The Microbiota–Gut–Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease DOI Creative Commons
Che Mohd Nasril Che Mohd Nassir, Muhammad Danial Che Ramli, Mazira Mohamad Ghazali

et al.

Life, Journal Year: 2024, Volume and Issue: 15(1), P. 3 - 3

Published: Dec. 24, 2024

The human microbiota constitute a very complex ecosystem of microorganisms inhabiting both the inside and outside our bodies, in which health maintenance disease modification are main regulatory features. recent explosion microbiome research has begun to detail its important role neurological health, particularly concerning cerebral small vessel (CSVD), disorder associated with cognitive decline vascular dementia. This narrative review represents state-of-the-art knowledge intimate, interplay between brain through gut-brain axis (GBA) emerging glymphatic system dysfunction (glymphopathy) circulating cell-derived microparticles (MPs) as mediators these interactions. We discuss how microbial dysbiosis promotes neuroinflammation, dysfunction, impaired waste clearance brain, critical factors pathogenesis CSVD. Further, we lifestyle that shape composition functionality microbiota, focusing on sleep modifiable risk factor disorders. presents from neuroscientific perspective establish future therapeutic avenues targeting improve reduce burden

Language: Английский

Understanding perioperative risk determinants in carotid endarterectomy: the impact of compromised circle of Willis morphology on inter-hemispheric blood flow indices based on intraoperative internal carotid artery stump pulse pressure and backflow patterns DOI Creative Commons
Zsófia Czinege, Ágnes Dóra Sándor, Dániel Gyürki

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 26, 2024

Language: Английский

Citations

2
The Microbiota–Gut–Brain Axis: Key Mechanisms Driving Glymphopathy and Cerebral Small Vessel Disease DOI Creative Commons
Che Mohd Nasril Che Mohd Nassir, Muhammad Danial Che Ramli, Mazira Mohamad Ghazali

et al.

Life, Journal Year: 2024, Volume and Issue: 15(1), P. 3 - 3

Published: Dec. 24, 2024

The human microbiota constitute a very complex ecosystem of microorganisms inhabiting both the inside and outside our bodies, in which health maintenance disease modification are main regulatory features. recent explosion microbiome research has begun to detail its important role neurological health, particularly concerning cerebral small vessel (CSVD), disorder associated with cognitive decline vascular dementia. This narrative review represents state-of-the-art knowledge intimate, interplay between brain through gut-brain axis (GBA) emerging glymphatic system dysfunction (glymphopathy) circulating cell-derived microparticles (MPs) as mediators these interactions. We discuss how microbial dysbiosis promotes neuroinflammation, dysfunction, impaired waste clearance brain, critical factors pathogenesis CSVD. Further, we lifestyle that shape composition functionality microbiota, focusing on sleep modifiable risk factor disorders. presents from neuroscientific perspective establish future therapeutic avenues targeting improve reduce burden

Language: Английский

Citations

0