GeroScience,
Journal Year:
2024,
Volume and Issue:
46(5), P. 4707 - 4728
Published: May 25, 2024
Aging
is
accompanied
by
an
increased
prevalence
of
degenerative
conditions,
including
those
affecting
ocular
health,
which
significantly
impact
quality
life
and
increase
the
burden
on
healthcare
systems.
Among
these,
retinal
aging
particular
concern
due
to
its
direct
link
vision
impairment,
a
leading
cause
disability
in
elderly.
Vision
loss
population
associated
with
heightened
risks
cognitive
decline,
social
isolation,
morbidity.
This
study
addresses
critical
gap
our
understanding
modifiable
lifestyle
factors,
such
as
physical
exercise,
that
may
mitigate
related
pathologies.
We
investigated
effects
different
exercise
regimens-voluntary
(recreational-type)
forced
(high-intensity)-on
health
Wistar
rats
(18-month-old),
serving
model
for
studying
translational
potential
interventions
humans.
Male
were
divided
into
four
groups:
young
control
(3-month-old)
baseline
comparison,
aged
sedentary
control,
group
engaging
voluntary
via
running
wheel
their
cage,
subjected
treadmill
six
sessions
20
min
each
per
week.
After
6-month
experimental
period,
we
assessed
function
electroretinography
(ERG),
measured
thickness
histologically,
analyzed
protein
expression
changes
relevant
oxidative
stress,
inflammation,
anti-aging
mechanisms.
Our
findings
reveal
positively
impacts
morphology,
reducing
stress
inflammation
markers
while
enhancing
expression.
In
contrast,
showed
diminished
benefits.
These
insights
underscore
importance
intensity
preference
preserving
during
aging.
The
highlights
recreational
activity
non-invasive
strategy
counteract
aging,
advocating
further
research
regimens
preventative
therapies
age-related
degenerations.
PLoS ONE,
Journal Year:
2025,
Volume and Issue:
20(4), P. e0317436 - e0317436
Published: April 18, 2025
Age-related
macular
degeneration
(AMD)
is
a
multi-factorial
degenerative
disease
of
the
retina
and
leading
cause
for
vision
loss
in
developed
world.
Air
pollution
considered
greatest
environmental
threat
to
public
health
globally.
Accumulating
evidence
indicates
that
air
may
be
modifiable
risk
factor
chronic
eye
diseases
lens
retina,
including
AMD.
We
examined
concentration
seven
particles
their
influence
on
prevalence
neovascular
AMD
Israel.
Records
patients
with
between
2016
2019
were
crossed
residential
areas
correlated
data.
rates
5
types
gas:
nitrogen
dioxide
(NO
2
),
oxide
(NO),
carbon
monoxide
(CO),
ozone
(O
3
sulphur
(SO
particulate
matter
-
PM
2.5
10
.
A
total
93
localities
across
Israel
included
analysis.
higher
greater
pollution.
NO
,
x
positively
rates,
while
O
was
negatively
rates.
However,
analysis
effect
all
pollutant
combined,
showed
complex
highly
non-linear
rate,
strongest
non-linearity
observed
monoxide.
NO2,
NOx,
PM2.5
contribute
rate
seems
have
protective
role
(probably
due
ultraviolet
filtering)
The
interaction
pollutants
should
further
studied.
Investigative Ophthalmology & Visual Science,
Journal Year:
2025,
Volume and Issue:
66(4), P. 58 - 58
Published: April 21, 2025
To
compare
the
impact
of
sodium-glucose
cotransporter
2
(SGLT2)
and
dipeptidyl
peptidase
4
(DPP-4)
inhibitors
on
age-related
macular
degeneration
(AMD)
risk
among
patients
with
type
diabetes
mellitus
(T2DM).
This
multinational,
retrospective
cohort
study
used
electronic
medical
records
from
healthcare
institutions
across
21
countries.
Adults
50
years
or
older
T2DM
who
had
a
prior
prescription
metformin
initiated
SGLT2
DPP-4
2013
to
2023
were
included.
The
inhibitor
groups
propensity
score
matched
in
1:1
ratio
balance
baseline
characteristics
followed
for
up
5
observe
occurrence
AMD.
Statistical
analysis
was
performed
using
Cox
proportional
hazards
model
Kaplan-Meier
analysis.
Our
final
included
20,966
prescribed
inhibitors.
Compared
group,
group
associated
significantly
lower
risks
AMD
(hazard
[HR],
0.71;
95%
confidence
interval
[CI],
0.58-0.85)
dry
(HR,
0.61;
CI,
0.46-0.80)
but
not
wet
0.74;
0.48-1.16).
compared
linked
reduced
White
population,
empagliflozin
dapagliflozin,
individuals
glycated
hemoglobin
<
8.5%,
estimated
glomerular
filtration
rate
≥
60
mL/min/1.73
m2,
hypertension,
dyslipidemia,
regardless
body
mass
index
level.
In
T2DM,
those
may
experience
Current Eye Research,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 7
Published: May 23, 2025
To
compare
the
computation
of
choriocapillaris
flow
deficit
obtained
from
three
different
optical
coherence
tomography
angiography
devices
in
healthy
subjects.
Twenty-six
subjects
were
included
this
post
hoc
analysis
data
a
prospective
subject
study.
Fovea-centered
6
×
volume
scans
by
all
devices:
Heidelberg
Spectralis
spectral
domain
(Heidelberg,
Germany)
using
full
spectrum
probabilistic
algorithm
(512
512
pixels);
Zeiss
Cirrus
5000
AngioPlex
(Zeiss
Meditec,
Dublin,
CA)
(spectral
domain-optical
angiography)
microangiography
(350
350
PLEX
Elite
9000
swept
source
(500
500
pixels).
Choriocapillaris
slabs
binarized
Image
J
(Bethesda,
MD)
and
%
was
measured
applying
Phansalkar
radius
∼20
µm,
adjusted
for
each
device
based
on
size
resolution
images.
eyes
26
with
no
ocular
or
systemic
disease
analysis.
The
mean
age
47.60
±
13.00
(range,
26-69)
years
46.15%
females.
varied
significantly
other
(p
<
.01).
highest
at
57.00%
(±13.21%),
followed
Angioplex
25.70%
(±9.00%),
Plex
7.62
(±3.06%).
There
significant
positive
correlation
between
source-optical
(Angioplex
Elite)
(r
=
0.78,
p
Of
note,
better
than
two
algorithms
(Spectralis,
Heidelberg,
Germany,
microangiography)
0.389,
.04).
same
is
algorithms.
GeroScience,
Journal Year:
2024,
Volume and Issue:
46(5), P. 4707 - 4728
Published: May 25, 2024
Aging
is
accompanied
by
an
increased
prevalence
of
degenerative
conditions,
including
those
affecting
ocular
health,
which
significantly
impact
quality
life
and
increase
the
burden
on
healthcare
systems.
Among
these,
retinal
aging
particular
concern
due
to
its
direct
link
vision
impairment,
a
leading
cause
disability
in
elderly.
Vision
loss
population
associated
with
heightened
risks
cognitive
decline,
social
isolation,
morbidity.
This
study
addresses
critical
gap
our
understanding
modifiable
lifestyle
factors,
such
as
physical
exercise,
that
may
mitigate
related
pathologies.
We
investigated
effects
different
exercise
regimens-voluntary
(recreational-type)
forced
(high-intensity)-on
health
Wistar
rats
(18-month-old),
serving
model
for
studying
translational
potential
interventions
humans.
Male
were
divided
into
four
groups:
young
control
(3-month-old)
baseline
comparison,
aged
sedentary
control,
group
engaging
voluntary
via
running
wheel
their
cage,
subjected
treadmill
six
sessions
20
min
each
per
week.
After
6-month
experimental
period,
we
assessed
function
electroretinography
(ERG),
measured
thickness
histologically,
analyzed
protein
expression
changes
relevant
oxidative
stress,
inflammation,
anti-aging
mechanisms.
Our
findings
reveal
positively
impacts
morphology,
reducing
stress
inflammation
markers
while
enhancing
expression.
In
contrast,
showed
diminished
benefits.
These
insights
underscore
importance
intensity
preference
preserving
during
aging.
The
highlights
recreational
activity
non-invasive
strategy
counteract
aging,
advocating
further
research
regimens
preventative
therapies
age-related
degenerations.
