Anti-Graying Effects of External and Internal Treatments with Luteolin on Hair in Model Mice DOI Creative Commons
Machiko Iida, Takumi Kagawa, Ichiro Yajima

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1549 - 1549

Published: Dec. 17, 2024

Little is known about the anti-graying effects of antioxidants on hair. The three (luteolin, hesperetin, and diosmetin) hair were investigated according to sequential processes graying that previously clarified in model mice [Ednrb(+/−);RET-mice]. External treatment with luteolin, but not hesperetin or diosmetin, alleviated Ednrb(+/−);RET-mice. Internal luteolin also mitigated mice. Although both treatments had very limited cycles, suppressed increase p16ink4a-positive cells bulges [senescent keratinocyte stem (KSCs)]. Both decreases expression levels endothelins KSCs their receptor (Ednrb) melanocyte (MSCs) Luteolin a special antioxidant an potency through improvement age-related dysfunction signaling between MSCs. for topical oral use commercially available people form supplements. Similar Ednrb(+/−);RET-mice humans have been reported. These results are encouraging practical application as medicine effect humans.

Language: Английский

Protective Effect of Conditioned Medium of Immortalized Human Stem Cells from Exfoliated Deciduous Teeth Against Hair Graying Caused by X-Ray Irradiation via Its Antioxidative Activity DOI Creative Commons
Yasuhiro Katahira,

Eri Horio,

Natsuki Yamaguchi

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(1), P. 109 - 109

Published: Jan. 18, 2025

Hair graying is one of the common visible signs human aging, resulting from decreased or abolished melanogenesis due to depletion melanocyte stem cells through excess accumulation oxidative stress. Cell-free therapy using a conditioned medium (CM) mesenchymal has been highlighted in field regenerative medicine owing its potent therapeutic effects with lower regulatory hurdles and safety risk. Recently, we demonstrated that CM an immortalized cell line exfoliated deciduous teeth (SHED) protective against mouse model ulcer formation via antioxidative angiogenic activities mediated by HGF VEGF. However, date, no effective treatments for hair have developed, effect SHED-CM on remains unknown. In this study, investigated caused X-ray irradiation. Repetitive subcutaneous administrations greatly suppressed development graying, when compared control medium, reduced cutaneous expression 8-hydroxy-2′-deoxyguanosine, major product DNA damage induced reactive oxygen species. Consistent these vivo results, significantly inhibited death irradiation melanoma B16F10 cells. Immunodepletion VEGF revealed inhibition was suppression generation species, which mainly probably These results suggest activity.

Language: Английский

Citations

0
Exogenous Alpha-Ketoglutaric Acid Alleviates the Rabbit Dermal Papilla Cell Oxidative Damage Caused by Hydrogen Peroxide Through the ERK/Nrf2 Signaling Pathway DOI Creative Commons
Xiaosong Wang, Shu Li, Jiali Chen

et al.

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 455 - 455

Published: April 11, 2025

As an endogenous metabolite, α-ketoglutarate (AKG) exhibits potent antioxidant properties, yet its molecular mechanisms remain unclear. Dermal Papilla Cells (DPCs), functioning as the regulatory hub of hair follicle morphogenesis, serve a pivotal model system for deciphering follicular functionality and regeneration through their orchestration signaling networks. Using hydrogen peroxide (H2O2)-induced oxidative stress in DPCs, we investigated AKG’s protective effects. AKG attenuated H2O2-triggered reactive oxygen species (ROS) overproduction, restored mitochondrial membrane potential, suppressed apoptosis-related protein dysregulation. It enhanced cellular resistance by increasing Bcl-2/Bax ratio, boosting levels, inhibiting inflammation. Mechanistically, H2O2 activated Nrf2 pathway, while amplified nuclear translocation expression. Crucially, ERK inhibition abrogated AKG-mediated regulation, intensifying ROS accumulation cell death. These results identify ERK/Nrf2 axis central to antioxidative cytoprotection. This study advances therapeutic potential deepens insights into multifunctional roles.

Language: Английский

Citations

0
Radiation-induced vascular damage and aging: a review of potential therapeutic targets and key signaling pathways DOI Creative Commons
Li Chen, Liqiu Ma

Radiation Medicine and Protection, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский

Citations

0
Intrinsic and Extrinsic Factors Associated with Hair Graying (Canities) and Therapeutic Potential of Plant Extracts and Phytochemicals DOI Creative Commons
Yong Chool Boo

Applied Sciences, Journal Year: 2024, Volume and Issue: 14(17), P. 7450 - 7450

Published: Aug. 23, 2024

This review aims to gain insight into the major causes of hair graying (canities) and how plant-derived extracts phytochemicals could alleviate this symptom. Research articles on human were searched selected using PubMed, Web Science, Google Scholar databases. We first examined intrinsic extrinsic factors associated with graying, such as reduced capacity melanin synthesis transfer, exhaustion melanocyte stem cells (MSCs) melanocytes, genetics epigenetics, race, gender, family history, aging, oxidative stress, stress hormones, systematic disorders, nutrition, smoking, alcohol consumption, lifestyle, medications, environmental factors. also various plants that have shown a potential interfere onset or progression at different levels from in vitro studies clinical studies: extract Polygonum multiflorum its components, 2,3,5,4′-tetrahydroxystilbene-2-O-β-D-glucoside emodin; Eriodictyon angustifolium flavonoid compounds, hydroxygenkwanin, sterubin, luteolin; Adzuki beans (Vigna angularis), Fuzhuan brick tea (Camellia sinensis), Gynostemma pentaphyllum; bixin, carotenoid compound found Bixa orellana; rhynchophylline, an alkaloid certain Uncaria species. Experimental evidence supports notion plant by enhancing MSC maintenance function, reducing due physiological influences, managing secretion action hormones appropriate level. It is suggested may be reversible through following tactical approaches: selective targeting p38 mitogen-activated protein kinase (MAPK)–microphthalmia-associated transcription factor (MITF) axis, nuclear erythroid 2-related 2 (NRF2), norepinephrine–β2 adrenergic receptor (β2AR)–protein A (PKA) signaling pathway.

Language: Английский

Citations

1
Factors Related to Premature Canities; A Cross-sectional Study in Lagos State, Nigeria DOI Open Access

Ezon-Ebidor Innocent Edibamode,

Edet Iboro Efiong,

Nicholas Asiwe

et al.

Asian Journal of Advanced Research and Reports, Journal Year: 2024, Volume and Issue: 18(5), P. 144 - 155

Published: March 29, 2024

Background: Canities, or graying whitening hair, is a natural part of aging caused by reduced melanin production. Premature canities occur in humans animals at young age, with factors such as genetics, lifestyle, and environmental influences contributing. The study aims to evaluate the relationship between ABO Blood type, rhesus Factor, Genotype, Lifestyle, canities. Methods: 259 respondents were involved cross-sectional descriptive design was used generate data. selected using multi-stage random sampling techniques data collection via questionnaire. Data obtained analyzed IBM SPSS version 25. Results: A participants found no significant association premature blood rhesus, genotype while lifestyle like smoking, alcohol intake showed an association. Canities various head regions, differences sexes. Smoking more common males. Depression negatively associated non-premature canities. Nutrition similar, but high carbohydrate vegetable consumption be statistically different. Conclusion: No factor, canities, (alcohol smoking) possible

Language: Английский

Citations

0
Anti-Graying Effects of External and Internal Treatments with Luteolin on Hair in Model Mice DOI Creative Commons
Machiko Iida, Takumi Kagawa, Ichiro Yajima

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(12), P. 1549 - 1549

Published: Dec. 17, 2024

Little is known about the anti-graying effects of antioxidants on hair. The three (luteolin, hesperetin, and diosmetin) hair were investigated according to sequential processes graying that previously clarified in model mice [Ednrb(+/−);RET-mice]. External treatment with luteolin, but not hesperetin or diosmetin, alleviated Ednrb(+/−);RET-mice. Internal luteolin also mitigated mice. Although both treatments had very limited cycles, suppressed increase p16ink4a-positive cells bulges [senescent keratinocyte stem (KSCs)]. Both decreases expression levels endothelins KSCs their receptor (Ednrb) melanocyte (MSCs) Luteolin a special antioxidant an potency through improvement age-related dysfunction signaling between MSCs. for topical oral use commercially available people form supplements. Similar Ednrb(+/−);RET-mice humans have been reported. These results are encouraging practical application as medicine effect humans.

Language: Английский

Citations

0