Association between Blood Trihalomethane Concentrations and the Risk of Dyslipidemia: Nationally Representative Cross-Sectional Study DOI
Zihao Xu,

Xu-Lian Tang,

Hong-Xuan Huang

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Experimental studies have indicated that exposure to disinfection byproducts (DBPs) may affect the lipid synthesis. However, epidemiological evidence is sparse. This study aimed investigate relationship between blood trihalomethane (THM) and risk of dyslipidemia from National Health Nutrition Examination Survey 2005–2018. We included adults (n = 16,159) whose concentrations chloroform (TCM), bromodichloromethane (BDCM), dibromochloromethane (DBCM), bromoform (TBM) were quantified. Multivariable logistic regression revealed significantly elevated risks in highest group TCM [adjusted odds ratios (ORs) 1.30, 95% confidence intervals (CIs): 1.15–1.47], BDCM (1.23,1.07–1.42), TBM (1.35, 1.08–1.68), total THMs (TTHMs; sum all four THMs) (1.30, 1.14–1.48). In subgroup analysis, these associations stronger among young/middle-aged individuals. Weighted Quantile Sum G-Computation combined THM was positively associated with risk. Our provides new a positive association dyslipidemia, underscoring need for further research confirm findings explore underlying mechanisms.

Language: Английский

Association between Blood Trihalomethane Concentrations and the Risk of Dyslipidemia: Nationally Representative Cross-Sectional Study DOI
Zihao Xu,

Xu-Lian Tang,

Hong-Xuan Huang

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 24, 2025

Experimental studies have indicated that exposure to disinfection byproducts (DBPs) may affect the lipid synthesis. However, epidemiological evidence is sparse. This study aimed investigate relationship between blood trihalomethane (THM) and risk of dyslipidemia from National Health Nutrition Examination Survey 2005–2018. We included adults (n = 16,159) whose concentrations chloroform (TCM), bromodichloromethane (BDCM), dibromochloromethane (DBCM), bromoform (TBM) were quantified. Multivariable logistic regression revealed significantly elevated risks in highest group TCM [adjusted odds ratios (ORs) 1.30, 95% confidence intervals (CIs): 1.15–1.47], BDCM (1.23,1.07–1.42), TBM (1.35, 1.08–1.68), total THMs (TTHMs; sum all four THMs) (1.30, 1.14–1.48). In subgroup analysis, these associations stronger among young/middle-aged individuals. Weighted Quantile Sum G-Computation combined THM was positively associated with risk. Our provides new a positive association dyslipidemia, underscoring need for further research confirm findings explore underlying mechanisms.

Language: Английский

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