A dose–response meta-analysis of physical activity and the risk of alzheimer’s disease in prospective studies

Journal of Neurology, Journal Year: 2025, Volume and Issue: 272(4)

Published: March 7, 2025

Language: Английский

---

Associations between moderate-to-vigorous physical activity, p-tau181, and cognition in healthy older adults with memory complaints: a secondary analysis from the MAPT

The Lancet Healthy Longevity, Journal Year: 2025, Volume and Issue: 6(2), P. 100678 - 100678

Published: Feb. 1, 2025

Language: Английский

---

Physical Activity, Alzheimer Plasma Biomarkers, and Cognition

JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(3), P. e250096 - e250096

Published: March 5, 2025

Physical activity (PA) is a nonpharmacological intervention for dementia prevention. The association between PA and Alzheimer disease (AD) plasma biomarkers remains underexplored. To investigate the associations among PA; biomarkers, including β-amyloid 42/40 (Aβ42/40), phosphorylated-tau217 (ptau217), glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL); cognition. This cross-sectional study included participants with without cognitive impairment recruited from multiple memory clinics in South Korea May 2019 2022. Data were analyzed June to December 2024. was assessed as metabolic equivalent task minutes per week using International Activity Questionnaire categorized into quartiles lowest (Q1) highest (Q4). Plasma Aβ42/40, ptau217, GFAP, NfL measured. Cognition Mini-Mental State Examination (MMSE) Clinical Dementia Rating-Sum of Boxes (CDR-SB). Among 1144 (mean [SD] age 70.9 [8.7] years; 744 [65.0%] female), quartile showed significantly lower ptau217 (estimate [SE], -0.14 [0.06]; P = .01) -0.12 [0.05]; compared quartile. Higher associated higher MMSE scores [SE]: Q2, 0.93 [0.31]; .003; Q3, 0.82 [0.32]; .009; Q4, 0.94 .004) CDR-SB -0.33 [0.16]; .04; -0.37 .02; -0.55 .001) after adjusting age, sex, education years, uptake. In subgroup analyses according status, cognition more pronounced older (age ≥65 years) cognitively impaired groups younger unimpaired groups. These findings suggest that may help delay decline by modulating neurodegeneration AD-specific tau pathologies. However, design limits causal inference, longitudinal studies are needed confirm clarify these associations.

Language: Английский

---

The impact of cardiorespiratory fitness on Alzheimer's disease biomarkers and their relationships with cognitive decline.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

ABSTRACT INTRODUCTION Relationships between core Alzheimer’s disease (AD) biomarker accumulation and cognitive decline are well-established the literature generally suggests a favorable relationship of cardiorespiratory fitness (CRF) on AD cognition. Differences in risk status conversion or rates by CRF, their potential interactive relationships with remain largely unknown. METHODS Participants (N=533; MeanAGE=65, 70% female) from Wisconsin Disease Research Center Registry for Prevention underwent serial blood draws, imaging assessments (MeanFollow-up=6.0 years). PET amyloid-β (Aβ) tau (T) plasma phosphorylated tau-217 (pTau-217) were used to determine (+/-). Sex-specific estimated CRF (eCRF) tertiles created using validated equation. Kaplan-Meier survival curves Cox-proportional hazards models characterized becoming biomarker-positive. Linear mixed effects associations baseline eCRF whether modified decline. Analyses stratified +/- status. RESULTS No significant observed trajectories. However, those high group who also Aβ-(HR[95%CI]=0.42[0.20, 0.88]) pTau-217-(HR[95%CI]=0.45[0.21, 0.97]) at had significantly lower There was attenuation detrimental Aβ Aβ+/T+. DISCUSSION While did not influence trajectories, seem protect against biomarker-positive attenuate known deleterious

Language: Английский

---

Lifestyle factors and plasma biomarkers of Alzheimer's disease: A narrative review

The Journal of Prevention of Alzheimer s Disease, Journal Year: 2025, Volume and Issue: unknown, P. 100130 - 100130

Published: March 1, 2025

Alzheimer's disease (AD) is a neurodegenerative disorder characterised by amyloid-β (Aβ), tau hyperphosphorylation and neurodegeneration. Blood-based biomarkers are emerging as minimally invasive tool for detection monitoring. This review depicts the relationships between modifiable lifestyle factors (nutrition, physical activity (PA), sleep, alcohol consumption, smoking, social isolation) plasma of AD: Aβ42, Aβ40, Aβ42/40, phosphorylated tau, total neurofilament light chain (NfL) glial fibrillary acidic protein. Limited evidence suggests that better nutrition associated with favourable AD biomarker profiles PA less NfL Aβ, whilst poor sleep elevated Aβ. However, lack data inconsistent findings highlight need further investigation to substantiate or refute these trends. Moreover, future research should include analysis on according gender, metabolic health APOE status. Considering growing emphasis preventing delaying dementia onset justified.

Language: Английский

---

Blood biomarkers differentiate AD‐related versus non‐AD‐related cognitive deficits

Alzheimer s & Dementia, Journal Year: 2025, Volume and Issue: 21(3)

Published: March 1, 2025

Abstract INTRODUCTION The utility of blood‐based biomarkers for discriminating Alzheimer's disease (AD)‐related versus non‐AD‐related cognitive deficits in preclinical populations remains poorly understood. Here, we tested the capability blood markers to detect and discriminate variation performance across multiple domains a cognitively unimpaired sample. METHODS Participants ( n = 648, aged 69.9 ± 3.8, 71% female) underwent comprehensive assessment assays plasma‐based amyloid beta (Aβ)1‐42/1‐40 by mass spectrometry, phosphorylated tau (p‐tau) 181 217, p‐tau217/Aβ1‐42, glial fibrillary acidic protein (GFAP), neurofilament light (NfL). RESULTS Greater p‐tau217 was exclusively associated with poorer episodic memory (β −0.11, SE 0.04, p .003), remained so after covarying NfL. Higher NfL non‐specifically range p‐tau217. DISCUSSION Blood‐based may differentiate AD‐related deficits. This characterization will be important early intervention monitoring AD. Highlights There is heterogeneity causes decline aging. help characterize these causes. Elevated memory. cognition broad domains. Blood AD‐

Language: Английский

---

Does Physical Exercise Modify the Pathophysiology of Alzheimer’s Disease in Older Persons?

Journal of Aging Research and Lifestyle, Journal Year: 2024, Volume and Issue: 13, P. 77 - 81

Published: Jan. 1, 2024

Physical exercise is well known for its benefits on brain health. However, the mechanisms through which these occur remain discussed, especially in context of cognitive conditions such as Alzheimer's disease. The present short review summarizes findings interventional studies that examined effects training specific and non-specific biomarkers Controlled intervention published English language were selected if they assessed a physical at least 2 weeks middle-aged or older adults one following measured either brain, cerebrospinal fluid blood: beta-amyloid, tau, neurofilament light chain, glial fibrillary acidic protein. Overall, there was no strong evidence significant interventions any biomarkers. populations, women with obesity, pre-diabetes, depression, favorable changes blood beta-amyloid concentrations reported. Further also demonstrated APOE-ε4 allele carriers In conclusion, current suggests does not modulate pathophysiology disease overall population adults. Nonetheless, some metabolic disorders patients genotype, seem to be favorably affected. studies, including long follow-ups, large sample sizes, concomitantly assessing other factors sedentary behavior diet, are required bring further field.

Language: Английский

---

Understanding the Molecular Impact of Physical Exercise on Alzheimer’s Disease

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13576 - 13576

Published: Dec. 18, 2024

Alzheimer’s disease is one of the most common neurodegenerative diseases, characterized by a wide range neurological symptoms that begin with personality changes and psychiatric symptoms, progress to mild cognitive impairment, eventually lead dementia. Physical exercise part non-pharmacological treatments used in disease, as it has been shown delay process improving redox state brain tissue, providing anti-inflammatory effects or stimulating release brain-derived neurotrophic factor enhances structure performance. Here, we reviewed results obtained from studies conducted both animal models human subjects comprehend how physical interventions can exert molecular mechanisms underlying pathophysiological processes disease: amyloid β-peptide pathology, tau neuroglial changes, mitochondrial dysfunction, oxidative stress. seems have protective effect against since induce positive some biomarkers related disease. However, additional humans are necessary address current lack conclusive evidence.

Language: Английский

---

Exercise to Counteract Alzheimer’s Disease: What Do Fluid Biomarkers Say?

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(13), P. 6951 - 6951

Published: June 25, 2024

Neurodegenerative diseases (NDs) represent an unsolved problem to date with ever-increasing population incidence. Particularly, Alzheimer's disease (AD) is the most widespread ND characterized by accumulation of amyloid aggregates beta-amyloid (Aβ) and Tau proteins that lead neuronal death subsequent cognitive decline. Although neuroimaging techniques are needed diagnose AD, investigation biomarkers within body fluids could provide important information on neurodegeneration. Indeed, as there no definitive solution for monitoring these strategic importance they useful both diagnosing AD assessing progression neurodegenerative state. In this context, exercise known be effective non-pharmacological management strategy can counteract decline However, concentration fluid in patients undergoing protocols has led unclear often conflicting results, suggesting need clarify role modulating AD. Therefore, critical literature review aims gather evidence main modulatory effects efficacy usefulness counteracting neurodegeneration

Language: Английский

---

Impacto do exercício físico na prevenção de Alzheimer e doenças demenciais: uma revisão narrativa na literatura

Brazilian Journal of Health Review, Journal Year: 2024, Volume and Issue: 7(3), P. e70256 - e70256

Published: June 6, 2024

O presente artigo teve o objetivo de avaliar, por intermédio uma Revisão Narrativa literatura, impacto do exercício físico na prevenção e redução da progressão Doença Alzheimer (DA) outras demências. A DA é a demência mais prevalente no mundo, mas ainda não há fármaco capaz modificar degeneração hipocampo associado à patologia. Desta maneira, as medidas eficientes para prevenir alterar curso natural doença são farmacológicas, dentre elas atividades físicas. Em relação fisiopatologia, sabe-se que dano oxidativo relacionado níveis elevados espécies reativas oxigênio têm associação neurodegeneração pelo aumento das Proteínas Tau hiperfosforiladas, juntamente com proteína Beta Amiloide (Aβ) estão relacionadas ao Nesse ponto, exercícios físicos regulares capazes reduzir estresse Aβ e, consequência, auxiliar positivamente neurorregulação cerebral. Além fisiologia, apresentam benefícios ajudar socialização preservação autonomia, reduzindo/retardando dependência paciente. Entretanto, necessários Ensaios Clínicos Randomizados entender quais características dos melhores cada perfil paciente visando tratamento personalizado.

---