this study, selenium-tellurium based nanoparticles (SeTeNPs) were synthesized characterized. Their antibacterial activity biocompatibility evaluated both vitro vivo using a bovine model. A total 10 heifers divided into experimental control groups (5 animals each). After intramammary methicillin S. aureus (MRSA) development clinical signs mastitis, dose SeTeNPs was administered all quarters group. Results Based on tests, concentration 149.70 mg/L 263.95 Se Te, respectively, used for application gland. Three days after administration, MRSA counts group showed significant reduction ( P < 0.01) compared inhibitory effect observed within experiments thus confirmed, resulting suppression animals. Moreover, superior organism demonstrated, as did not significantly alter inflammatory response or histopathology at site application, i.e., gland, > 0.05). Additionally, metabolic profile blood plasma well histology organs remained unaffected, indicating that had no adverse effects organism. Conclusions Our findings suggest can be promising presence bacteria. However, current study limited its small sample size, making primarily proof concept efficacy intramammary-applied SeTeNPs. further research larger size needed validate these results.

Language: Английский

Nano–Bio Interaction and Antibacterial Mechanism of Engineered Metal Nanoparticles: Fundamentals and Current Understanding DOI
Atul Tiwari, P.C. Pándey, Munesh Kumar Gupta

et al.

Journal of Cluster Science, Journal Year: 2024, Volume and Issue: 36(1)

Published: Dec. 2, 2024

Language: Английский

Citations

4
In vivo evaluation of selenium-tellurium based nanoparticles as a novel treatment for bovine mastitis DOI Creative Commons
Ludmila Košarišťanová, Zuzana Bytešníková, Tatiana Fialová

et al.

Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology, Journal Year: 2024, Volume and Issue: 15(1)

Published: Dec. 20, 2024

Abstract Background Bovine mastitis is one of the main causes reduced production in dairy cows. The infection mammary gland mainly caused by bacterium Staphylococcus aureus, whose resistant strains make treatment with conventional antibiotics very difficult and result high losses. Therefore, it important to develop novel therapeutic agents overcome resistance mastitis-causing strains. In this study, selenium-tellurium based nanoparticles (SeTeNPs) were synthesized characterized. Their antibacterial activity biocompatibility evaluated both vitro vivo using a bovine model. A total 10 heifers divided into experimental control groups (5 animals each). After intramammary methicillin S. aureus (MRSA) development clinical signs mastitis, dose SeTeNPs was administered all quarters group. Results Based on tests, concentration 149.70 mg/L 263.95 Se Te, respectively, used for application gland. Three days after administration, MRSA counts group showed significant reduction ( P < 0.01) compared inhibitory effect observed within experiments thus confirmed, resulting suppression animals. Moreover, superior organism demonstrated, as did not significantly alter inflammatory response or histopathology at site application, i.e., gland, > 0.05). Additionally, metabolic profile blood plasma well histology organs remained unaffected, indicating that had no adverse effects organism. Conclusions Our findings suggest can be promising presence bacteria. However, current study limited its small sample size, making primarily proof concept efficacy intramammary-applied SeTeNPs. further research larger size needed validate these results.

Language: Английский

Citations

2