‘Langya’ Virus, A Zoonotic Henipavirus Recently Emerged in China, Public Health Concerns, and Counteracting Prevention and Control Measures- An Update DOI Open Access
Ranjit Sah, Jaffer Shah, P. S. Rao

et al.

Published: Jan. 28, 2023

The risk of 'zoonotic spillovers,' or the transmission viruses from animals to humans, has been raised by climate change and devastation nature, as infectious disease experts have long warned. Even world works stop spread currently unfolding pandemic coronavirus 2019 (COVID-19) breakout monkeypox virus (MPXV), a new animal virus, Langya henipavirus (LayV), discovered in humans Eastern China. scientists say there is little danger spreading among but it shares genetic material with Hendra Nipah two other henipaviruses that infect cause life-threatening respiratory diseases. Humans infected LayV can expect experience high body temperature, cough, weariness, poor appetite, muscle discomfort, myalgia, nausea vomiting. It likely will humans. Currently, health authorities Taiwan organizations are tracking progress ailment ensure does not reach Researchers examined 25 species small wild for presence so far, shrews only ones tested positive virus's RNA. Based on these results, possible candidate natural reservoir. Too no therapies vaccines developed licensed like LayV. When fail alleviate viral infections, ribavirin may be next best thing. need novel vaccinations against infection timely delivery areas at epidemiological real. To lessen likelihood calamity being caused this newly developing crucial conduct active surveillance transparent globally collaborative manner. questions answered yet require additional study.

Language: Английский

Addressing the Nipah virus threat: A call for global vigilance and coordinated action DOI Creative Commons

Priyanka Mohapatra,

Mahalaqua Nazli Khatib, Muhammed Shabil

et al.

Clinical Infection in Practice, Journal Year: 2024, Volume and Issue: 24, P. 100390 - 100390

Published: Oct. 12, 2024

Language: Английский

Citations

2
Nipah virus: epidemiology, pathogenesis, treatment, and prevention DOI
Limei Wang, Denghui Lu, Menghao Yang

et al.

Frontiers of Medicine, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 17, 2024

Language: Английский

Citations

2
Chimeric vaccine design against the epidemic Langya Henipavirus using immunoinformatics and validation via immune simulation approaches DOI Creative Commons
Aamir Fahira,

Rana Sherdil Amin,

Uzma Arshad

et al.

Heliyon, Journal Year: 2023, Volume and Issue: 9(6), P. e17376 - e17376

Published: June 1, 2023

In July 2022, a new virus called Langya (LayV) was discovered in China patients who had fever. This is type of Henipavirus (HNV) and considered potential threat as it could spread from animals to humans. It causes respiratory disease with symptoms including fever, coughing, fatigue closely linked two other henipaviruses that are known infect humans, namely Hendra Nipah viruses. These viruses may cause fatal illnesses. Investigators believe the LayV by shrews, have infected humans directly or via an intermediary species. Thus, use vaccines immunizations against alternate strategy for prevention. this study, we employed various immunoinformatics methods predict B cell, HTL T cell epitopes proteome order find most promising candidate vaccine. The potent immunogenic non-allergenic were joined each through suitable linkers. Human β-defensin 2 adjuvant increase immunogenicity vaccine construct. final sequence multi-epitope construct modelled docking TLRs. Concisely, our results suggest docked complexes vaccine-TLRs seemed be stable. Additionally, silico cloning done using E. coli host validate expression designed GC content 54.39% CAI value 0.94 revealed component expresses efficiently host. study presents novel which will essential further experimental validations confirm safety proposed structure, eventually treat HNV-related diseases.

Language: Английский

Citations

5
Langya virus: Slope of the iceberg for unexplored pathogens DOI Creative Commons
Ruhul Amin,

Ronald Darwin,

Hitesh Chopra

et al.

International Journal of Surgery, Journal Year: 2023, Volume and Issue: 109(2), P. 163 - 164

Published: Jan. 23, 2023

Highlights Langya virus is a Henipavirus that has been found in shrews, bats, and rats. The virus's origin still unknown. Henipaviruses do not have any approved therapies. There currently no evidence the may spread from human to human. Dear Editor, rats, other small animals. Some studies also reveal animals such as dogs goats natural antibodies virus1. Furthermore, when exposed bat urine, species horses or infect pigs2. As member of RNA family Paramyxoviridae, henipavirus (LayV) evolutionary ties with Nipah Hendra virus3. Both viruses are emerging zoonotic diseases Asia-Pacific area. Despite their differences, these two antigenic, serological, ultrastructural features place them same genus4. On 4 August, it was initially reported New England Journal Medicine. Thirty-five persons China's Shandong Henan provinces contracted LayV between December 2018 May 20215. This indicates spreading among humans readily. clusters instances within family, like what happen coronavirus disease 2019, short amount time close proximity one another4,6. Contact tracing performed on nine affected persons, after contacting 15 contacts each patient, researchers infection7. finding lends credence theory transmitted person but animal To needs great deal effort direct physical contact. People fever eastern China who had just led discovery virus. In absence cure, problems be treated supportive care. Scientists investigated different for presence determine origins infection. They discovered viral dogs, shrew principal source 27% samples8. However, most likely passed Because identified mostly they its hosts9. contagiousness determined by spreadability contagiousness. facts about human-to-human transfer. scholars assert investigation's sample size too detect transmission. Conversely, close-contact transmission tracking patients relatives2. Those infected following symptoms: fever, fatigue, cough, anorexia, myalgia, nausea, headache, vomiting. 35% those contaminated impaired liver function, 8% renal function. According doctors, might cause decrease number platelets blood, significant damage kidneys liver, possibly death5. produce symptoms appetite decrease, muscle cramps, Serum seropositivity 2% 5% domestic animals10. Since identification this strain novel, serves illustrate ever-present danger creation (new) infections. Due size, further work needed fully grasp disease's epidemiological microbiological features. When comes combating potential pandemic infections, essence, making surveillance development crucial tool. experiments, experts only tested few antiviral alternatives. particular vaccination ribavirin an effective therapy. Doctors often use medicine treat infections therapeutic options. Ribavirin against viruses, including respiratory problems. Studies demonstrate both viruses. malaria chloroquine useful treating conditions1,11. result, if necessary, medications aid control unusual poorly understood, predict verified cases will rise. More study required entire scope, mode dissemination, whether already reached surrounding region. Ethical approval Not applicable. Conflicts interest disclosure conflicts interest. Sources funding No received. Author contribution R.A.: conceptualization, data curation, writing – original draft preparation, reviewing, editing. R.D. H.C.: T.B.E.: reviewing editing, visualization, supervision. Research registration unique identifying (UIN) 1. Name registry: 2. Unique ID: 3. Hyperlink your specific (must publicly accessible checked): Guarantor Talha Bin Emran, PhD, Associate Professor, Department Pharmacy, BGC Trust University Bangladesh, Chittagong 4381, Bangladesh. Tel: +880 303 356 193, fax: 312 550 224. https://orcid.org/0000-0003-3188-2272 Provenance peer review commissioned, internally peer-reviewed. Data statement correspondence article sensitive nature public domain. therefore available confidential nature.

Language: Английский

Citations

4
Corona- and Paramyxoviruses in Bats from Brazil: A Matter of Concern? DOI Creative Commons
Matheus Nunes Weber, Mariana Soares da Silva

Animals, Journal Year: 2023, Volume and Issue: 14(1), P. 88 - 88

Published: Dec. 26, 2023

Chiroptera are one of the most diverse mammal orders. They considered reservoirs main human pathogens, where coronaviruses (CoVs) and paramyxoviruses (PMVs) may be highlighted. Moreover, growing number publications on CoVs PMVs in wildlife reinforces scientific community’s interest eco-vigilance, especially because emergence important pathogens such as SARS-CoV-2 Nipha viruses. Considering that Brazil presents continental dimensions, is biologically rich containing biotas a biodiversity animals classified order Chiroptera, mapping CoV PMV genetics related to aim present work. can into four genera: Alphacoronavirus, Betacoronavirus, Deltacoronavirus Gammacoronavirus. Delta- gammacoronaviruses infect mainly birds, while alpha- betacoronaviruses contain animal pathogens. Almost 60% bats, which natural hosts these viral genera members. The studies presence bats from have assayed phyllostomid, molossid vespertilionid South, Southeast North territories. Despite not hosting rhinophilid or pteropodid SARS-related henipaviruses, respectively, reported Brazilian genetically closely some Most works performed with alpha-CoVs were other bat-CoVs, despite few reports beta-CoVs grouped Merbecovirus Embecovirus subgenera. family Paramyxoviridae includes subfamilies (Avulavirinae, Metaparamyxovirinae, Orthoparamyxovirinae Rubulavirinae), significant drivers cross-species transmission. Additionally, evaluated found sequences Jeilongvirus Morbillivirus belong subfamily. increasing amount research analyzing samples still scarce. When surveying representativeness available genomic sequences, it perceived there gaps knowledge. continuous monitoring helpful predicting future hotspots zoonotic agents.

Language: Английский

Citations

4
Infection and transmission of henipavirus in animals DOI

Xinyu Qiu,

Feng Wang, Ailong Sha

et al.

Comparative Immunology Microbiology and Infectious Diseases, Journal Year: 2024, Volume and Issue: 109, P. 102183 - 102183

Published: April 17, 2024

Language: Английский

Citations

1
Computational investigation of remdesivir, favipiravir, ribavirin, and their phosphate derivatives against Nipah virus RNA-dependent RNA polymerase DOI
Vishal S. Patil, Sanjay Deshpande,

Darasaguppe R. Harish

et al.

Molecular Simulation, Journal Year: 2024, Volume and Issue: 50(15), P. 1170 - 1182

Published: Aug. 13, 2024

Outbreaks of human Nipah virus (NiV) cases have recently been reported in several countries. With a mortality rate around 80% and no known therapy, there is an urgent need to test existing antivirals repurposed for it. Due its central role replication, the RNA-dependent RNA polymerase (RdRp) NiV-L protein potential target such antiviral therapies. In this study, Favipiravir, Remdesivir, Ribavirin, their metabolites, including monophosphate (MP), diphosphate (DP), triphosphate (TP), were virtually screened against RdRp. Using molecular dynamics (MD) simulations, lead hits from docking study examined conformational changes. Additional analyses, MM-PBSA, residual decomposition energy, principal component analysis, performed on MD trajectory. Remdesivir-TP, Favipiravir-TP, Ribavirin-TP exhibited lowest binding energies –7.8, −7.4, −6.9 kcal/mol, respectively, displayed affinity pocket 1, forming interactions with active site residues Asp726 Asn727. During 100 ns simulation, Remdesivir-TP demonstrated more stable mode compared Favipiravir-TP Ribavirin-TP. The relative −94.709 kJ/mol, −68.882 −46.98 kJ/mol Ribavirin-TP, respectively. This research anticipates be candidate drug NiV infection.

Language: Английский

Citations

1
Zoonotic Paramyxoviruses: Evolution, Ecology, and Public Health Strategies in a Changing World DOI Creative Commons
Francesco Branda, Grazia Pavia, Alessandra Ciccozzi

et al.

Viruses, Journal Year: 2024, Volume and Issue: 16(11), P. 1688 - 1688

Published: Oct. 29, 2024

The family

Language: Английский

Citations

1
Nanoparticle-Based Vaccines against Zoonotic Viruses: A Review DOI Creative Commons
Xiaowei Zhang,

Zongqiang Cui

Zoonoses, Journal Year: 2023, Volume and Issue: 3(1)

Published: Jan. 1, 2023

Vaccines are the most promising tools for maintaining public health. Most emerging human infectious diseases caused by viruses originating from an animal reservoir via zoonotic transmission. Therefore, virus spillover and spread in humans have become global health threats. Nanoparticle-based vaccines ideal antigen delivery, as adjuvants, viral structure mimics. Nanoparticles benefit vaccine design utilized to protect cargo, increase immunogenicity efficacy. nanoparticle a novel method of immunization which optimal immune responses elicited. Herein we review current approaches development highlight role against diseases.

Language: Английский

Citations

2
Cedar virus biology and its applications as a surrogate for highly pathogenic henipaviruses DOI Creative Commons

Ahmad Jawad Sabir,

Lijun Rong, Christopher C. Broder

et al.

Cell Insight, Journal Year: 2024, Volume and Issue: 3(4), P. 100181 - 100181

Published: July 2, 2024

Nipah Virus (NiV) and Hendra (HeV), are the prototype species of genus Henipavirus highly pathogenic agents capable causing fatal diseases in both animals humans. Both NiV HeV classified as biosafety level-4 (BSL-4) restricted pathogens remain only henipaviruses within known to cause systemic, severe respiratory encephalitic henipaviral disease, represent substantial transboundary threats. There no approved prophylactic or therapeutic treatments for human henipavirus infections, World Health Organization acknowledges them priority needing urgent research. The discovery Cedar virus (CedV), recognized non-pathogenic henipavirus, has provided a number unique opportunities study host interactions also facilitate countermeasure development research at lower BSL-2 containment. This review will highlight aspects CedV biology how it been exploited model developing strategies against more virulent species.

Language: Английский

Citations

0